Amplified photoelectrochemical immunoassay for the tumor marker carbohydrate antigen 724 based on dye sensitization of the semiconductor composite C3N4-MoS2

2018 ◽  
Vol 185 (12) ◽  
Author(s):  
Chuanmin Ding ◽  
Kaijing Song ◽  
Hongyun Meng ◽  
Bing Zhang ◽  
Zhihuan Zhao ◽  
...  
Keyword(s):  
Tumor Marker ◽  
Carbohydrate Antigen ◽  
Dye Sensitization ◽  
Photoelectrochemical Immunoassay

Carbohydrate Antigen 19-9 in Saliva

2011 ◽  
Vol 145 (5) ◽  
pp. 772-777 ◽  
Author(s):  
Gerhard Dyckhoff ◽  
Rolf Warta ◽  
Achim Gonnermann ◽  
Peter Karl Plinkert ◽  
Christa Flechtenmacher ◽  
...  
Keyword(s):  
Pilot Study ◽  
Tumor Marker ◽  
Tumor Markers ◽  
Malignant Tumors ◽  
Carbohydrate Antigen ◽  
Histopathological Diagnosis ◽  
Parotid Tumor ◽  
Parotid Saliva ◽  
Parotid Tumors ◽  
Serological Tumor

Objective. Facial nerve preservation and oncological safety are crucial in surgery of parotid tumors. An unexpected histopathologic diagnosis of a malignant parotid tumor, however, may unfavorably require a second, more radical surgery. The aim of this study was to find out whether the assessment of serological tumor markers in parotid saliva might have some diagnostic significance in the preoperative differentiation between benign and malignant parotid lesions. Study Design, Setting, Patients, and Methods. In a prospective pilot study performed at a university medical center in 28 patients with a unilateral parotid tumor, 7 serological tumor markers established in the clinical routine were quantitatively assessed in parotid saliva collected simultaneously on both sides after stimulation. The results were correlated with the histopathological diagnosis. Results. Of the 4 investigated tumors that were malignant neoplasms, 3 had a sufficient quantity of saliva available for tumor marker measurements. Carbohydrate antigen 19-9 (CA 19-9) consistently revealed high levels compared with the unaffected side in all malignant tumors, thus allowing malignant tumors to be differentiated from benign lesions. Conclusion. The results of this pilot study are encouraging, showing that preoperative tumor marker investigation in saliva from parotid glands is feasible and merits further investigation. CA 19-9 might be a valuable new diagnostic tool in the preoperative differentiation between malignant and benign parotid tumors and should be investigated in a larger number of patients.

LONG-TERM IMPACT OF A RESTRICTIVE LABORATORY TEST ORDERING FORM ON TUMOR MARKER PRESCRIPTIONS

2003 ◽  
Vol 19 (1) ◽  
pp. 106-113 ◽  
Author(s):  
Pierre Durieux ◽  
Philippe Ravaud ◽  
Raphaél Porcher ◽  
Yvonne Fulla ◽  
Catherine-Sophie Manet ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Tumor Marker ◽  
Laboratory Tests ◽  
Carbohydrate Antigen ◽  
Analysis Of Covariance ◽  
New Order ◽  
Order Form ◽  
Before And After ◽  
Long Term Impact

Objective: To evaluate the long-term impact of an intervention designed to reduce the ordering of three tumor markers frequently prescribed for gastroenterologic diseases (carcinoembryonic antigen, alpha-fetoprotein, carbohydrate antigen 19-9).Methods: A prospective study with time series analysis in a teaching hospital. Local clinical guidelines were developed and implemented through a new order form, designed as a reminder to the physician, restricting the ordering of laboratory tests. Ratios between the number of markers ordered and number of admissions were recorded during a 3-month period before and after intervention in the whole hospital and monthly on a 4-year period in two wards of the hospital (Department of Gastroenterology and Department of Internal Medicine). To evaluate the appropriateness of tumor marker orders, audits were performed on a sample of order forms, before and after (1 month and 2 years after) the implementation of the new order form.Results: The analysis of covariance showed a significant effect of the intervention in the hospital (p < .01), and in the Departments of Gastroenterology (p < .01) and Internal Medicine (p < .007). The decrease of tumor marker orders ranged from 25% (Internal Medicine Department) to 55% (whole hospital). A similar decrease was observed for the three studied markers. The appropriateness of prescriptions increased from 54.6% before to 73.6% after the implementation of the new order form, but decreased to 52.9% 2 years after intervention.Conclusions: Providing a reminder to clinicians through a specific order form represents an inexpensive and easy way to implement guidelines on use of laboratory tests.

