The frontal aslant tract underlies speech fluency in persistent developmental stuttering

2014 ◽  
Vol 221 (1) ◽  
pp. 365-381 ◽  
Author(s):  
Vered Kronfeld-Duenias ◽  
Ofer Amir ◽  
Ruth Ezrati-Vinacour ◽  
Oren Civier ◽  
Michal Ben-Shachar
Keyword(s):  
Speech Fluency ◽  
Persistent Developmental Stuttering ◽  
Frontal Aslant Tract ◽  
Developmental Stuttering

Reduced fractional anisotropy in the anterior corpus callosum is associated with reduced speech fluency in persistent developmental stuttering

2015 ◽  
Vol 143 ◽  
pp. 20-31 ◽  
Author(s):  
Oren Civier ◽  
Vered Kronfeld-Duenias ◽  
Ofer Amir ◽  
Ruth Ezrati-Vinacour ◽  
Michal Ben-Shachar
Keyword(s):  
Corpus Callosum ◽  
Fractional Anisotropy ◽  
Speech Fluency ◽  
Persistent Developmental Stuttering ◽  
Developmental Stuttering

scholarly journals Two cortical representations of voice control are differentially involved in speech fluency

2021 ◽  
Author(s):  
Nicole E Neef ◽  
Annika Primaßin ◽  
Alexander Wolff von Gudenberg ◽  
Peter Dechent ◽  
Heiner Christian Riedel ◽  
...  
Keyword(s):  
White Matter ◽  
Motor Cortex ◽  
Cortical Network ◽  
Speech Fluency ◽  
Voice Control ◽  
Persistent Developmental Stuttering ◽  
Motor Cortical ◽  
Structural Networks ◽  
Developmental Stuttering ◽  
Cortical Representations

Abstract Recent studies have identified two distinct cortical representations of voice control in humans, the ventral and the dorsal laryngeal motor cortex. Strikingly, while persistent developmental stuttering has been linked to a white matter deficit in the ventral laryngeal motor cortex, intensive fluency shaping intervention modulated the functional connectivity of the dorsal laryngeal motor cortical network. Currently, it is unknown whether the underlying structural network organization of these two laryngeal representations is distinct or differently shaped by stuttering intervention. Using probabilistic diffusion tractography in 22 individuals who stutter and participated in a fluency shaping intervention, in 18 individuals who stutter and did not participate in the intervention, and in 28 control participants, we here compare structural networks of the dorsal laryngeal motor cortex and the ventral laryngeal motor cortex and test intervention-related white matter changes. We show (i) that all participants have weaker ventral laryngeal motor cortex connections compared to the dorsal laryngeal motor cortex network, regardless of speech fluency, (ii) connections of the ventral laryngeal motor cortex were stronger in fluent speakers, (iii) the connectivity profile of the ventral laryngeal motor cortex predicted stuttering severity, (iv) but the ventral laryngeal motor cortex network is resistant to a fluency shaping intervention. Our findings substantiate a weaker structural organization of the ventral laryngeal motor cortical network in developmental stuttering and imply that assisted recovery supports neural compensation rather than normalization. Moreover, the resulting dissociation provides evidence for functionally segregated roles of the ventral laryngeal motor cortical and dorsal laryngeal motor cortical networks.

scholarly journals Two cortical representations of voice control are differentially involved in speech fluency

2020 ◽  
Author(s):  
Nicole E. Neef ◽  
Annika Primaßin ◽  
Alexander Wolff von Gudenberg ◽  
Peter Dechent ◽  
Heiner Christian Riedel ◽  
...  
Keyword(s):  
White Matter ◽  
Motor Cortex ◽  
Cortical Network ◽  
Speech Fluency ◽  
Voice Control ◽  
Persistent Developmental Stuttering ◽  
Motor Cortical ◽  
Structural Networks ◽  
Developmental Stuttering ◽  
Cortical Representations

AbstractRecent studies have identified two distinct cortical representations of voice control in humans, the ventral and the dorsal laryngeal motor cortex. Strikingly, while persistent developmental stuttering has been linked to a white matter deficit in the ventral laryngeal motor cortex, intensive fluency shaping intervention modulated the functional connectivity of the dorsal laryngeal motor cortical network. Currently, it is unknown whether the underlying structural network organization of these two laryngeal representations is distinct or differently shaped by stuttering intervention. Using probabilistic diffusion tractography in 22 individuals who stutter and participated in a fluency shaping intervention, in 18 individuals who stutter and did not participate in the intervention, and in 28 control participants, we here compare structural networks of the dorsal laryngeal motor cortex and the ventral laryngeal motor cortex and test intervention-related white matter changes. We show (i) that all participants have weaker ventral laryngeal motor cortex connections compared to the dorsal laryngeal motor cortex network, regardless of speech fluency, (ii) connections of the ventral laryngeal motor cortex were stronger in fluent speakers, (iii) the connectivity profile of the ventral laryngeal motor cortex predicted stuttering severity, (iv) but the ventral laryngeal motor cortex network is resistant to a fluency shaping intervention. Our findings substantiate a weaker structural organization of the ventral laryngeal motor cortical network in developmental stuttering and imply that assisted recovery supports neural compensation rather than normalization. Moreover, the resulting dissociation provides evidence for functionally segregated roles of the ventral laryngeal motor cortical and dorsal laryngeal motor cortical networks.

