No association of serotonin transporter gene (SLC6A4) with schizophrenia and bipolar disorder in Japanese patients: association analysis based on linkage disequilibrium

2005 ◽  
Vol 113 (7) ◽  
pp. 899-905 ◽  
Author(s):  
M. Ikeda ◽  
N. Iwata ◽  
T. Suzuki ◽  
T. Kitajima ◽  
Y. Yamanouchi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Linkage Disequilibrium ◽  
Association Analysis ◽  
Serotonin Transporter ◽  
Japanese Patients ◽  
Serotonin Transporter Gene ◽  
Transporter Gene

A Pilot Study of Antidepressant-Induced Mania in Pediatric Bipolar Disorder: Characteristics, Risk Factors, and the Serotonin Transporter Gene

2006 ◽  
Vol 60 (9) ◽  
pp. 1005-1012 ◽  
Author(s):  
Fiona M. Baumer ◽  
Meghan Howe ◽  
Kim Gallelli ◽  
Diana Iorgova Simeonova ◽  
Joachim Hallmayer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bipolar Disorder ◽  
Pilot Study ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Pediatric Bipolar Disorder ◽  
Transporter Gene

Serotonin transporter linked promoter (polymorphism) in the serotonin transporter gene may be associated with antidepressant-induced mania in bipolar disorder

2006 ◽  
Vol 16 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Elisabet Masoliver ◽  
Ana Menoyo ◽  
Victor P??rez ◽  
Victor Volpini ◽  
Elisabet del Rio ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Serotonin Transporter ◽  
Promoter Polymorphism ◽  
Serotonin Transporter Gene ◽  
Transporter Gene

Serotonin transporter gene polymorphism and its association with bipolar disorder across different ethnic groups in Malaysia

2014 ◽  
Vol 55 ◽  
pp. S76-S81 ◽  
Author(s):  
Suriati Mohamed Saini ◽  
Nik Ruzyanei Nik Jaafar ◽  
Hatta Sidi ◽  
Marhani Midin ◽  
Azizah Mohd Radzi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Gene Polymorphism ◽  
Ethnic Groups ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene

Multimarkerhaplotypes within the serotonin transporter gene suggest evidence of an association with bipolar disorder

2000 ◽  
Vol 96 (6) ◽  
pp. 845-849 ◽  
Author(s):  
L. Mynett-Johnson ◽  
C. Kealey ◽  
E. Claffey ◽  
D. Curtis ◽  
L. Bouchier-Hayes ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene

Association study of a novel functional polymorphism of the serotonin transporter gene in bipolar disorder and suicidal behaviour

2005 ◽  
Vol 182 (1) ◽  
pp. 128-131 ◽  
Author(s):  
Vincenzo De Luca ◽  
Subi Tharmalingam ◽  
Nicole King ◽  
John Strauss ◽  
Natalie Bulgin ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Study ◽  
Serotonin Transporter ◽  
Suicidal Behaviour ◽  
Serotonin Transporter Gene ◽  
Functional Polymorphism ◽  
Transporter Gene

Bipolar disorder and the serotonin transporter gene: a family-based association study

1999 ◽  
Vol 29 (5) ◽  
pp. 1249-1254 ◽  
Author(s):  
G. KIROV ◽  
M. REES ◽  
I. JONES ◽  
F. MacCANDLESS ◽  
M. J. OWEN ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Serotonin Transporter ◽  
Promoter Region ◽  
Statistical Significance ◽  
Bipolar Affective Disorder ◽  
Serotonin Transporter Gene ◽  
Insertion Polymorphism ◽  
Transporter Gene ◽  
Case Control Studies ◽  
Intron 2

Background. The human serotonin transporter gene (5-HTT) is a strong candidate for involvement in the pathogenesis of mood disorders. Two common polymorphisms have been identified in the gene: a VNTR in intron 2 and a functional deletion/insertion in the promoter region. In previous studies we proposed that allele 12 of the VNTR might increase susceptibility for bipolar disorder.Methods. We have genotyped 122 parent–offspring trios of British Caucasian origin where the proband had DSM-IV Bipolar I disorder (BPI). The results were analysed with the transmission/disequilibrium test (TDT), which examines whether particular alleles are preferentially transmitted from heterozygous parents to affected offspring.Results. The 12 repeat in the VNTR in intron 2 was transmitted 72 times and not transmitted 56 times (χ2 = 2·0, 1 df, P=0·16). If we exclude 24 families in which the proband was a case in our published case–control studies (Collier et al. 1996a; Rees et al. 1997), the excess transmission of allele 12 reaches conventional levels of statistical significance: χ2 = 3·85, 1 df, P<0·05. The deletion/insertion polymorphism in the promoter region was not associated with BPI: 66 parents transmitted the inserted (L) allele and 59 parents transmitted the deleted (S) allele (χ2 = 0·39, 1 df, P=0·53).Conclusions. The 12 repeat of the VNTR in intron 2 of the serotonin transporter gene might be a susceptibility factor in bipolar affective disorder. The genetic effect, if true, is likely to be small, and requires confirmation in further studies using parental controls.

scholarly journals Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT)

1997 ◽  
Vol 2 (5) ◽  
pp. 398-402 ◽  
Author(s):  
M Rees ◽  
N Norton ◽  
I Jones ◽  
F McCandless ◽  
J Scourfield ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Serotonin Transporter ◽  
Association Studies ◽  
Serotonin Transporter Gene ◽  
Transporter Gene

scholarly journals Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings

2000 ◽  
Vol 5 (1) ◽  
pp. 91-95 ◽  
Author(s):  
D Hranilovic ◽  
S G Schwab ◽  
B Jernej ◽  
M Knapp ◽  
B Lerer ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene
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