scholarly journals Zinc induces caspase-dependent mitochondrial pathway of the programmed cell death in haemocytes of Drosophila melanogaster

BioMetals ◽  
2012 ◽  
Vol 25 (3) ◽  
pp. 507-516 ◽  
Author(s):  
Marta Filipiak ◽  
Grzegorz Tylko ◽  
Elzbieta Pyza
Keyword(s):  
Cell Death ◽  
Drosophila Melanogaster ◽  
Programmed Cell Death ◽  
Mitochondrial Pathway

Plant mitochondrial pathway leading to programmed cell death

2007 ◽  
Vol 129 (1) ◽  
pp. 242-252 ◽  
Author(s):  
Angelo Vianello ◽  
Marco Zancani ◽  
Carlo Peresson ◽  
Elisa Petrussa ◽  
Valentino Casolo ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Mitochondrial Pathway

scholarly journals Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila

2002 ◽  
Vol 9 (2) ◽  
pp. 59-69 ◽  
Author(s):  
S. Gorski ◽  
M. Marra
Keyword(s):  
Cell Death ◽  
Drosophila Melanogaster ◽  
Programmed Cell Death ◽  
Gene Discovery ◽  
Fruit Fly ◽  
Model System ◽  
Physiological Process ◽  
Wide Spread ◽  
Cell Death Gene ◽  
Genetics And Genomics

Programmed cell death (PCD) is an essential and wide-spread physiological process that results in the elimination of cells. Genes required to carry out this process have been identified, and many of these remain the subjects of intense investigation. Here, we describe PCD, its functions, and some of the consequences when it goes awry. We review PCD in the model system, the fruit fly, Drosophila melanogaster, with a particular emphasis on cell death gene discovery resulting from both genetics and genomics-based approaches.

The antidepressant clomipramine induces programmed cell death in Leishmania amazonensis through a mitochondrial pathway

2019 ◽  
Vol 118 (3) ◽  
pp. 977-989 ◽  
Author(s):  
Jean Henrique da Silva Rodrigues ◽  
Nathielle Miranda ◽  
Hélito Volpato ◽  
Tânia Ueda-Nakamura ◽  
Celso Vataru Nakamura
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Mitochondrial Pathway ◽  
Leishmania Amazonensis

scholarly journals The Reaper-Binding Protein Scythe Modulates Apoptosis and Proliferation during Mammalian Development

2005 ◽  
Vol 25 (23) ◽  
pp. 10329-10337 ◽  
Author(s):  
Fabienne Desmots ◽  
Helen R. Russell ◽  
Youngsoo Lee ◽  
Kelli Boyd ◽  
Peter J. McKinnon
Keyword(s):  
Cell Death ◽  
Drosophila Melanogaster ◽  
Programmed Cell Death ◽  
Xenopus Laevis ◽  
Cellular Proliferation ◽  
Nuclear Protein ◽  
Normal Development ◽  
Mammalian Development ◽  
Developmental Defects ◽  
Cell Extracts

ABSTRACT Scythe (BAT3 [HLA-B-associated transcript 3]) is a nuclear protein that has been implicated in apoptosis, as it can modulate Reaper, a central apoptotic regulator in Drosophila melanogaster. While Scythe can markedly affect Reaper-dependent apoptosis in Xenopus laevis cell extracts, the function of Scythe in mammals is unknown. Here, we report that inactivation of Scythe in the mouse results in lethality associated with pronounced developmental defects in the lung, kidney, and brain. In all cases, these developmental defects were associated with dysregulation of apoptosis and cellular proliferation. Scythe − / − cells were also more resistant to apoptosis induced by menadione and thapsigargin. These data show that Scythe is critical for viability and normal development, probably via regulation of programmed cell death and cellular proliferation.

scholarly journals The head involution defective gene of Drosophila melanogaster functions in programmed cell death.

1995 ◽  
Vol 9 (14) ◽  
pp. 1694-1708 ◽  
Author(s):  
M E Grether ◽  
J M Abrams ◽  
J Agapite ◽  
K White ◽  
H Steller
Keyword(s):  
Cell Death ◽  
Drosophila Melanogaster ◽  
Programmed Cell Death ◽  
Defective Gene
Sign in / Sign up

Export Citation Format

Share Document