Activity-dependent structural plasticity of Purkinje cell spines in cerebellar vermis and hemisphere

2014 ◽  
Vol 220 (5) ◽  
pp. 2895-2904 ◽  
Author(s):  
P. De Bartolo ◽  
F. Florenzano ◽  
L. Burello ◽  
F. Gelfo ◽  
L. Petrosini
Keyword(s):  
Purkinje Cell ◽  
Structural Plasticity ◽  
Cerebellar Vermis ◽  
Activity Dependent

Lesion-induced and activity-dependent structural plasticity of Purkinje cell dendritic spines in cerebellar vermis and hemisphere

2015 ◽  
Vol 221 (7) ◽  
pp. 3405-3426 ◽  
Author(s):  
Francesca Gelfo ◽  
Fulvio Florenzano ◽  
Francesca Foti ◽  
Lorena Burello ◽  
Laura Petrosini ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Dendritic Spines ◽  
Structural Plasticity ◽  
Cerebellar Vermis ◽  
Activity Dependent

scholarly journals Activity-Dependent Gating of Calcium Spikes by A-type K+ Channels Controls Climbing Fiber Signaling in Purkinje Cell Dendrites

Neuron ◽  
2014 ◽  
Vol 84 (1) ◽  
pp. 137-151 ◽  
Author(s):  
Yo Otsu ◽  
Païkan Marcaggi ◽  
Anne Feltz ◽  
Philippe Isope ◽  
Mihaly Kollo ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Climbing Fiber ◽  
Calcium Spikes ◽  
K Channels ◽  
Type K ◽  
Activity Dependent ◽  
Purkinje Cell Dendrites

scholarly journals Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Matthew CW Oswald ◽  
Paul S Brooks ◽  
Maarten F Zwart ◽  
Amrita Mukherjee ◽  
Ryan JH West ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Neuronal Plasticity ◽  
Second Messengers ◽  
Reactive Oxygen ◽  
Structural Plasticity ◽  
Oxygen Species ◽  
Redox Sensor ◽  
Motor Network ◽  
Network Output ◽  
Activity Dependent

Reactive oxygen species (ROS) have been extensively studied as damaging agents associated with ageing and neurodegenerative conditions. Their role in the nervous system under non-pathological conditions has remained poorly understood. Working with the Drosophila larval locomotor network, we show that in neurons ROS act as obligate signals required for neuronal activity-dependent structural plasticity, of both pre- and postsynaptic terminals. ROS signaling is also necessary for maintaining evoked synaptic transmission at the neuromuscular junction, and for activity-regulated homeostatic adjustment of motor network output, as measured by larval crawling behavior. We identified the highly conserved Parkinson’s disease-linked protein DJ-1β as a redox sensor in neurons where it regulates structural plasticity, in part via modulation of the PTEN-PI3Kinase pathway. This study provides a new conceptual framework of neuronal ROS as second messengers required for neuronal plasticity and for network tuning, whose dysregulation in the ageing brain and under neurodegenerative conditions may contribute to synaptic dysfunction.

scholarly journals TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory

2012 ◽  
Vol 15 (11) ◽  
pp. 1506-1515 ◽  
Author(s):  
Kwok-On Lai ◽  
Alan S L Wong ◽  
Man-Chun Cheung ◽  
Pei Xu ◽  
Zhuoyi Liang ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Structural Plasticity ◽  
Activity Dependent
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