Is detethering necessary before deformity correction in congenital scoliosis associated with tethered cord syndrome: a meta-analysis of current evidence

2020 ◽  
Author(s):  
Kaustubh Ahuja ◽  
Syed Ifthekar ◽  
Samarth Mittal ◽  
Gagandeep Yadav ◽  
P. Venkata Sudhakar ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Deformity Correction ◽  
Tethered Cord ◽  
Congenital Scoliosis ◽  
Tethered Cord Syndrome ◽  
Current Evidence

scholarly journals Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Xudong Wang ◽  
Yangke Yu ◽  
Ningning Yang ◽  
Lei Xia
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Tethered Cord ◽  
Congenital Scoliosis ◽  
Cochrane Library ◽  
Resonance Imaging ◽  
R Software ◽  
Dural Ectasia ◽  
Magnetic Resonance Imaging Mri

Abstract Objective This is the first systematic review and meta-analysis on the overall incidence of intraspinal abnormalities in patients with congenital scoliosis (CS) and potential influencing factors. Methods We searched three large electronic databases (PubMed, EMBASE, and Cochrane Library) for potentially relevant studies. The quality of the included studies was assessed independently by two authors using the Methodological Index for Non-Randomized Studies (MINORS) criteria. Data on the number of CS patients, number of CS patients with intraspinal abnormalities, sex of the patients, and CS types were extracted from the included studies. R software was used to pool and analyze all the extracted data. Results This meta-analysis included 10 articles, and 671 of 1863 CS patients undergoing magnetic resonance imaging (MRI) examinations were identified to have intraspinal abnormalities. The overall incidence of intraspinal abnormalities in the patients with CS was 37% (95% CI, 29–45%). Diastematomyelia was the most common intraspinal abnormality and was detected in 45.60% of the patients with intraspinal abnormalities (306/671). The remaining intraspinal abnormalities included syringomyelia (273/671, 40.69%), tethered cord (190/671, 28.32%), low conus (58/671, 8.64%), intraspinal mass (39/671, 5.81%), Chiari malformation (32/671, 4.77%), fatty filum (27/671, 4.02%), spina bifida (occulta excluded) (17/671, 2.53%), tumor (17/671, 2.53%), cyst (12/671, 1.79%), syringomyelus (4/671, 0.60%), dural ectasia (1/671, 0.15%), and undiagnosed cord MRI hyperintensity (1/671, 0.15%). The patient’s sex and CS type were not factors that affected the incidence of intraspinal abnormalities in CS patients (all P > 0.05). Conclusions This meta-analysis revealed that the overall incidence of intraspinal abnormalities detected by MRI in CS patients was 37%. Diastematomyelia was the most common intraspinal abnormality. The patient’s sex and CS type were not factors that affected the incidence of intraspinal abnormalities in CS patients.

Spine-shortening osteotomy for patients with tethered cord syndrome: a systematic review and meta-analysis

2018 ◽  
Vol 40 (5) ◽  
pp. 340-363 ◽  
Author(s):  
Weiwei Lin ◽  
Hongtao Xu ◽  
Guman Duan ◽  
Jinjin Xie ◽  
Yisheng Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Tethered Cord ◽  
Tethered Cord Syndrome ◽  
Shortening Osteotomy

Surgical Treatment of Tethered Cord Syndrome in Adults: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 137 ◽  
pp. e221-e241 ◽  
Author(s):  
Kyle P. O'Connor ◽  
Adam D. Smitherman ◽  
Camille K. Milton ◽  
Ali H. Palejwala ◽  
Victor M. Lu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Surgical Treatment ◽  
Meta Analysis ◽  
Tethered Cord ◽  
Tethered Cord Syndrome

scholarly journals A meta-analysis comparing short-term weight and cardiometabolic changes between olanzapine/samidorphan and olanzapine

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Manit Srisurapanont ◽  
Sirijit Suttajit ◽  
Surinporn Likhitsathian ◽  
Benchalak Maneeton ◽  
Narong Maneeton
Keyword(s):  
Weight Gain ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Dropout Rates ◽  
Lower Percentage ◽  
Current Evidence ◽  
Weight Changes ◽  
Short Term ◽  
Short Term Treatment

AbstractThis study compared weight and cardiometabolic changes after short-term treatment of olanzapine/samidorphan and olanzapine. Eligible criteria for an included trial were ≤ 24 weeks, randomized controlled trials (RCTs) that compared olanzapine/samidorphan and olanzapine treatments in patients/healthy volunteers and reported weight or cardiometabolic outcomes. Three databases were searched on October 31, 2020. Primary outcomes included weight changes and all-cause dropout rates. Standardized mean differences (SMDs) and risk ratios (RRs) were computed and pooled using a random-effect model. This meta-analysis included four RCTs (n = 1195). The heterogeneous data revealed that weight changes were not significantly different between olanzapine/samidorphan and olanzapine groups (4 RCTs, SDM = − 0.19, 95% CI − 0.45 to 0.07, I2 = 75%). The whole-sample, pooled RR of all-cause dropout rates (4 RCTs, RR = 1.02, 95% CI 0.84 to 1.23, I2 = 0%) was not significant different between olanzapine/samidorphan and olanzapine groups. A lower percentage of males and a lower initial body mass index were associated with the greater effect of samidorphan in preventing olanzapine-induced weight gain. Current evidence is insufficient to support the use of samidorphan to prevent olanzapine-induced weight gain and olanzapine-induced cardiometabolic abnormalities. Samidorphan is well accepted by olanzapine-treated patients.

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