Comparison of high-frequency intensive balneotherapy with low-frequency balneotherapy combined with land-based exercise on postural control in symptomatic knee osteoarthritis: a randomized clinical trial

2019 ◽  
Vol 63 (9) ◽  
pp. 1151-1159 ◽  
Author(s):  
Laetitia Peultier-Celli ◽  
Alexis Lion ◽  
Isabelle Chary-Valckenaere ◽  
Damien Loeuille ◽  
Zheng Zhang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Postural Control ◽  
Knee Osteoarthritis ◽  
Randomized Clinical Trial ◽  
High Frequency ◽  
Low Frequency ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

scholarly journals Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial

2019 ◽  
Vol 8 (2) ◽  
pp. 265 ◽  
Author(s):  
Sara Harper ◽  
Lisa Roberts ◽  
Andrew Layne ◽  
Byron Jaeger ◽  
Anna Gardner ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Blood Flow ◽  
Resistance Training ◽  
Knee Osteoarthritis ◽  
Randomized Clinical Trial ◽  
Blood Flow Restriction ◽  
Moderate Intensity ◽  
Flow Restriction ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

In a pilot randomized clinical trial, participants aged ≥60 years (n = 35) with physical limitations and symptomatic knee osteoarthritis (OA) were randomized to 12 weeks of lower-body low-load resistance training with blood-flow restriction (BFR) or moderate-intensity resistance training (MIRT) to evaluate changes in muscle strength, pain, and physical function. Four exercises were performed three times per week to volitional fatigue using 20% and 60% of one repetition maximum (1RM). Study outcomes included knee extensor strength, gait speed, Short Physical Performance Battery (SPPB) performance, and pain via the Western Ontario and McMaster Universities OA Index (WOMAC). Per established guidance for pilot studies, primary analyses for the trial focused on safety, feasibility, and effect sizes/95% confidence intervals of dependent outcomes to inform a fully-powered trial. Across three speeds of movement, the pre- to post-training change in maximal isokinetic peak torque was 9.96 (5.76, 14.16) Nm while the mean difference between groups (BFR relative to MIRT) was −1.87 (−10.96, 7.23) Nm. Most other directionally favored MIRT, though more spontaneous reports of knee pain were observed (n = 14) compared to BFR (n = 3). BFR may have lower efficacy than MIRT in this context—though a fully-powered trial is needed to definitively address this hypothesis.

scholarly journals Effects of therapeutic alliance on clinical outcomes in patients with symptomatic knee osteoarthritis undergoing an exercise program: A randomized clinical trial protocol

Medwave ◽  
2021 ◽  
Vol 21 (03) ◽  
pp. e8159-e8159
Author(s):  
Iván Cuyul-Vásquez ◽  
Jorge Fuentes C
Keyword(s):  
Clinical Trial ◽  
Knee Osteoarthritis ◽  
Therapeutic Alliance ◽  
Pain Intensity ◽  
Physical Therapists ◽  
Exercise Program ◽  
Therapeutic Exercise ◽  
Pressure Pain ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

Background Previous evidence has shown that seniors physical therapists applying electrotherapy and an enhanced therapeutic alliance in their sessions can positively influence the levels of analgesia of patients with chronic low back pain. It is currently unknown if these effects can be achieved in people with symptomatic knee osteoarthritis when receiving treatment focused on therapeutic exercise. Aim To determine the effects of different therapeutic alliance levels during the application of a therapeutic exercise program on pain intensity and pressure pain threshold in patients with symptomatic knee osteoarthritis. Method This will be a randomized, parallel, two-arm, clinical trial. An intervention of three sessions of therapeutic exercise will be applied for one week. Patients aged 45 to 65 years old with a clinical and radiographic diagnosis of knee osteoarthritis will participate. Also, patients with a pain intensity of at least three months duration and 3 to 8 points in a numerical rating scale will be included. Patients will be randomly assigned to a therapeutic exercise experimental group with an enhanced therapeutic alliance (e.g., active listening, personalized conversation, empathy) or limited therapeutic alliance (e.g., one-way verbalization, brief interaction). Physical therapists will be trained in delivering these two levels of the therapeutic alliance. The pressure pain thresholds at the symptomatic knee and the pain intensity will be measured before and after the intervention. Discussion The results of this research will determine the impact of the therapeutic alliance as a nonspecific relevant factor during the application of a therapeutic exercise program in the treatment of patients with symptomatic knee osteoarthritis. Clinical trials registration number NCT04390932

scholarly journals Long-Term (1-Year) Safety and Efficacy of a Single 6-mL Injection of Hylan G-F 20 in Indian Patients with Symptomatic Knee Osteoarthritis

2014 ◽  
Vol 8 (1) ◽  
pp. 54-68 ◽  
Author(s):  
Sarvajeet Pal ◽  
Sreedhar Thuppal ◽  
K.J Reddy ◽  
Sachin Avasthi ◽  
Anish Aggarwal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Knee Osteoarthritis ◽  
Medication Use ◽  
Treatment Phase ◽  
Safety And Efficacy ◽  
Knee Oa ◽  
Indian Patients ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

Introduction: The prevalence of symptomatic knee osteoarthritis (OA) among Asians ≥65 years is estimated to double by 2040. This study was designed to evaluate the safety and efficacy of a single, 6-mL intra-articular injection of hylan G-F 20 in Indian patients with knee OA at 26 weeks through to 52 weeks. Methods: This study was an open-label, multicentre, phase 4 clinical trial. Enrolled patients (N=394) were ≥30 years old with Kellgren-Lawrence grade 1–3 OA; all patients received hylan G-F 20. WOMAC, SF-12, PTGA, and COGA scores, and OA medication use were evaluated at weeks 1, 4, 12, 26, 39, and 52 (initial treatment phase). At 26, 39, or 52 weeks, eligible patients could participate in a repeat treatment phase. McNemar-Bowkers, paired t-tests and ANOVA analyses were performed (alpha=0.05). Results: At 26 weeks, statistically significant changes from baseline were observed in all efficacy parameters, including the primary efficacy endpoint of WOMAC A1 (p<0.0001). Improvements continued for 52 weeks. No significant changes occurred in concomitant medication use. Eleven patients (2.8%) were re-injected at week 26 or 52. After repeat injection, statistically significant decreases were observed in WOMAC A1, WOMAC C and PTGA scores (p≤0.028). Twenty-three (5.8%) patients reported 26 local target knee AEs. Conclusion: Among Indian patients within this study, a 6-mL hylan G-F 20 injection was well tolerated and effective in treating symptomatic knee OA with significant long-term (1 year) improvement of outcomes. When needed, repeat treatment was safe and efficacious for 4 weeks. Trial Registration: Clinical Trial Registry of India (CTRI/2010/091/000052) www.ctri.nic.in/Clinicaltrials/login.php.

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