Bilirubin Calculi Crushing by Laser Irradiation at a Molecular Oscillating Region Wavelength Based on Infrared Absorption Spectrum Analysis Using a Free-Electron Laser: An Experimental Study

Surgery Today ◽  
2001 ◽  
Vol 31 (7) ◽  
pp. 626-633 ◽  
Author(s):  
Manabu Watanabe ◽  
Hirohisa Kajiwara ◽  
Kunio Awazu ◽  
Katsuo Aizawa
Keyword(s):  
Experimental Study ◽  
Absorption Spectrum ◽  
Laser Irradiation ◽  
Infrared Absorption ◽  
Spectrum Analysis ◽  
Free Electron ◽  
Free Electron Laser ◽  
Infrared Absorption Spectrum

Medical application of an infrared free-electron laser: selective removal of cholesterol ester in carotid artery atheromatous plaques

2006 ◽  
Vol 104 (3) ◽  
pp. 426-428 ◽  
Author(s):  
Yoshikazu Nakajima ◽  
Koichi Iwatsuki ◽  
Katsunori Ishii ◽  
Sachiko Suzuki ◽  
Toshiyuki Fujinaka ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Infrared Absorption ◽  
Free Electron ◽  
Free Electron Laser ◽  
Cholesterol Ester ◽  
Irradiation Time ◽  
Infrared Absorption Spectrum ◽  
Medical Application ◽  
Atheromatous Plaques ◽  
Human Carotid

Object The purpose of this study was to determine the effectiveness of infrared free-electron laser (FEL) irradiation of cholesterol esters in human carotid artery (CA) atheromas. Methods The degradation of cholesterol ester was estimated from changes in the infrared absorption spectra acquired using microscopic transmission Fourier transform infrared spectroscopy. An FEL emitting radiation at 5.75-μm wavelengths and a power density of 15.9 W/cm2 was used to treat intimal slices of extirpated human arterial atherosclerotic plaques. Peak signals derived from an ester bond of cholesterol ester decreased in height as irradiation time increased and disappeared completely after 180 seconds. No other change was observed in the infrared absorption spectrum after 180 seconds of irradiation, and no histological damage was noted. Conclusions The authors concluded that FEL irradiation can remove cholesterol ester selectively from human atheromatous CA plaques. This novel technique differs from previous approaches involving conventional lasers.

Ablation of Teflon Granuloma with the Free-Electron Laser Emitting in the Eight- to Nine-Micron Range

1998 ◽  
Vol 107 (4) ◽  
pp. 269-274 ◽  
Author(s):  
Grady Lee Bryant ◽  
Charles F. Lano ◽  
Lou Reinisch ◽  
Robert H. Ossoff ◽  
Jay A. Werkhaven
Keyword(s):  
Absorption Spectrum ◽  
Free Electron ◽  
Free Electron Laser ◽  
Infrared Absorption Spectrum ◽  
Infrared Region ◽  
Surrounding Tissue ◽  
Endoscopic Injection ◽  
Maximal Absorption ◽  
Teflon Granuloma ◽  
Laser Incision

In this study, we developed a rat model for Teflon granuloma and used this model to evaluate the removal of the granuloma at laser wavelengths at which Teflon has a maximal absorption. Twenty-four Teflon granulomas were created in 12 rats, and the gross and histologic effects from laser incision at four different wavelengths (8.25, 8.5, 8.75, and 10.6 Jim) were evaluated acutely and at 7 and 14 days postoperatively. Polytetrafluoroethylene, or Teflon, is a relatively inert substance that has been used over the past 4 decades for endoscopic injection into the thyroarytenoid muscle of the larynx for the purposes of laryngeal rehabilitation in cases of unilateral vocal fold paralysis or incomplete glottic closure. In certain cases in which formation of granulomatous reaction to the Teflon occurs, patients may have significant dysphonia or airway compromise. Once Teflon has infiltrated the surrounding tissue planes, it is exceedingly difficult to remove endoscopically. Endoscopic removal of this granuloma is usually attempted with the carbon dioxide (CO2) laser and has had limited success. Examination of the infrared absorption spectrum of polytetrafluoroethylene reveals strong absorption in the mid-infrared region in the 8- to 9-μm range, with minimal absorption at 10.6 μm. Therefore, this absorption spectrum predicts a more efficient vaporization of Teflon at wavelengths near 8.5 μm. Using the free-electron laser to generate 8.25-, 8.5-, and 8.75-μm laser light, we found Teflon granuloma ablation was far superior to CO2 laser ablation at 10.6 μm. The 8.25-, 8.5-, and 8.75-μm wavelengths selectively ablated Teflon granuloma with minimal to no collateral thermal injury to tissue. The differences in thermal effects observed while actually using the lasers were confirmed histologically.

