Comparing clinical outcomes between extended curettage and wide resection in Enneking stage 3 giant cell tumor of bone

2021 ◽  
Author(s):  
Pakjai Tuntarattanapong ◽  
Pongsiri Piakong ◽  
Thanapon Chobpenthai ◽  
Bhasanan Sukanthanak ◽  
Piya Kiatisevi
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Clinical Outcomes ◽  
Cell Tumor ◽  
Wide Resection ◽  
Extended Curettage ◽  
Enneking Stage

scholarly journals Multiple Pulmonary Metastases of Giant Cell Tumor of Bone with expression of VEGFR-2 Successfully Treated by Denosumab and Apatinib: A Rare Case Report

2021 ◽  
Author(s):  
taojun gong ◽  
Yi Luo ◽  
Yitian Wang ◽  
Chuanxi Zheng ◽  
Jianguo Fang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Local Recurrence ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Pulmonary Metastases ◽  
Cell Tumor ◽  
Wide Resection ◽  
High Tendency ◽  
Bony Destruction

Abstract Background: Giant cell tumor of bone (GCTB) is a rare benign but locally aggressive bone tumor. It has a high tendency for local recurrence, which may increase the occurrence of lung metastasis. Currently, the treatment of pulmonary metastases of GCTB is controversial. Denosumab is the preferred regimen for unresectable metastatic lesions, but there are no alternative treatment options when denosumab is resistant. So far, no case reports of metastatic GCTB treated with denosumab and apatinib have been published. Case presentation: This is a case report of a 26-year-old female who experienced right knee pain for over 6 months. Radiography and computed tomography revealed osteolytic bony destruction in the proximal right tibia. Using histological, radiological, and clinical techniques, a diagnosis of GCTB was achieved. Meanwhile, the immunohistochemical stain-identified the tumor cells were positive for vascular endothelial growth factor receptor 2 (VEGFR-2). After intralesional curettage of the primary tumor and wide resection of local recurrence surgeries, she developed recurrent hemoptysis. Chest computed tomography (CT) images showed multiple pulmonary nodules. She was administrated denosumab therapy but disease progression was confirmed after four months of treatment. She then received denosumab and apatinib therapy for 24 months, after a partial response was achieved.Conclusions: We depict a case of multiple pulmonary metastases of GCTB successfully controlled by denosumab and apatinib therapy. VEGFR-2 may be an effective therapeutic target for GCTB with pulmonary metastasis when denosumab is ineffective.

Bilateral Lung Metastases From a Phalangeal Giant Cell Tumor of Bone

2020 ◽  
pp. 109352662096435
Author(s):  
Annie Orr ◽  
Huifei Liu ◽  
Rachel Mariani ◽  
Jennifer H Aldrink ◽  
Bhuvana A Setty ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Residual Disease ◽  
Lung Metastases ◽  
Transcriptome Profiling ◽  
Cell Tumor ◽  
Wide Resection ◽  
Genetic Changes ◽  
Metastatic Lung ◽  
Bilateral Lung

We describe a rare pediatric case of a phalangeal giant cell tumor of bone with extensive bilateral lung metastases following curettage, wide resection, and amputation. Concurrent peripheral blood eosinophilia and pleural effusion with marked eosinophilia (47%) were present. To discover genetic changes driving tumor metastasis, genomic and transcriptome profiling of the metastatic lung mass as well as germline analysis were performed. Whole exome sequencing detected a histone H3F3A p.G35V missense mutation in tumor cells. RNA sequencing revealed overexpression of receptor activator of nuclear factor kappa-B ligand (RANKL). The patient is alive with no residual disease and uncompromised respiratory function 29 months after amputation of primary tumor and 19 months after surgical resection of his metastatic lung disease.

