scholarly journals Neurodevelopmental outcome of very preterm infants with gastrointestinal tract perforations does not differ compared to controls

2021 ◽  
Author(s):  
Michael F. Moser ◽  
Irina J. Müller ◽  
Johannes Schalamon ◽  
Bernhard Resch
Keyword(s):  
Birth Weight ◽  
Gastrointestinal Tract ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Neurodevelopmental Outcome ◽  
Low Birth Weight Infants ◽  
Very Preterm Infants ◽  
Iatrogenic Perforation ◽  
Late Onset Sepsis

Summary Purpose To evaluate gastrointestinal tract (GIT) perforations in very low birth weight infants and the effects on neurodevelopmental outcome. Methods Between 2000 and 2017 all cases with GIT perforation were analyzed regarding causes, associated morbidities and neurodevelopmental outcome and compared with matched (gestational age, birth weight, gender, year of birth) by 1:2 controls. Results The incidence of GIT perforation was 2.0% (n = 38/1878). Diagnoses associated with GIT were meconium obstruction of prematurity (MOP,n = 19/50%), spontaneous intestinal perforation (SIP, n = 7/18%), necrotizing enterocolitis (NEC, n = 6/16%), iatrogenic perforation (n = 3/8%), volvulus (n = 2/5%) and meconium ileus (n = 1/3%). The NEC-associated perforations occurred later compared to those associated with MOP and SIP (median 8 days and 6 days vs. 17 days, p = 0.001 and 0.023, respectively) and main localization was the terminal ileum (84%). Cases had higher rates of late onset sepsis (55% vs. 24%, p = 0.003), longer duration of mechanical ventilation (median 30 days vs 18 days, p = 0.013) and longer stays at the hospital (median 122 days vs 83 days, p < 0.001); mortality rates did not differ. The 2‑year neurodevelopment follow-up revealed no differences between groups (normal development 49% vs. 40%). Conclusion Despite increased morbidities preterm infants with GIT perforation did not have a higher mortality rate and groups did not differ regarding neurodevelopmental outcome at the corrected for prematurity age of 2 years.

64 PROCALCITONIN AS A SCREENING TEST IN LATE ONSET SEPSIS IN VERY LOW BIRTH WEIGHT PRETERM INFANTS.

2004 ◽  
Vol 52 (Suppl 2) ◽  
pp. S356.5-S356
Author(s):  
R. Vazzalwar ◽  
E. Pina-Rodriques ◽  
B. Puppala ◽  
P. Krieger ◽  
D. Angst ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Screening Test ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Late Onset Sepsis

scholarly journals Procalcitonin as a Screening Test for Late-Onset Sepsis in Preterm Very Low Birth Weight Infants

2005 ◽  
Vol 25 (6) ◽  
pp. 397-402 ◽  
Author(s):  
Ramesh Vazzalwar ◽  
Estela Pina-Rodrigues ◽  
Bhagya L Puppala ◽  
Denise B Angst ◽  
Lorene Schweig
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Screening Test ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Low Birth Weight Infants ◽  
Late Onset Sepsis

scholarly journals Practices related to late‐onset sepsis in very low‐birth weight preterm infants

2015 ◽  
Vol 91 (2) ◽  
pp. 168-174
Author(s):  
Maria Regina Bentlin ◽  
Ligia M.S.S. Rugolo ◽  
Ligia S.L. Ferrari
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Late Onset Sepsis

scholarly journals Practices related to late-onset sepsis in very low-birth weight preterm infants

2015 ◽  
Vol 91 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Maria Regina Bentlin ◽  
Ligia M.S.S. Rugolo ◽  
Ligia S.L. Ferrari
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Late Onset Sepsis

scholarly journals Oropharyngeal Administration of Colostrum Increases Salivary Secretory IgA Levels in Very Low-Birth-Weight Infants

2017 ◽  
Vol 34 (14) ◽  
pp. 1389-1395 ◽  
Author(s):  
Coleen Greecher ◽  
Kim Doheny ◽  
Kristen Glass
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Multicenter Trial ◽  
Secretory Iga ◽  
Control Group ◽  
Low Birth Weight Infants ◽  
Vlbw Infants ◽  
Late Onset Sepsis

Aim Oropharyngeal administration of colostrum (OAC) has been proposed to provide mother's early milk to very low-birth-weight (VLBW) infants in the first few days of life. The aim of this study was to test the hypothesis that OAC would increase salivary secretory IgA (SsIgA). Patients and Methods Overall, 30 VLBW infants randomized to receive OAC or sterile water had salivary sampling for SsIgA on the day of life (DOL) 2, 7, and 14. The incidence of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) was determined prospectively. Within and between-group comparisons were made by paired and independent samples t-tests. Results Baseline characteristics were similar between groups. SsIgA was higher in OAC versus the control group (p < 0.05) on DOL 7, but not subsequently on DOL 14. There was no difference in LOS or NEC. Conclusion OAC increased SsIgA at DOL 7. A large, multicenter trial is needed to determine if OAC decreases LOS or NEC in VLBW infants.

Clinicopathological Differences Between Early-onset and Late-onset Sepsis and Pneumonia in Very Low Birth Weight Infants

1990 ◽  
Vol 10 (5) ◽  
pp. 757-768 ◽  
Author(s):  
Kyoko Itoh ◽  
Hiroaki Aihara ◽  
Satoshi Takada ◽  
Masamitsu Nishino ◽  
Yokei Lee ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Early Onset ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Low Birth Weight Infants ◽  
Late Onset Sepsis

scholarly journals Nutritional Factors Associated with Late-Onset Sepsis in Very Low Birth Weight Newborns

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 196
Author(s):  
Juliany Caroline Silva de Sousa ◽  
Ana Verônica Dantas de Carvalho ◽  
Lorena de Carvalho Monte de Prada ◽  
Arthur Pedro Marinho ◽  
Kerolaynne Fonseca de Lima ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Enteral Nutrition ◽  
Parenteral Nutrition ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Growth Restriction ◽  
Low Birth Weight Infants ◽  
Late Onset Sepsis ◽  
Extrauterine Growth Restriction

Background: Delayed onset of minimal enteral nutrition compromises the immune response of preterm infants, increasing the risk of colonization and clinical complications (e.g., late-onset sepsis). This study aimed to analyze associations between late-onset sepsis in very low birth weight infants (<1500 g) and days of parenteral nutrition, days to reach full enteral nutrition, and maternal and nutritional factors. Methods: A cross-sectional study was carried out with very low birth weight infants admitted to a neonatal intensive care unit (NICU) of a reference maternity hospital of high-risk deliveries. Data regarding days of parenteral nutrition, days to reach full enteral nutrition, fasting days, extrauterine growth restriction, and NICU length of stay were extracted from online medical records. Late-onset sepsis was diagnosed (clinical or laboratory) after 48 h of life. Chi-squared, Mann–Whitney tests, and binary logistic regression were applied. Results: A total of 97 preterm infants were included. Of those, 75 presented late-onset sepsis with clinical (n = 40) or laboratory (n = 35) diagnosis. Maternal urinary tract infection, prolonged parenteral nutrition (>14 days), and extrauterine growth restriction presented 4.24-fold, 4.86-fold, and 4.90-fold higher chance of late-onset sepsis, respectively. Conclusion: Very low birth weight infants with late-onset sepsis had prolonged parenteral nutrition and took longer to reach full enteral nutrition. They also presented a higher prevalence of extrauterine growth restriction than infants without late-onset sepsis.

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