Ketogenic diet delays spinal fusion and decreases bone mass in posterolateral lumbar spinal fusion: an in vivo rat model

2018 ◽  
Vol 160 (10) ◽  
pp. 1909-1916 ◽  
Author(s):  
Qi Liu ◽  
Xiaomeng Wang ◽  
Zucheng Huang ◽  
Junhao Liu ◽  
Jianyang Ding ◽  
...  
Keyword(s):  
Bone Mass ◽  
Spinal Fusion ◽  
Ketogenic Diet ◽  
Rat Model ◽  
Lumbar Spinal Fusion ◽  
Lumbar Spinal

Effect of Lumbar Spinal Fusion on Adjacent Segment Discs—An In-Vivo Patient Study

2017 ◽  
Vol 17 (10) ◽  
pp. S117-S118
Author(s):  
Thomas D. Cha ◽  
Kamran Z. Khan ◽  
Yan Yu ◽  
Louis G. Jenis ◽  
James D. Kang ◽  
...  
Keyword(s):  
Spinal Fusion ◽  
Adjacent Segment ◽  
Lumbar Spinal Fusion ◽  
Patient Study ◽  
Lumbar Spinal

In Vivo Evaluation of a Resorbable Osteoinductive Composite as a Graft Substitute for Lumbar Spinal Fusion

1997 ◽  
Vol 10 (1) ◽  
pp. 1???11 ◽  
Author(s):  
Scott D. Boden ◽  
Jeffrey H. Schimandle ◽  
William C. Hutton ◽  
Christopher J. Damien ◽  
James J. Benedict ◽  
...  
Keyword(s):  
Spinal Fusion ◽  
Lumbar Spinal Fusion ◽  
In Vivo Evaluation ◽  
Lumbar Spinal

scholarly journals Comparing the Efficacy of Syngeneic Iliac and Femoral Allografts with Iliac Crest Autograft in a Rat Model of Lumbar Spinal Fusion

2020 ◽  
Author(s):  
Christina Holmes ◽  
Benjamin D. Elder ◽  
Wataru Ishida ◽  
Alexander Perdomo-Pantoja ◽  
John Locke ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Spinal Fusion ◽  
Rat Model ◽  
Iliac Crest ◽  
Bone Marrow Cells ◽  
Allograft Bone ◽  
Lumbar Spinal Fusion ◽  
Manual Palpation ◽  
Inbred Rat ◽  
Lumbar Spinal

Abstract Background: Despite widespread use of femoral-sourced allografts in clinical spinal fusion procedures and the increasing interest in using femoral reamer–irrigator–aspirator (RIA) autograft in clinical bone grafting, few studies have examined the efficacy of femoral grafts compared to iliac crest grafts in spinal fusion. The objective of this study was to directly compare the use of autologous iliac crest with syngeneic femoral and iliac allograft bone in the rat model of lumbar spinal fusion.Methods: Single-level bilateral posterolateral intertransverse process lumbar spinal fusion surgery was performed on Lewis rats divided into three experimental groups: iliac crest autograft; syngeneic iliac crest allograft; and syngeneic femoral allograft bone. Eight weeks postoperatively, fusion was evaluated via microCT analysis, manual palpation and histology. In vitro analysis of the colony-forming and osteogenic capacity of bone marrow cells derived from rat femurs and hips was also performed to determine whether there was a correlation with the fusion efficacy of these graft sources.Results: Although no differences were observed between groups in CT fusion mass volumes, iliac allografts displayed an increased number of radiographically fused fusion masses and a higher rate of bilateral fusion via manual palpation. Histologically, hip-derived grafts showed better integration with host bone than femur derived ones, likely associated with the higher concentration of osteogenic progenitor cells observed in hip-derived bone marrow. Conclusions: This study demonstrates the feasibility of using syngeneic allograft bone in place of autograft bone within inbred rat fusion models and highlights the need for further study of femoral-derived grafts in fusion.

scholarly journals The Influences of Different Ratios of Biphasic Calcium Phosphate and Collagen Augmentation on Posterior Lumbar Spinal Fusion in Rat Model

2017 ◽  
Vol 58 (2) ◽  
pp. 407 ◽  
Author(s):  
Kyung-Hyun Kim ◽  
Jeong-Yoon Park ◽  
Hyo-Suk Park ◽  
Keun-Su Kim ◽  
Dong-Kyu Chin ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Spinal Fusion ◽  
Rat Model ◽  
Biphasic Calcium Phosphate ◽  
Lumbar Spinal Fusion ◽  
Lumbar Spinal

In vivo evaluation of calcium sulfate as a bone graft substitute for lumbar spinal fusion

