One more new gastric disease induced by Helicobacter pylori infection, enterochromaffin-like (ECL) cell carcinoid tumor

1999 ◽  
Vol 34 (4) ◽  
pp. 545-546 ◽  
Author(s):  
Tsutomu Chiba
2016 ◽  
Vol 29 (7-8) ◽  
pp. 476 ◽  
Author(s):  
Elisabete Coelho ◽  
Ana Magalhães ◽  
Mário Dinis-Ribeiro ◽  
Celso A. Reis

Introduction: Helicobacter pylori infection is very prevalent worldwide and is associated with the progression of the gastriccarcinogenesis cascade, being one of the main risk factors for the development of gastric carcinoma. Several factors are determinant for the infection and for the development of gastric disease, including environmental factors, host genetic factors and virulence factors of the bacteria.Material and Methods: In this review, we present an overview of the current knowledge on the determinants of the infection and on the recently described molecular mechanisms of Helicobacter pylori adhesion to the gastric mucosa, as well as its possible future therapeutic application.Results: The adhesion of Helicobacter pylori to the gastric epithelium is critical for gastric pathogenesis, allowing bacterial access to nutrients and the action of bacterial virulence factors, promoting recurrence of the infection and the progression of the gastric carcinogenesis pathway.Discussion: Eradication of Helicobacter pylori infection is the best preventive strategy available against gastric cancer, mainly if it is achieved before the development of pre-neoplastic lesions. The increase in antibiotics resistance, together with the eradication failures in some patients, has promoted the development of alternative treatments.Conclusion: The new therapeutic strategies, focused on the molecular mechanism of Helicobacter pylori adhesion, are very promising; however, future studies are needed to evaluate its in vivo efficiency and toxicity.


2017 ◽  
Vol 11 (1) ◽  
Author(s):  
Richard Ballweg ◽  
Frederick Schozer ◽  
Kelsey Elliott ◽  
Alexander Kuhn ◽  
Logan Spotts ◽  
...  

PROTEOMICS ◽  
2002 ◽  
Vol 2 (3) ◽  
pp. 313 ◽  
Author(s):  
Gaby Haas ◽  
Galip Karaali ◽  
Karl Ebermayer ◽  
Wolfram G. Metzger ◽  
Stephanie Lamer ◽  
...  

2012 ◽  
Vol 13 (10) ◽  
pp. 5043-5046 ◽  
Author(s):  
Wen-Hua Zhang ◽  
Xiao-Jing Wu ◽  
Jing-Xiu Niu ◽  
Hao Yan ◽  
Xin-Zhuo Wang ◽  
...  

2000 ◽  
Vol 15 (12) ◽  
pp. H2-H2
Author(s):  
IS Mertasudira ◽  
JR Saketi ◽  
A. Djumhana ◽  
J. Widjojo ◽  
SA Abdurachman

2000 ◽  
Vol 15 (12) ◽  
pp. H10-H11
Author(s):  
Budi Purnomo ◽  
Eva J. Soeleman ◽  
Hadjat S. Digdowirogo ◽  
Hartati N. Soehardjo

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