Association between inflammatory biomarkers and acute respiratory distress syndrome or acute lung injury risk

Summary Background The relationship between acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) and levels of certain inflammatory factors remains controversial. The purpose of this meta-analysis was to summarize the available studies evaluating the association between levels of inflammatory factors and ARDS/ALI incidence. Methods We searched the PubMed, EmBase, and Cochrane databases for studies published up to July 2017. For each inflammatory factor, a random effects model was employed to pool results from different studies. Results We identified 63 studies that included 6243 patients in our meta-analysis. Overall, the results indicated that the levels of angiopoietin (ANG)-2 (standard mean difference, SMD: 1.34; P < 0.001), interleukin (IL)-1β (SMD: 0.92; P = 0.012), IL‑6 (SMD: 0.66; P = 0.005), and tumor necrosis factor (TNF)-α (SMD: 0.98; P = 0.001) were significantly higher in patients with ARDS/ALI than in unaffected individuals. No significant differences were observed between patients with ARDS/ALI and unaffected individuals in terms of the levels of IL‑8 (SMD: 0.61; P = 0.159), IL-10 (SMD: 1.10; P = 0.231), and plasminogen activator inhibitor (PAI)-1 (SMD: 0.70; P = 0.060). Conclusions ARDS/ALI is associated with a significantly elevated levels of ANG‑2, IL-1β, IL‑6, and TNF‑α, but not with IL‑8, IL-10, and PAI‑1 levels.

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Association Between Inflammatory Biomarkers and Acute Respiratory Distress Syndrome or Acute Lung Injury Risk: A Systematic Review and Meta-analysis

10.21203/rs.3.rs-21170/v1 ◽

2020 ◽

Author(s):

Quoqi Zhou ◽

Zhenfeng Liu ◽

Daishun Liu ◽

Yugang Zou ◽

Haixia Wang ◽

...

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Acute Lung Injury ◽

Lung Injury ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Meta Analysis ◽

Inflammatory Factors ◽

Tnf Α ◽

Pai 1

Abstract BackgroundThe relationship between acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) and levels of certain inflammatory factors remains controversial. The purpose of this meta-analysis was to summary the available studies evaluated the association between levels of inflammatory factors and ARDS/ALI incidence.MethodsWe searched the PubMed, EmBase, and Cochrane databases for studies published in or before July 2017. For each inflammatory factor, a random effects model was employed to pool results from different studies.ResultsWe identified 63 studies that included 6,243 patients in our meta-analysis. Overall, the results indicated that the levels of angiopoietin (ANG)-2 [standard mean difference (SMD): 1.34; P < 0.001], interleukin (IL)-1β (SMD: 0.92; P = 0.012), IL-6 (SMD: 0.66; P = 0.005), and tumour necrosis factor (TNF)-α (SMD: 0.98; P = 0.001) were significantly higher in patients with ARDS/ALI than in unaffected individuals. No significant differences were observed between patients with ARDS/ALI and unaffected individuals in terms of the levels of IL-8 (SMD: 0.61; P = 0.159), IL-10 (SMD: 1.10; P = 0.231), and plasminogen activator inhibitor (PAI)-1 (SMD: 0.70; P = 0.060).ConclusionsOur findings indicated that ARDS/ALI were associated with elevated levels of ANG-2, IL-1β, IL-6, and TNF-α, but not with IL-8, IL-10, and PAI-1 levels.

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Diagnostic value of miR-155 for acute lung injury/acute respiratory distress syndrome in patients with sepsis

Journal of International Medical Research ◽

10.1177/0300060520943070 ◽

2020 ◽

Vol 48 (7) ◽

pp. 030006052094307

Author(s):

Zhou-Feng Wang ◽

Yu-Min Yang ◽

Heng Fan

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Acute Lung Injury ◽

Lung Injury ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Characteristic Curve ◽

Diagnostic Value ◽

Inflammatory Factors ◽

Tnf Α

Objective We aimed to investigate the diagnostic value of microRNA-155 (miR-155) for acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) in patients with sepsis. Methods In this prospective study, we used Spearman correlation analysis to investigate relationships between miR-155 expression and inflammatory factors, oxygenation ratio (PaO2/FiO2), and ALI/ARDS score, and used area under the receiver operating characteristic curve (AU-ROC) to evaluate miR-155's diagnostic accuracy for ALI/ARDS in patients with sepsis. Results In total, 156 patients with sepsis were enrolled in our study, of which 41 had ALI and 32 had ARDS. miR-155 expression in plasma of patients with sepsis and ALI/ARDS was significantly higher than that of patients with sepsis but no ALI/ARDS. The miR-155 level in patients with sepsis and ALI/ARDS was positively correlated with interleukin (IL)-1β and tumor necrosis factor (TNF)-α levels and ALI/ARDS score, but negatively correlated with PaO2/FiO2. The AU-ROC of plasma miR-155 for diagnosis of sepsis with ALI/ARDS was 0.87, and plasma miR-155, IL-1β, and TNF-α had high sensitivity and specificity for the diagnosis of sepsis with ALI/ARDS. Conclusion miR-155 is highly expressed in plasma of patients with septic ALI/ARDS; it is positively correlated with lung function and can be used for early diagnosis.

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