scholarly journals Evaluation of serum carbohydrate antigen 19-9 as a diagnostic marker for pancreatic malignancy

2020 ◽  
Vol 7 (9) ◽  
pp. 2824
Author(s):  
A.K.M. Ahsan Ullah ◽  
S. M. Ferdous Ahmed ◽  
A. S. M. Lokman Hossain Chowdhury ◽  
Saad Mohammed ◽  
M. Mozammel Haque ◽  
...  
Keyword(s):  
Tumor Marker ◽  
Carbohydrate Antigen ◽  
Predictive Values ◽  
Benign Condition ◽  
Pancreatic Diseases ◽  
Pancreatic Malignancy ◽  
Serum Carbohydrate Antigen ◽  
High Level ◽  
Sensitivity Specificity ◽  
Medical University

Background: Carbohydrate antigen (CA) 19-9 is considered as a tumor marker in biliary-pancreatic malignancy. Though a high level may indicate the presence of a malignant disorder, it may rise even in benign condition. Similarly, the value may be normal even in malignant condition.Methods: An observational comparative study was conducted in the Department of Surgery of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from 01 June 2016 to 31 May 2017 to find out the sensitivity and specificity of CA 19-9 as a tumor marker in pancreatic malignancy in our perspective and to find out a cut-off value of CA 19-9 which might prove as a definitive indication of pancreatic malignancy.Results: The study shows when the cut off value of CA 19-9 is 37 U/ml. The sensitivity, specificity, positive and negative predictive values (PPV and NPV) were 77.8%, for all four characteristics respectively. But if the serum CA 19-9 threshold used to diagnose pancreatic cancer was raised to 100 and 120, sensitivity decreased to 72.2% and 66.7% and NPV decreased to 76.2% and 73.9% respectively. However, specificity increased to 88.9% and 94.4% and PPV increased to 86.7% and 92.3% respectively.Conclusions: Serum CA 19-9 level may be considered as an important determinant in the diagnosis of malignant pancreatic diseases and to assess the resectability of the lesions preoperatively, but other adjuncts are necessary in the overall management of pancreatic diseases.

scholarly journals Prognostic and Therapeutic Significance of Carbohydrate Antigen 19-9 as Tumor Marker in Patients with Pancreatic Cancer

Oncology ◽  
2006 ◽  
Vol 70 (4) ◽  
pp. 255-264 ◽  
Author(s):  
Stefan Boeck ◽  
Petra Stieber ◽  
Stefan Holdenrieder ◽  
Ralf Wilkowski ◽  
Volker Heinemann
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Marker ◽  
Carbohydrate Antigen

Phytic acid-based copper(ii) ion-selective electrode on graphene oxide for potentiometric immunoassay of breast cancer antigen 15-3

2019 ◽  
Vol 43 (28) ◽  
pp. 11171-11177 ◽  
Author(s):  
Min Zheng ◽  
Yong-Jin Cao ◽  
Wei-Hua Cai ◽  
Xi Shi ◽  
Mou-Feng Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Quantitative Determination ◽  
Tumor Marker ◽  
Phytic Acid ◽  
Carbohydrate Antigen ◽  
Ion Selective Electrode ◽  
Selective Electrode ◽  
Cancer Antigen

A potentiometric immunoassay based on a copper(ii) ion-selective electrode (Cu-ISE) was designed for the quantitative determination of carbohydrate antigen 15-3 (CA 15-3; a tumor marker associated with breast cancer).

scholarly journals Carbohydrate antigen 19-9 — tumor marker: Past, present, and future

2020 ◽  
Vol 12 (12) ◽  
pp. 468-490
Author(s):  
Tsinrong Lee ◽  
Thomas Zheng Jie Teng ◽  
Vishal G Shelat
Keyword(s):  
Tumor Marker ◽  
Carbohydrate Antigen
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