Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil

2017 ◽  
Vol 116 (5) ◽  
pp. 1423-1431 ◽  
Author(s):  
Cláudia Maria Castro Gomes ◽  
Maria Gloria Teixeira Sousa ◽  
Joyce Prieto Bezerra Menezes ◽  
Marliane Campos Batista ◽  
Ana Carolina Stocco Lima ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Amazonian Brazil ◽  
Human Cutaneous Leishmaniasis

scholarly journals Characterization of Neutrophil Function in Human Cutaneous Leishmaniasis Caused by Leishmania braziliensis

2016 ◽  
Vol 10 (5) ◽  
pp. e0004715 ◽  
Author(s):  
Jacilara Conceição ◽  
Richard Davis ◽  
Pedro Paulo Carneiro ◽  
Angela Giudice ◽  
Aline C. Muniz ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Neutrophil Function ◽  
Leishmania Braziliensis ◽  
Human Cutaneous Leishmaniasis

Characterization of Leishmania sp. strains isolated from autochthonous cases of human cutaneous leishmaniasis in Santa Catarina State, southern Brazil

Acta Tropica ◽  
2000 ◽  
Vol 74 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Edmundo C Grisard ◽  
Mário Steindel ◽  
Jeffrey J Shaw ◽  
Edna A.Y Ishikawa ◽  
Carlos J Carvalho-Pinto ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Southern Brazil ◽  
Santa Catarina ◽  
Human Cutaneous Leishmaniasis ◽  
Santa Catarina State

The expression of TLR9 in human cutaneous leishmaniasis is associated with granuloma

2010 ◽  
Vol 32 (11-12) ◽  
pp. 769-772 ◽  
Author(s):  
F. F. TUON ◽  
E. R. FERNANDES ◽  
C. PAGLIARI ◽  
M. I. S. DUARTE ◽  
V. S. AMATO
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Human Cutaneous Leishmaniasis

scholarly journals First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex

2015 ◽  
Vol 45 (11) ◽  
pp. 679-684 ◽  
Author(s):  
Godwin Kwakye-Nuako ◽  
Mba-Tihssommah Mosore ◽  
Christopher Duplessis ◽  
Michelle D. Bates ◽  
Naiki Puplampu ◽  
...  
Keyword(s):  
New Species ◽  
Cutaneous Leishmaniasis ◽  
Leishmania Enriettii ◽  
Human Cutaneous Leishmaniasis ◽  
A New Species

scholarly journals Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Lucio Roberto Castellano ◽  
Laurent Argiro ◽  
Helia Dessein ◽  
Alain Dessein ◽  
Marcos Vinícius da Silva ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Therapeutic Strategy ◽  
Interleukin 10 ◽  
Leishmania Braziliensis ◽  
Soluble Antigen ◽  
Innovative Strategies ◽  
Host Protection ◽  
Human Cutaneous Leishmaniasis ◽  
Potential Use ◽  
Worse Prognosis

Interleukin-10 overproduction has been associated with worse prognosis in human cutaneous leishmaniasis, while IFN-γ-dependent responses are associated with parasite killing and host protection. Innovative strategies are needed to overcome therapeutic failure observed in endemic areas. The use of monoclonal antibody-based immunotherapy targeting IL-10 cytokine was evaluated here. Partial IL-10 blockade inLeishmania braziliensiswhole soluble antigen-stimulated cells from endemic area CL patients with active or healed lesions and asymptomatic controls was evaluated. Overall decrease in IL-10, IL-4, and TNF-αproduction was observed in all groups of subjects. Only patients with active lesions still produced some levels of TNF-αafter anti-IL-10 stimulation in association withLeishmaniaantigens. Moreover, this strategy showed limited modulatory effects on IFN-γ-dependent chemokine CXCL10 production. Results suggest the potential immunotherapeutic use of partial IL-10 blockade in localized cutaneous leishmaniasis.

scholarly journals Molecular Characterization of Leishmania RNA virus 2 in Leishmania major from Uzbekistan

Genes ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 830 ◽  
Author(s):  
Yuliya Kleschenko ◽  
Danyil Grybchuk ◽  
Nadezhda S. Matveeva ◽  
Diego H. Macedo ◽  
Evgeny N. Ponirovsky ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Cutaneous Leishmaniasis ◽  
Molecular Characterization ◽  
Leishmania Major ◽  
Geographical Origin ◽  
Rna Virus ◽  
Viral Sequences

Here we report sequence and phylogenetic analysis of two new isolates of Leishmania RNA virus 2 (LRV2) found in Leishmania major isolated from human patients with cutaneous leishmaniasis in south Uzbekistan. These new virus-infected flagellates were isolated in the same region of Uzbekistan and the viral sequences differed by only nineteen SNPs, all except one being silent mutations. Therefore, we concluded that they belong to a single LRV2 species. New viruses are closely related to the LRV2-Lmj-ASKH documented in Turkmenistan in 1995, which is congruent with their shared host (L. major) and common geographical origin.

Characterization of serum cytokines and circulating microRNAs that are predicted to regulate inflammasome genes in cutaneous leishmaniasis patients

2020 ◽  
Vol 210 ◽  
pp. 107846
Author(s):  
Lucilla Silva Oliveira Mendonça ◽  
Jaqueline Marques Santos ◽  
Carla Martins Kaneto ◽  
Luciana Debortoli de Carvalho ◽  
Jane Lima-Santos ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Circulating Micrornas ◽  
Serum Cytokines

scholarly journals In situ expression of interleukin-10 and interleukin-12 in active human cutaneous leishmaniasis

1996 ◽  
Vol 15 (2-3) ◽  
pp. 101-107 ◽  
Author(s):  
Peter C. Melby ◽  
Fernando Andrade-Narvaez ◽  
Barbara J. Darnell ◽  
Guillermo Valencia-Pacheco
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Interleukin 10 ◽  
Interleukin 12 ◽  
Human Cutaneous Leishmaniasis
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