Total spondylectomy for Enneking stage III giant cell tumor of the mobile spine

2018 ◽  
Vol 27 (12) ◽  
pp. 3084-3091 ◽  
Author(s):  
Noriaki Yokogawa ◽  
Hideki Murakami ◽  
Satoru Demura ◽  
Satoshi Kato ◽  
Katsuhito Yoshioka ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Stage Iii ◽  
Mobile Spine ◽  
Enneking Stage

EXCISION OF GIANT CELL TUMOR FOLLOWED BY RECONSTRUCTION OF DISTAL RADIUS USING FREE VASCULARIZED FIBULAR GRAFT

2019 ◽  
Vol 1 (4) ◽  
Author(s):  
Prisca Oriana Sutanto ◽  
Agus Roy Rusli Hamid ◽  
Adinda Putra Pradhana
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Distal Radius ◽  
Tumor Resection ◽  
Cell Tumor ◽  
Wide Resection ◽  
Fibular Graft ◽  
Maximum Function ◽  
Vascularized Fibular Graft ◽  
Free Vascularized Fibular Graft

Giant cell tumor (GCT) of the distal radius is a rare and unpredictable lesion. The aim of treatment is complete removal of the tumor and preservation of the maximum function of the extremity. Lower rates of local recurrence have been noted after wide resection of the diseased bone. Its standard treatment has ranged from surgical curettage to wide resection. One method for closing the defect is using the head of the fibula as a substitute for the distal radius. The healing of vascularized fibular graft is very quick and without bone resorption. Thus, in the procedure for reconstruction and limb salvage after bone tumor resection of the distal radius, the free vascularized fibular graft with the fibular head is an ideal substitute. This case report will show a patient with GCT that successfully treated by an excision of GCT followed by reconstruction of distal radius using free vascularized fibular graft.

scholarly journals Giant Cell Tumor of the Metacarpal: Case Report

Hand ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. NP113-NP117 ◽  
Author(s):  
Laura W. Lewallen ◽  
Eric R. Wagner ◽  
Steven L. Moran
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Treatment Options ◽  
Cell Tumor ◽  
Lytic Lesion ◽  
Wide Resection ◽  
Intralesional Curettage ◽  
Female Predominance ◽  
Long Term Follow Up ◽  
Small Bones

Background: Giant cell tumor (GCT) of bone is a benign, though locally aggressive tumor, classically described as an eccentric lytic lesion, often with cortical expansion and destruction. It typically involves the metaphysis or epiphysis of long bones in skeletally mature patients, with a slight female predominance. The incidence in the small bones of the hand has been reported to be 2% to 5%. Methods: Treatment options have evolved in recent years, and currently include intralesional curettage with or without adjuvant therapy, wide resection, and occasionally amputation. Results: In this report, we present a long-term follow-up (10 years) of a patient with GCT involving a metacarpal, who was initially reconstructed with a metacarpal head allograft, which was eventually revised to a metacarpophalangeal (MCP) total joint arthroplasty. Conclusions: To our knowledge, this is the only report of pyrocarbon being used for tumor reconstruction and the only report of late MCP allograft salvage.

scholarly journals Three-dimensional-printed porous implant combined with autograft reconstruction for giant cell tumor in proximal tibia

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yuqi Zhang ◽  
Minxun Lu ◽  
Li Min ◽  
Jie Wang ◽  
Yitian Wang ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Clinical Outcomes ◽  
Subchondral Bone ◽  
Proximal Tibia ◽  
Three Dimensional ◽  
Cell Tumor ◽  
Short Term ◽  
Porous Implant ◽  
The Mean

Abstract Background This study is to describe the design and surgical techniques of three- dimensional-printed porous implants for proximal giant cell tumors of bone and evaluate the short-term clinical outcomes. Methods From December 2016 to April 2020, 8 patients with giant cell tumor of bone in the proximal tibia underwent intralesional curettage of the tumor and reconstruction with bone grafting and three-dimensional-printed porous implant. Detailed anatomy data were measured, including the size of lesion and thickness of the subchondral bone. Prostheses were custom-made for each patient by our team. All patients were evaluated regularly and short-term clinical outcomes were recorded. Results The mean follow-up period was 26 months. According to the different defect sizes, the mean size of the plate and mean length of strut were 35 × 35 mm and 20 mm, respectively. The mean affected subchondral bone percentage was 31.5%. The average preoperative and postoperative thickness of the subchondral bone was 2.1 mm and 11.1 mm, respectively. There was no wound infection, skin necrosis, peroneal nerve injury, or other surgical related complications. No degeneration of the knee joint was found. Osseointegration was observed in all patients. The MSTS improved from an average of 12 preoperatively to 28 postoperatively. Conclusion The application of three-dimensional-printed printed porous prosthesis combined autograft could supply enough mechanical support and enhance bone ingrowth. The design and operation management lead to satisfactory subchondral bone reconstruction.

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