In Situ Mid-Infrared Spectroscopy for Process Development

2007 ◽  
pp. 313-316
Author(s):  
David Conlon ◽  
J Christopher McWilliams ◽  
Robert Reamer ◽  
Bill Izzo ◽  
Paul Collins ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Process Development ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy

A method for real time detection of reaction endpoints using a moving window t-test of in situ time course data

2020 ◽  
Vol 5 (9) ◽  
pp. 1642-1646
Author(s):  
Elyse N. T. DiMaso ◽  
Robert W. Bondi ◽  
John Guo ◽  
Alexander G. O'Brien
Keyword(s):  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Real Time ◽  
Time Course ◽  
Test Method ◽  
Moving Window ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy ◽  
Time Course Data

In-line Fourier transform mid-infrared spectroscopy (FTIR) in combination with a moving window t-test method was used to determine the endpoint of a reaction with a highly inconsistent rate.

Application of Mid-Infrared Spectroscopy to the Development and Transfer of a Manufacturing Process for an Active Pharmaceutical Ingredient

2012 ◽  
Vol 66 (5) ◽  
pp. 574-579 ◽  
Author(s):  
Ian M. Clegg ◽  
Adrian M. Daly ◽  
Craig Donnelly ◽  
Ruth Hardy ◽  
Denise Harris ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Chemical Transformation ◽  
Manufacturing Process ◽  
Active Pharmaceutical Ingredient ◽  
Pharmaceutical Manufacturing ◽  
Process Data ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy ◽  
Whole Process

The use of in situ mid-infrared spectroscopy to support the development of a pharmaceutical manufacturing process is disclosed. Data on this two-stage telescoped reaction from several reaction scales (<50 mL to 1600 liters) and at multiple manufacturing locations is shown. In addition to providing data on both reactions in the telescope, the mid-IR data has been used to monitor an intermediate distillation operation and therefore it has been possible to profile the whole process. Data is also shown on aliquot addition during the first chemical transformation, which is used to check the instrumentation.

Real-time analyte monitoring of a fungal fermentation, at pilot scale, using in situ mid-infrared spectroscopy

2001 ◽  
Vol 24 (1) ◽  
pp. 13-24 ◽  
Author(s):  
Pollard D. ◽  
Buccino R. ◽  
Connors N. ◽  
Kirschner T. ◽  
Olewinski R. ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Real Time ◽  
Pilot Scale ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy ◽  
Fungal Fermentation

Determination of main raw material source in bar soaps using mid-infrared spectroscopy combined with classification tools

2021 ◽  
Vol 164 ◽  
pp. 106029
Author(s):  
Diego Maciel Gerônimo ◽  
Sheila Catarina de Oliveira ◽  
Frederico Luis Felipe Soares ◽  
Patricio Peralta-Zamora ◽  
Noemi Nagata
Keyword(s):  
Infrared Spectroscopy ◽  
Raw Material ◽  
Material Source ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy
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