scholarly journals Development of an Intravascular Laser Treatment with an Infrared Free Electron Laser

2004 ◽  
Vol 10 (1_suppl) ◽  
pp. 67-69 ◽  
Author(s):  
Y. Nakajima ◽  
K. Iwatsuki ◽  
K. Ishii ◽  
T. Fujinaka ◽  
K. Awazu ◽  
...  
Keyword(s):  
Absorption Spectrum ◽  
Fourier Transform ◽  
Free Electron ◽  
Free Electron Laser ◽  
Cholesterol Ester ◽  
Infrared Absorption Spectrum ◽  
Molecular Vibration ◽  
Carotid Plaques ◽  
Atherosclerotic Lesions ◽  
Tissue Damages

We have studied to develop an intravascular device with an infrared free electron laser (FEL) to treat occlusive carotid atherosclerotic lesions. In this study, we irradiated the FEL with a wavelength of 5.75 μm on surgical specimens of human atheromatous carotid plaques. After the irradiation on a cholesterol-ester-accumulated portion of the carotid plaques under proper conditions, a microscope transmission FTIR (Fourier Transform Infrared) spectroscopy showed that the peak of a tissue infrared absorption spectrum corresponding to the molecular vibration of cholesterol ester (5.75 μm) disappeared. Tissue damages associated with the irradiation were not histologically noted. This study demonstrated that irradiation of FEL can selectively remove cholesterol ester from the human atheromatous carotid plaques.

Effect of Chirality by the Free Electron Laser Irradiation

2010 ◽  
Vol 130 (2) ◽  
pp. 209-212 ◽  
Author(s):  
Daisuke Ishizuka ◽  
Keijiro Sakai ◽  
Nobuyuki Iwata ◽  
Hirofumi Yajima ◽  
Hiroshi Yamamoto
Keyword(s):  
Laser Irradiation ◽  
Free Electron ◽  
Free Electron Laser

Infrared absorption spectrum of vanadyl pentaammoniate

1971 ◽  
Vol 15 (4) ◽  
pp. 1349-1351
Author(s):  
L. V. Kobets ◽  
N. I. Vorob'ev ◽  
V. V. Pechkovskii ◽  
A. I. Komyak
Keyword(s):  
Absorption Spectrum ◽  
Infrared Absorption ◽  
Infrared Absorption Spectrum

The infrared absorption spectrum of 18O-labelled nitrobenzene

1964 ◽  
Vol 20 (2) ◽  
pp. 179-185 ◽  
Author(s):  
S. Pinchas ◽  
D. Samuel ◽  
B.L. Silver
Keyword(s):  
Absorption Spectrum ◽  
Infrared Absorption ◽  
Infrared Absorption Spectrum

Experimental study of Compton type free electron laser

1988 ◽  
Vol 65 (3) ◽  
pp. 573-577 ◽  
Author(s):  
FU ENSHENGf ◽  
WANG ZHIJIANG ◽  
WANG BING ◽  
CHEN LEI ◽  
SHI PEISHENG ◽  
...  
Keyword(s):  
Experimental Study ◽  
Free Electron ◽  
Free Electron Laser
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