Is ventilator-induced lung injury a promoter of multiple organ failure in adult respiratory distress syndrome? The effect of permissive hypercapnia on oxygenation and outcome

1997 ◽  
Vol 11 (1) ◽  
Author(s):  
Keith G. Hickling
Keyword(s):  
Lung Injury ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Adult Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Multiple Organ ◽  
Permissive Hypercapnia ◽  
Ventilator Induced Lung Injury

The Inflammatory Response

1992 ◽  
Vol 7 (2) ◽  
pp. 53-66 ◽  
Author(s):  
John G. Williams ◽  
Ronald V. Maier
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Adult Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Medical Center ◽  
Healing Process ◽  
Multiple Organ ◽  
Inflammatory Stimuli

Inflammation is a critical component of the normal healing process. In the patient with extensive injury or infection, however, this same process may lead to organ dysfunction and failure as seen in adult respiratory distress syndrome and multiple organ failure syndrome. In this article we review: (1) the evolution of current concepts of inflammation; (2) individual elements of the host response to inflammatory stimuli; and (3) current strategies for the prevention and treatment of adult respiratory distress syndrome and multiple organ failure syndrome. From the Department of Surgery, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA.

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