A systematic analysis of disease-associated variants in the 3′ regulatory regions of human protein-coding genes I: general principles and overview

2006 ◽  
Vol 120 (1) ◽  
pp. 1-21 ◽  
Author(s):  
Jian-Min Chen ◽  
Claude Férec ◽  
David N. Cooper
Keyword(s):  
Human Protein ◽  
Regulatory Regions ◽  
Systematic Analysis ◽  
Protein Coding ◽  
Protein Coding Genes

Biogenic mechanisms and utilization of small RNAs derived from human protein-coding genes

2011 ◽  
Vol 18 (9) ◽  
pp. 1075-1082 ◽  
Author(s):  
Eivind Valen ◽  
Pascal Preker ◽  
Peter Refsing Andersen ◽  
Xiaobei Zhao ◽  
Yun Chen ◽  
...  
Keyword(s):  
Small Rnas ◽  
Human Protein ◽  
Protein Coding ◽  
Protein Coding Genes

scholarly journals A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes

2019 ◽  
Vol 34 (1-2) ◽  
pp. 132-145 ◽  
Author(s):  
Joshua D. Eaton ◽  
Laura Francis ◽  
Lee Davidson ◽  
Steven West
Keyword(s):  
Human Protein ◽  
Protein Coding ◽  
Protein Coding Genes ◽  
Transcriptional Termination

scholarly journals Overlapping protein-coding genes in human genome and their coincidental expression in tissues

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chao-Hsin Chen ◽  
Chao-Yu Pan ◽  
Wen-chang Lin
Keyword(s):  
Human Genome ◽  
Expression Profiles ◽  
Tissue Expression ◽  
Human Protein ◽  
Clear Understanding ◽  
Overlapping Genes ◽  
Genome Sequences ◽  
Protein Coding ◽  
Protein Coding Genes ◽  
Overlapping Gene

Abstract The completion of human genome sequences and the advancement of next-generation sequencing technologies have engendered a clear understanding of all human genes. Overlapping genes are usually observed in compact genomes, such as those of bacteria and viruses. Notably, overlapping protein-coding genes do exist in human genome sequences. Accordingly, we used the current Ensembl gene annotations to identify overlapping human protein-coding genes. We analysed 19,200 well-annotated protein-coding genes and determined that 4,951 protein-coding genes overlapped with their adjacent genes. Approximately a quarter of all human protein-coding genes were overlapping genes. We observed different clusters of overlapping protein-coding genes, ranging from two genes (paired overlapping genes) to 22 genes. We also divided the paired overlapping protein-coding gene groups into four subtypes. We found that the divergent overlapping gene subtype had a stronger expression association than did the subtypes of 5ʹ-tandem overlapping and 3ʹ-tandem overlapping genes. The majority of paired overlapping genes exhibited comparable coincidental tissue expression profiles; however, a few overlapping gene pairs displayed distinctive tissue expression association patterns. In summary, we have carefully examined the genomic features and distributions about human overlapping protein-coding genes and found coincidental expression in tissues for most overlapping protein-coding genes.

Systematic Analysis of Missing Proteins Provides Clues to Help Define All of the Protein-Coding Genes on Human Chromosome 1

2013 ◽  
Vol 13 (1) ◽  
pp. 114-125 ◽  
Author(s):  
Chengpu Zhang ◽  
Ning Li ◽  
Linhui Zhai ◽  
Shaohang Xu ◽  
Xiaohui Liu ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Chromosome 1 ◽  
Systematic Analysis ◽  
Protein Coding ◽  
Protein Coding Genes ◽  
Human Chromosome 1
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