Real-time analyte monitoring of a fungal fermentation, at pilot scale, using in situ mid-infrared spectroscopy

2001 ◽  
Vol 24 (1) ◽  
pp. 13-24 ◽  
Author(s):  
Pollard D. ◽  
Buccino R. ◽  
Connors N. ◽  
Kirschner T. ◽  
Olewinski R. ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Real Time ◽  
Pilot Scale ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy ◽  
Fungal Fermentation

A method for real time detection of reaction endpoints using a moving window t-test of in situ time course data

2020 ◽  
Vol 5 (9) ◽  
pp. 1642-1646
Author(s):  
Elyse N. T. DiMaso ◽  
Robert W. Bondi ◽  
John Guo ◽  
Alexander G. O'Brien
Keyword(s):  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Real Time ◽  
Time Course ◽  
Test Method ◽  
Moving Window ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy ◽  
Time Course Data

In-line Fourier transform mid-infrared spectroscopy (FTIR) in combination with a moving window t-test method was used to determine the endpoint of a reaction with a highly inconsistent rate.

Real-time isotopic methane detection using mid-infrared spectroscopy

2020 ◽  
Vol 59 (34) ◽  
pp. 10801
Author(s):  
Jinghao Yang ◽  
Junchao Zhou ◽  
Pao Tai Lin
Keyword(s):  
Infrared Spectroscopy ◽  
Real Time ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy ◽  
Methane Detection

Application of Mid-Infrared Spectroscopy to the Development and Transfer of a Manufacturing Process for an Active Pharmaceutical Ingredient

2012 ◽  
Vol 66 (5) ◽  
pp. 574-579 ◽  
Author(s):  
Ian M. Clegg ◽  
Adrian M. Daly ◽  
Craig Donnelly ◽  
Ruth Hardy ◽  
Denise Harris ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Chemical Transformation ◽  
Manufacturing Process ◽  
Active Pharmaceutical Ingredient ◽  
Pharmaceutical Manufacturing ◽  
Process Data ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy ◽  
Whole Process

The use of in situ mid-infrared spectroscopy to support the development of a pharmaceutical manufacturing process is disclosed. Data on this two-stage telescoped reaction from several reaction scales (<50 mL to 1600 liters) and at multiple manufacturing locations is shown. In addition to providing data on both reactions in the telescope, the mid-IR data has been used to monitor an intermediate distillation operation and therefore it has been possible to profile the whole process. Data is also shown on aliquot addition during the first chemical transformation, which is used to check the instrumentation.

Mid‐infrared spectroscopy as a tool for real‐time monitoring of ethanol absorption in glycols

2020 ◽  
Vol 99 (1) ◽  
pp. 401-409
Author(s):  
Kaio C. S. Rodrigues ◽  
Ivan I. K. Veloso ◽  
Marcelo P. A. Ribeiro ◽  
Antonio J. G. Cruz ◽  
Alberto C. Badino
Keyword(s):  
Infrared Spectroscopy ◽  
Real Time ◽  
Real Time Monitoring ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy

Real-time monitoring of nitrile biotransformations by mid-infrared spectroscopy

2000 ◽  
Vol 41 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Michael R. Dadd ◽  
David C.A. Sharp ◽  
Alan J. Pettman ◽  
Christopher J. Knowles
Keyword(s):  
Infrared Spectroscopy ◽  
Real Time ◽  
Real Time Monitoring ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy

In Situ Mid-Infrared Spectroscopy for Process Development

2007 ◽  
pp. 313-316
Author(s):  
David Conlon ◽  
J Christopher McWilliams ◽  
Robert Reamer ◽  
Bill Izzo ◽  
Paul Collins ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Process Development ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy

Potential and limitation of mid-infrared attenuated total reflectance spectroscopy for real time analysis of raw milk in milking lines

2008 ◽  
Vol 76 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Raphael Linker ◽  
Yael Etzion
Keyword(s):  
Infrared Spectroscopy ◽  
Real Time ◽  
Reflectance Spectroscopy ◽  
Attenuated Total Reflectance ◽  
Time Analysis ◽  
Mid Infrared ◽  
Total Reflectance ◽  
Mid Infrared Spectroscopy ◽  
Real Time Analysis ◽  
Line Analysis

Real-time information about milk composition would be very useful for managing the milking process. Mid-infrared spectroscopy, which relies on fundamental modes of molecular vibrations, is routinely used for off-line analysis of milk and the purpose of the present study was to investigate the potential of attenuated total reflectance mid-infrared spectroscopy for real-time analysis of milk in milking lines. The study was conducted with 189 samples from over 70 cows that were collected during an 18 months period. Principal component analysis, wavelets and neural networks were used to develop various models for predicting protein and fat concentration. Although reasonable protein models were obtained for some seasonal sub-datasets (determination errors <~0·15% protein), the models lacked robustness and it was not possible to develop a model suitable for all the data. Determination of fat concentration proved even more problematic and the determination errors remained unacceptably large regardless of the sub-dataset analyzed or of the spectral intervals used. These poor results can be explained by the limited penetration depth of the mid-infrared radiation that causes the spectra to be very sensitive to the presence of fat globules or fat biofilms in the boundary layer that forms at the interface between the milk and the crystal that serves both as radiation waveguide and sensing element. Since manipulations such as homogenisation are not permissible for in-line analysis, these results show that the potential of mid-infrared attenuated total reflectance spectroscopy for in-line milk analysis is indeed quite limited.

Temperature Influence in Real-Time Monitoring of Fed-Batch Ethanol Fermentation by Mid-Infrared Spectroscopy

2020 ◽  
Vol 59 (41) ◽  
pp. 18425-18433
Author(s):  
Ivan I. K. Veloso ◽  
Kaio C. S. Rodrigues ◽  
Marcelo P. A. Ribeiro ◽  
Antonio J. G. Cruz ◽  
Alberto C. Badino
Keyword(s):  
Infrared Spectroscopy ◽  
Real Time ◽  
Ethanol Fermentation ◽  
Temperature Influence ◽  
Real Time Monitoring ◽  
Fed Batch ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy
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