Abstract
Background: Primary sacral tumors (PST) are a rare group of skeletal tumors that can affect children and adults of all ages. Little is known about the epidemiological characteristics of PST in China.Methods: 1385 patients with primary sacral tumors, which had the clinical record at our bone tumor center from 2000 to November 2018 were analyzed.Results: 51.7% (716 cases) were malignant and 48.3 % (669 cases) were benign. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma and other histologic types. The most common histological type of benign tumors was giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had the gender predilection. Chordoma, chondrosarcoma, myeloma and osteosarcoma of PST affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma and epidermoid cyst more frequently affected females than males.Conclusions: The large cohort of primary sacral tumors in our database may reveal their epidemiologic characteristics of primary sacral malignant and benign tumors in China and epidemiological feature of PST is fairly distinct from the mobile spine and extremities.
The values of receptor activator nuclear Kappa-B ligand expression in stage III giant cell tumor of the bone
