scholarly journals Oral branched-chain amino acid granules improve structure and function of human serum albumin in cirrhotic patients

2016 ◽  
Vol 52 (6) ◽  
pp. 754-765 ◽  
Author(s):  
Hiroko Setoyama ◽  
Motohiko Tanaka ◽  
Kohei Nagumo ◽  
Hideaki Naoe ◽  
Takehisa Watanabe ◽  
...  
Keyword(s):  
Amino Acid ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Structure And Function ◽  
Branched Chain Amino Acid ◽  
Cirrhotic Patients ◽  
Branched Chain ◽  
And Function

scholarly journals Influence of aqueous extracts of urban airborne particulate matter on the structure and function of human serum albumin

2020 ◽  
Vol 263 ◽  
pp. 114667 ◽  
Author(s):  
Olga Mazuryk ◽  
Przemysław Gajda-Morszewski ◽  
Monika Flejszar ◽  
Przemysław Łabuz ◽  
Rudi van Eldik ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Airborne Particulate Matter ◽  
Structure And Function ◽  
Aqueous Extracts ◽  
Airborne Particulate ◽  
And Function

scholarly journals Understanding the effects of two bound glucose in Sudlow site I on structure and function of human serum albumin: theoretical studies

2016 ◽  
Vol 35 (4) ◽  
pp. 781-790 ◽  
Author(s):  
Tadsanee Awang ◽  
Nuttapon Wiriyatanakorn ◽  
Patchreenart Saparpakorn ◽  
Deanpen Japrung ◽  
Prapasiri Pongprayoon
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Structure And Function ◽  
Theoretical Studies ◽  
And Function

A novel 3D-printed centrifugal ultrafiltration method reveals in vivo glycation of human serum albumin decreases its binding affinity for zinc

Metallomics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1036-1043 ◽  
Author(s):  
Monica J. Jacobs ◽  
Cody W. Pinger ◽  
Andre D. Castiaux ◽  
Konnor J. Maloney ◽  
Dana M. Spence
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
High Glucose ◽  
Plasma Proteins ◽  
Structure And Function ◽  
3D Printed ◽  
And Function ◽  
Centrifugal Ultrafiltration

Plasma proteins are covalently modified in vivo by the high-glucose conditions in the bloodstreams of people with diabetes, resulting in changes to both structure and function.

scholarly journals Notes On Synthesis Of Perdeutero-5-13C,5,5,5-Trifluoroisoleucine VI

2017 ◽  
Author(s):  
David Naugler ◽  
Robert Scott Prosser
Keyword(s):  
Protein Structure ◽  
Amino Acid ◽  
Structure And Function ◽  
Methyl Groups ◽  
Nmr Studies ◽  
Branched Chain Amino Acid ◽  
Acid Methyl ◽  
Deuterated Proteins ◽  
Branched Chain ◽  
And Function

The 13CF3 group is a promising label for heteronuclear (19F,13C) NMR studies of proteins. Desirable locations for this NMR spin label include the branched chain amino acid methyl groups. It is known that replacement of CH3 by CF3 at such locations preserves protein structure and function and enhances stability. In particular, 13CF3 may be introduced at the δ position of isoleucine and incorporated biosynthetically in highly deuterated proteins. This paper reports our work in synthesis and purification of 5,5,5-trifluoroisoleucine, its perdeutero and 5-13C versions and of 2-13C-trifluoroacetate and its utility as a precursor for introduction of the 13CF3 group into proteins.

Studies on the synergistic action of methylglyoxal and peroxynitrite on structure and function of human serum albumin

2021 ◽  
pp. 1-14
Author(s):  
Akhlas Tarannum ◽  
Zarina Arif ◽  
Mohd Mustafa ◽  
Faizan Abul Qais ◽  
Safia Habib ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Structure And Function ◽  
Synergistic Action ◽  
And Function

Investigations on the effects of Cu2+ on the structure and function of human serum albumin

Luminescence ◽  
2015 ◽  
Vol 31 (2) ◽  
pp. 557-564 ◽  
Author(s):  
Mingyang Jing ◽  
Rutao Liu ◽  
Wenbao Yan ◽  
Xuejie Tan ◽  
Yadong Chen
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Structure And Function ◽  
And Function

scholarly journals Oxidative Alteration of Trp-214 and Lys-199 in Human Serum Albumin Increases Binding Affinity with Phenylbutazone: A Combined Experimental and Computational Investigation

2018 ◽  
Vol 19 (10) ◽  
pp. 2868 ◽  
Author(s):  
Luiza Bertozo ◽  
Ernesto Tavares Neto ◽  
Leandro Oliveira ◽  
Valdecir Ximenes
Keyword(s):  
Amino Acid ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Interaction Energy ◽  
Score Function ◽  
Oxidation Products ◽  
Amino Acid Residues ◽  
Computational Investigation ◽  
A Current

Human serum albumin (HSA) is a target for reactive oxygen species (ROS), and alterations of its physiological functions caused by oxidation is a current issue. In this work, the amino-acid residues Trp-214 and Lys-199, which are located at site I of HSA, were experimentally and computationally oxidized, and the effect on the binding constant with phenylbutazone was measured. HSA was submitted to two mild oxidizing reagents, taurine monochloramine (Tau-NHCl) and taurine dibromamine (Tau-NBr2). The oxidation of Trp-214 provoked spectroscopic alterations in the protein which were consistent with the formation of N′-formylkynurenine. It was found that the oxidation of HSA by Tau-NBr2, but not by Tau-NHCl, provoked a significant increase in the association constant with phenylbutazone. The alterations of Trp-214 and Lys-199 were modeled and simulated by changing these residues using the putative oxidation products. Based on the Amber score function, the interaction energy was measured, and it showed that, while native HSA presented an interaction energy of −21.3 kJ/mol, HSA with Trp-214 altered to N′-formylkynurenine resulted in an energy of −28.4 kJ/mol, and HSA with Lys-199 altered to its carbonylated form resulted in an energy of −33.9 kJ/mol. In summary, these experimental and theoretical findings show that oxidative alterations of amino-acid residues at site I of HSA affect its binding efficacy.

scholarly journals Is administrating branched-chain amino acid-enriched nutrition achieved symptom-free in malnourished cirrhotic patients?

2014 ◽  
Vol 54 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Yasuhiro Tsuda ◽  
Hideo Fukui ◽  
Tetsuya Sujishi ◽  
Hideko Ohama ◽  
Yusuke Tsuchimoto ◽  
...  
Keyword(s):  
Amino Acid ◽  
Branched Chain Amino Acid ◽  
Cirrhotic Patients ◽  
Branched Chain
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