The antidepressant clomipramine induces programmed cell death in Leishmania amazonensis through a mitochondrial pathway

2019 ◽  
Vol 118 (3) ◽  
pp. 977-989 ◽  
Author(s):  
Jean Henrique da Silva Rodrigues ◽  
Nathielle Miranda ◽  
Hélito Volpato ◽  
Tânia Ueda-Nakamura ◽  
Celso Vataru Nakamura
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Mitochondrial Pathway ◽  
Leishmania Amazonensis

scholarly journals Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes

2011 ◽  
Vol 106 (4) ◽  
pp. 507-509 ◽  
Author(s):  
Fernanda de Aquino Marinho ◽  
Keyla Cristiny da Silva Gonçalves ◽  
Selma Soares de Oliveira ◽  
Ana-Carolina de Siqueira Couto de Oliveira ◽  
Maria Bellio ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Leishmania Amazonensis

Plant mitochondrial pathway leading to programmed cell death

2007 ◽  
Vol 129 (1) ◽  
pp. 242-252 ◽  
Author(s):  
Angelo Vianello ◽  
Marco Zancani ◽  
Carlo Peresson ◽  
Elisa Petrussa ◽  
Valentino Casolo ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Mitochondrial Pathway

scholarly journals The Program Cell Death (Apoptosis) and the Therapy of Cancer

2021 ◽  
Author(s):  
Hilal Kalkan
Keyword(s):  
Drug Resistance ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Mitochondrial Pathway ◽  
Type I ◽  
Incurable Cancer ◽  
Cell Death Pathway ◽  
Anti Cancer ◽  
Apoptotic Proteins ◽  
Cell Death Mechanisms

Apoptosis plays many vital roles in maintaining organ homeostasis and represents type I programmed cell death. Programmed cell death happens when the DNA damage is irremediable and has two important pathways, the intrinsic death pathway also known as the mitochondrial pathway, and the extrinsic programmed cell death pathway. Any defects in the regulation of these crucial pathways have been associated with many disorders, most importantly cancer. Therefore, understanding the molecular basis of apoptosis is essential for the treatment of incurable cancer. To date, several anti-cancer drugs have been developed by targeting anti-apoptotic proteins, which are upregulated in many cancers. Nonetheless, a disease progression often time warranted due to the deregulation of several anti or pro-apoptotic proteins which also contribute to drug resistance. Hence, it is important to understand the maintenance and counteraction of apoptosis and improve successful new pharmacological applications of cell death mechanisms for future therapies. This chapter discusses the mechanism of apoptosis and emerging principles of drug resistance in cancer.

Differential insult-dependent recruitment of the intrinsic mitochondrial pathway during neuronal programmed cell death

2008 ◽  
Vol 66 (1) ◽  
pp. 156-172 ◽  
Author(s):  
S. Diwakarla ◽  
P. Nagley ◽  
M. L. R. Hughes ◽  
B. Chen ◽  
P. M. Beart
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Mitochondrial Pathway
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