Role of endoscopic retrograde pancreatography for early detection of pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm of the pancreas

2012 ◽  
Vol 20 (3) ◽  
pp. 356-361 ◽  
Author(s):  
Takao Ohtsuka ◽  
Noboru Ideno ◽  
Teppei Aso ◽  
Yosuke Nagayoshi ◽  
Hiroshi Kono ◽  
...  
Keyword(s):  
Early Detection ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Ductal Adenocarcinoma ◽  
Endoscopic Retrograde Pancreatography ◽  
Endoscopic Retrograde ◽  
Mucinous Neoplasm

scholarly journals Utility of endoscopic transpapillary pancreatic cyst drainage for intraductal papillary mucinous neoplasm infection

2021 ◽  
Vol 14 (6) ◽  
pp. e242583
Author(s):  
Shunsuke Watanabe ◽  
Masao Toki ◽  
Junji Shibahara ◽  
Tadakazu Hisamatsu
Keyword(s):  
Intraductal Papillary Mucinous Neoplasm ◽  
Cyst Wall ◽  
Pancreatic Cyst ◽  
Epigastric Pain ◽  
Drainage Tube ◽  
Endoscopic Drainage ◽  
Endoscopic Retrograde Pancreatography ◽  
Endoscopic Retrograde ◽  
Mucinous Neoplasm ◽  
Route Of Infection

A 61-year-old woman with intraductal papillary mucinous neoplasm (IPMN) infection, who was treated with antibiotics, developed IPMN reinfection with febrile epigastric pain and was febrile. CT showed that the diameter of the IPMN had grown and hardened, with thickening of the cyst wall. Endoscopic retrograde pancreatography was then performed and a nasopancreatic cyst drainage tube was placed into the cyst. Symptoms and inflammatory findings improved considerably 17 days after endoscopic drainage. Few reports and evidence have been found regarding IPMN infections, and the frequency of onset, route of infection and optimal drainage method remain unknown. This study indicated that endoscopic transpapillary pancreatic cyst drainage was effective and is highly recommended for IPMN infection.

scholarly journals Evaluation of SOX9 Expression in Pancreatic Ductal Adenocarcinoma and Intraductal Papillary Mucinous Neoplasm

Pancreas ◽  
2013 ◽  
Vol 42 (3) ◽  
pp. 488-493 ◽  
Author(s):  
Takayuki Tanaka ◽  
Tamotsu Kuroki ◽  
Tomohiko Adachi ◽  
Shinichiro Ono ◽  
Masataka Hirabaru ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Ductal Adenocarcinoma ◽  
Sox9 Expression ◽  
Mucinous Neoplasm

Expression of GRP78 protein in pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasm.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 323-323
Author(s):  
Asha R. Dhanarajan ◽  
Reginald Hill ◽  
Sam G. Pappas ◽  
Gerard J. Abood ◽  
Jennifer Lynn Gnerlich ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Protein Quality ◽  
Expression Level ◽  
Ductal Adenocarcinoma ◽  
Pancreatic Ducts ◽  
Low Grade ◽  
Ductal Cells ◽  
Mucinous Neoplasm ◽  
Significant Difference

323 Background: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis due to late detection, aggressive biology and resistance to chemotherapy. Markers for early detection of PDAC and mediators of chemoresistance are poorly understood. GRP78 is a major endoplasmic reticulum (ER) chaperone protein critical for protein quality control of the ER. Increased GRP78 expression promotes in vitro cancer cell survival, progression, and chemoresistance. This study aims to examine expression of GRP78 protein in PDAC and intraductal papillary mucinous neoplasm (IPMN) compared to normal pancreatic ducts using immunohistochemistry (IHC). Methods: The expression of GRP78 was assessed using IHC in 93 sections of formalin-fixed paraffin-embedded tissue: normal ducts (38), low grade IPMN (IPMN-LG, 26), high grade IPMN (IPMN-HG, 9), and PDAC (20). Immunostaining intensity of GRP78 protein was categorized as no or weak staining (0-1+) and strong staining (2-3+). Fisher’s exact test with two tails was performed using the GraphPad statistical software. Results: GRP78 expression was identified in the cytoplasm of normal pancreatic ducts, IPMN and PDAC with a fine granular pattern. All PDAC and IPMN-HG showed strong expression of GRP78 while the normal ductal cells showed only minimal expression of GRP78. 73% of IPMN-LG expresses GRP78 strongly. Statistical analysis revealed a significant difference in GRP78 expression level between normal ductal cells and all three pathological conditions including PDCA, IPMN-HG and IPMN-LG (all p < 0.0001). Conclusions: This study shows that the expression level of GRP78 is significantly increased in PDAC, IPMN-HG and IPMN-LG compared to normal ductal cells. There appears to be a progressive increase in GRP78 expression from IPMN-LG to IPMN-HG and invasive PDAC. Increased GRP78 expression may be a marker for those at risk of developing PDAC. Changes in GRP78 expression over time and its role in PDAC chemoresistance should be further assessed. [Table: see text]

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