Dorsal and ventral language pathways in persistent developmental stuttering

Cortex ◽  
2016 ◽  
Vol 81 ◽  
pp. 79-92 ◽  
Author(s):  
Vered Kronfeld-Duenias ◽  
Ofer Amir ◽  
Ruth Ezrati-Vinacour ◽  
Oren Civier ◽  
Michal Ben-Shachar
Keyword(s):  
Persistent Developmental Stuttering ◽  
Developmental Stuttering ◽  
Language Pathways

Predicting Persistent Developmental Stuttering Using a Cumulative Risk Approach

2021 ◽  
pp. 1-26
Author(s):  
Cara M. Singer ◽  
Sango Otieno ◽  
Soo-Eun Chang ◽  
Robin M. Jones
Keyword(s):  
Risk Factors ◽  
Predictive Validity ◽  
Predictive Factors ◽  
Language Skills ◽  
Speech Sound ◽  
Cumulative Risk ◽  
Standard Score ◽  
Persistent Developmental Stuttering ◽  
Risk Approach ◽  
Developmental Stuttering

Purpose: The purpose of this study was to explore how well a cumulative risk approach, based on empirically supported predictive factors, predicts whether a young child who stutters is likely to develop persistent developmental stuttering. In a cumulative risk approach, the number of predictive factors indicating a child is at risk to develop persistent stuttering is evaluated, and a greater number of indicators of risk are hypothesized to confer greater risk of persistent stuttering. Method: We combined extant data on 3- to 5-year-old children who stutter from two longitudinal studies to identify cutoff values for continuous predictive factors (e.g., speech and language skills, age at onset, time since onset, stuttering frequency) and, in combination with binary predictors (e.g., sex, family history of stuttering), used all-subsets regression and receiver operating characteristic curves to compare the predictive validity of different combinations of 10 risk factors. The optimal combination of predictive factors and the odds of a child developing persistent stuttering based on an increasing number of factors were calculated. Results: Based on 67 children who stutter (i.e., 44 persisting and 23 recovered) with relatively strong speech-language skills, the predictive factor model that yielded the best predictive validity was based on time since onset (≥ 19 months), speech sound skills (≤ 115 standard score), expressive language skills (≤ 106 standard score), and stuttering severity (≥ 17 Stuttering Severity Instrument total score). When the presence of at least two predictive factors was used to confer elevated risk to develop persistent stuttering, the model yielded 93% sensitivity and 65% specificity. As a child presented with a greater number of these four risk factors, the odds for persistent stuttering increased. Conclusions: Findings support the use of a cumulative risk approach and the predictive utility of assessing multiple domains when evaluating a child's risk of developing persistent stuttering. Clinical implications and future directions are discussed.

An Advanced Concept of Altered Auditory Feedback as a Prosthesis-Therapy for Stuttering Founded on a Non-Speech Etiologic Paradigm

2011 ◽  
pp. 1284-1326
Author(s):  
Manuel Prado-Velasco ◽  
Carlos Fernández-Peruchena
Keyword(s):  
Auditory Feedback ◽  
Intelligent System ◽  
Adult Population ◽  
True Nature ◽  
New Approach ◽  
Persistent Developmental Stuttering ◽  
The World ◽  
Developmental Stuttering ◽  
Neuroimaging Techniques

Persistent Developmental Stuttering affects 1-2% of the world adult population. Its etiology is still unknown, although modern neuroimaging techniques have shown a new and exciting perspective of earlier ideas and hypotheses. However, it is now clear that a new approach to understand the true nature of the disorder is needed. We present a new etiological model of persistent developmental stuttering based on a deep analysis of earlier models and on the stuttering phenomenology, described in basic, clinical, and even ethnographic sources. One of the more stimulating conclusions has been the suggestion that stuttering is a non-speech based disorder, in opposition to the accepted belief. The implications of this model have guided the design of a new adaptive AAF device for prosthetic and therapeutic functions. It is supported by a wearable multimodal intelligent system, which evolves from a preliminary proposal presented in (Prado & Roa, 2007).

Exploratory Randomized Clinical Study of Pagoclone in Persistent Developmental Stuttering

2010 ◽  
Vol 30 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Gerald Maguire ◽  
David Franklin ◽  
Nick G. Vatakis ◽  
Elena Morgenshtern ◽  
Timothey Denko ◽  
...  
Keyword(s):  
Clinical Study ◽  
Randomized Clinical Study ◽  
Persistent Developmental Stuttering ◽  
Developmental Stuttering

scholarly journals A study of the role of the FOXP2 and CNTNAP2 genes in persistent developmental stuttering

2014 ◽  
Vol 69 ◽  
pp. 23-31 ◽  
Author(s):  
Tae-Un Han ◽  
John Park ◽  
Carlos F. Domingues ◽  
Danilo Moretti-Ferreira ◽  
Emily Paris ◽  
...  
Keyword(s):  
Persistent Developmental Stuttering ◽  
Developmental Stuttering

scholarly journals Speech preparation in adults with persistent developmental stuttering

2015 ◽  
Vol 149 ◽  
pp. 97-105 ◽  
Author(s):  
Jeffrey R. Mock ◽  
Anne L. Foundas ◽  
Edward J. Golob
Keyword(s):  
Persistent Developmental Stuttering ◽  
Developmental Stuttering

Similar within-utterance loci of dysfluency in acquired neurogenic and persistent developmental stuttering

2019 ◽  
Vol 189 ◽  
pp. 1-9
Author(s):  
Ludo Max ◽  
Mahrukh Kadri ◽  
Takashi Mitsuya ◽  
Venu Balasubramanian
Keyword(s):  
Persistent Developmental Stuttering ◽  
Developmental Stuttering
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