The Suppressor of fused gene, involved in Hedgehog signal transduction in Drosophila , is conserved in mammals

1999 ◽  
Vol 209 (5) ◽  
pp. 294-300 ◽  
Author(s):  
M. Delattre ◽  
Sandrine Briand ◽  
Mélanie Paces-Fessy ◽  
Marie-Françoise Blanchet-Tournier
Keyword(s):  
Signal Transduction ◽  
Suppressor Of Fused ◽  
Fused Gene ◽  
Hedgehog Signal Transduction ◽  
Hedgehog Signal

scholarly journals Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus

Development ◽  
2000 ◽  
Vol 127 (18) ◽  
pp. 4001-4010 ◽  
Author(s):  
N. Methot ◽  
K. Basler
Keyword(s):  
Signal Transduction ◽  
Active Form ◽  
Full Length ◽  
Nuclear Accumulation ◽  
Dependent Manner ◽  
Cubitus Interruptus ◽  
Suppressor Of Fused ◽  
Hedgehog Signal Transduction ◽  
Hedgehog Signal ◽  
Constitutively Active

Hedgehog controls the expression of key developmental genes through the conversion of the transcription factor Cubitus interruptus (Ci) into either an activator (Ci[act]) or a repressor (Ci[rep]) form. Proteolytic cleavage of full-length Ci is important for the generation of Ci[rep], but little is known about how Ci[act] arises in response to Hh. Here we examine Hh signal transduction components for their role in the conversion of full-length Ci into either Ci[act] or Ci[rep]. We report that Cos2, PKA and Fused are necessary for the generation of Ci[rep], whereas the inhibition of either Cos2 or PKA activity is a prerequisite for Ci[act] formation. Fused (Fu) kinase stimulates a constitutively active form of Ci in a Hh-dependent manner, suggesting that Fu enhances the activity rather than the formation of Ci[act]. Su(fu) reduces the nuclear accumulation of the constitutively active form of Ci, arguing that Su(fu) can function subsequent to Ci[act] formation. We propose that Hh induces target gene expression by a two-step mechanism in which Ci[act] is first formed and then accumulates in the nucleus via Fu-induced neutralization of Su(fu) activity.

Imaging of the Ciliary Cholesterol Underlying the Sonic Hedgehog Signal Transduction

2021 ◽  
pp. 49-57
Author(s):  
Tatsuo Miyamoto ◽  
Kosuke Hosoba ◽  
Silvia Natsuko Akutsu ◽  
Shinya Matsuura
Keyword(s):  
Signal Transduction ◽  
Sonic Hedgehog ◽  
Hedgehog Signal Transduction ◽  
Hedgehog Signal

scholarly journals Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

2009 ◽  
Vol 106 (9) ◽  
pp. 3196-3201 ◽  
Author(s):  
R. Rohatgi ◽  
L. Milenkovic ◽  
R. B. Corcoran ◽  
M. P. Scott
Keyword(s):  
Signal Transduction ◽  
Activation Process ◽  
Hedgehog Signal Transduction ◽  
Hedgehog Signal
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