2001 ◽  
Vol 1 (6) ◽  
pp. 395-401 ◽  
Author(s):  
Paul A Glazer ◽  
Upshur M Spencer ◽  
Ron N Alkalay ◽  
Jeffrey Schwardt
Keyword(s):  
Bone Graft ◽  
Spinal Fusion ◽  
Calcium Sulfate ◽  
Bone Graft Substitute ◽  
Lumbar Spinal Fusion ◽  
In Vivo Evaluation ◽  
Lumbar Spinal

The effects of varenicline on lumbar spinal fusion in a rat model

2020 ◽  
Vol 20 (2) ◽  
pp. 300-306
Author(s):  
Jason R. Kang ◽  
Juliane D Glaeser ◽  
Brian Karamian ◽  
Linda Kanim ◽  
Zachary NaPier ◽  
...  
Keyword(s):  
Spinal Fusion ◽  
Rat Model ◽  
Lumbar Spinal Fusion ◽  
Lumbar Spinal

In Vivo Evaluation of Coralline Hydroxyapatite and Direct Current Electrical Stimulation in Lumbar Spinal Fusion

Spine ◽  
1999 ◽  
Vol 24 (20) ◽  
pp. 2127 ◽  
Author(s):  
Kevin J. Bozic ◽  
Paul A. Glazer ◽  
David Zurakowski ◽  
Bruce J. Simon ◽  
Stephen J. Lipson ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Spinal Fusion ◽  
Direct Current ◽  
Lumbar Spinal Fusion ◽  
In Vivo Evaluation ◽  
Coralline Hydroxyapatite ◽  
Lumbar Spinal

P143. Effects of 5-Lipoxygenase Inhibition on Posterolateral Lumbar Spinal Fusion in the Rat Model

2008 ◽  
Vol 8 (5) ◽  
pp. 169S-170S
Author(s):  
Colin Harris ◽  
Mitchell Reiter ◽  
J. Patrick O'Connor ◽  
Michael Vives ◽  
Michael Loeven ◽  
...  
Keyword(s):  
Spinal Fusion ◽  
Rat Model ◽  
Lumbar Spinal Fusion ◽  
Lipoxygenase Inhibition ◽  
Lumbar Spinal

scholarly journals Comparing the efficacy of syngeneic iliac and femoral allografts with iliac crest autograft in a rat model of lumbar spinal fusion

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Christina Holmes ◽  
Benjamin D. Elder ◽  
Wataru Ishida ◽  
Alexander Perdomo-Pantoja ◽  
John Locke ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Spinal Fusion ◽  
Rat Model ◽  
Iliac Crest ◽  
Bone Marrow Cells ◽  
Allograft Bone ◽  
Lumbar Spinal Fusion ◽  
Manual Palpation ◽  
Inbred Rat ◽  
Lumbar Spinal

Abstract Background Despite widespread use of femoral-sourced allografts in clinical spinal fusion procedures and the increasing interest in using femoral reamer–irrigator–aspirator (RIA) autograft in clinical bone grafting, few studies have examined the efficacy of femoral grafts compared to iliac crest grafts in spinal fusion. The objective of this study was to directly compare the use of autologous iliac crest with syngeneic femoral and iliac allograft bone in the rat model of lumbar spinal fusion. Methods Single-level bilateral posterolateral intertransverse process lumbar spinal fusion surgery was performed on Lewis rats divided into three experimental groups: iliac crest autograft, syngeneic iliac crest allograft, and syngeneic femoral allograft bone. Eight weeks postoperatively, fusion was evaluated via microCT analysis, manual palpation, and histology. In vitro analysis of the colony-forming and osteogenic capacity of bone marrow cells derived from rat femurs and hips was also performed to determine whether there was a correlation with the fusion efficacy of these graft sources. Results Although no differences were observed between groups in CT fusion mass volumes, iliac allografts displayed an increased number of radiographically fused fusion masses and a higher rate of bilateral fusion via manual palpation. Histologically, hip-derived grafts showed better integration with host bone than femur derived ones, likely associated with the higher concentration of osteogenic progenitor cells observed in hip-derived bone marrow. Conclusions This study demonstrates the feasibility of using syngeneic allograft bone in place of autograft bone within inbred rat fusion models and highlights the need for further study of femoral-derived grafts in fusion.

scholarly journals A poly(propylene glycol-co-fumaric acid) based bone graft extender for lumbar spinal fusion: in vivo assessment in a rabbit model

2005 ◽  
Vol 15 (6) ◽  
pp. 936-943 ◽  
Author(s):  
David D. Hile ◽  
Frank Kandziora ◽  
Kai-Uwe Lewandrowski ◽  
Stephen A. Doherty ◽  
Michael P. Kowaleski ◽  
...  
Keyword(s):  
Bone Graft ◽  
Spinal Fusion ◽  
Fumaric Acid ◽  
Rabbit Model ◽  
Lumbar Spinal Fusion ◽  
Lumbar Spinal ◽  
Bone Graft Extender ◽  
Poly Propylene ◽  
In Vivo Assessment
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