Prenatal nicotine exposure does not cause Purkinje cell loss in the developing rat cerebellar vermis

2003 ◽  
Vol 25 (5) ◽  
pp. 633-637 ◽  
Author(s):  
Wei-Jung A. Chen ◽  
Russell B. Edwards
Keyword(s):  
Purkinje Cell ◽  
Cell Loss ◽  
Cerebellar Vermis ◽  
Nicotine Exposure ◽  
Prenatal Nicotine Exposure ◽  
Purkinje Cell Loss ◽  
Prenatal Nicotine ◽  
Developing Rat

scholarly journals Different patterns of regional Purkinje cell loss in the cerebellar vermis as a function of the timing of prenatal ethanol exposure in an ovine model

2013 ◽  
Vol 35 ◽  
pp. 7-13 ◽  
Author(s):  
Onkar B. Sawant ◽  
Emilie R. Lunde ◽  
Shannon E. Washburn ◽  
Wei-Jung A. Chen ◽  
Charles R. Goodlett ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Cell Loss ◽  
Ethanol Exposure ◽  
Cerebellar Vermis ◽  
Prenatal Ethanol Exposure ◽  
Ovine Model ◽  
Purkinje Cell Loss

scholarly journals Autistic-Like Behaviors, Oxidative Stress Status, and Histopathological Changes in Cerebellum of Valproic Acid Rat Model of Autism Are Improved by the Combined Extract of Purple Rice and Silkworm Pupae

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Nartnutda Morakotsriwan ◽  
Jintanaporn Wattanathorn ◽  
Woranan Kirisattayakul ◽  
Kowit Chaisiwamongkol
Keyword(s):  
Oxidative Stress ◽  
Valproic Acid ◽  
Purkinje Cell ◽  
Rat Model ◽  
Cell Loss ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Silkworm Pupae ◽  
Oxidative Stress Status ◽  
Purkinje Cell Loss

Due to the crucial role of oxidative stress on the pathophysiology of autism and the concept of synergistic effect, the benefit of the combined extract of purple rice and silkworm pupae (AP1) for autism disorder was the focus. Therefore, we aimed to determine the effect of AP1 on autistic-like behaviors, oxidative stress status, and histopathological change of cerebellum in valproic acid (VPA) rat model of autism. VPA was injected on postnatal day (PND) 14 and the animals were orally given AP1 at doses of 50, 100, and 200 mg·kg−1BW between PND 14 and PND 40. The autism-like behaviors were analyzed via hot-plate, rotarod, elevated plus-maze, learning, memory, and social behavior tests. Oxidative stress and the histological change in the cerebellum were assessed at the end of study. AP1 treated rats improved behaviors in all tests except that in hot-plate test. The improvement of oxidative stress and Purkinje cell loss was also observed in the cerebellum of VPA-treated rats. Our data suggest that AP1 partially reduced autism-like behaviors by improving oxidative stress and Purkinje cell loss. Further research is required to identify the active ingredients in AP1 and gender difference effect.

Reply: Purkinje cell loss in essential tremor

2014 ◽  
Vol 29 (10) ◽  
pp. 1330-1331 ◽  
Author(s):  
Holly A. Shill ◽  
Charles H. Adler ◽  
Joseph G. Hentz
Keyword(s):  
Purkinje Cell ◽  
Essential Tremor ◽  
Cell Loss ◽  
Purkinje Cell Loss
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