Cholinergic dysfunction in subcortical ischaemic vascular dementia: a transcranial magnetic stimulation study

2008 ◽  
Vol 115 (5) ◽  
pp. 737-743 ◽  
Author(s):  
Raffaele Nardone ◽  
Jürgen Bergmann ◽  
Frediano Tezzon ◽  
Günther Ladurner ◽  
Stefan Golaszewski
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Vascular Dementia ◽  
Magnetic Stimulation ◽  
Cholinergic Dysfunction ◽  
Subcortical Ischaemic Vascular Dementia

scholarly journals Synergistic Effects of Mesenchymal Stem Cell Transplantation and Repetitive Transcranial Magnetic Stimulation on Promoting Autophagy and Synaptic Plasticity in Vascular Dementia

2018 ◽  
Vol 74 (9) ◽  
pp. 1341-1350 ◽  
Author(s):  
Fei Wang ◽  
Chi Zhang ◽  
Siyuan Hou ◽  
Xin Geng
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Vascular Dementia ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Synergistic Effects ◽  
Morris Water Maze Test ◽  
Control Group ◽  
Sham Operation ◽  
Therapeutic Effects ◽  
Mesenchymal Stem Cell Transplantation

Abstract Repetitive transcranial magnetic stimulation (rTMS) and mesenchymal stem cells (MSCs) transplantation both showed therapeutic effects on cognition impairment in vascular dementia (VD) model rats. However, whether these two therapies have synergistic effects and the molecular mechanisms remain unclear. In our present study, rats were randomly divided into six groups: control group, sham operation group, VD group, MSC group, rTMS group, and MSC+rTMS group. The VD model rats were prepared using a modified 2VO method. rTMS treatment was implemented at a frequency of 5 Hz, the stimulation intensity for 0.5 Tesla, 20 strings every day with 10 pulses per string and six treatment courses. The results of the Morris water maze test showed that the learning and memory abilities of the MSC group, rTMS group, and MSC+rTMS group were better than that of the VD group, and the MSC+rTMS group showed the most significant effect. The protein expression levels of brain-derived neurotrophic factor, NR1, LC3-II, and Beclin-1 were the highest and p62 protein was the lowest in the MSC+rTMS group. Our findings demonstrated that rTMS could further enhance the effect of MSC transplantation on VD rats and provided an important basis for the combined application of MSC transplantation and rTMS to treat VD or other neurological diseases.

scholarly journals Cholinergic dysfunction and amnesia in patients with Wernicke–Korsakoff syndrome: a transcranial magnetic stimulation study

2009 ◽  
Vol 117 (3) ◽  
pp. 385-391 ◽  
Author(s):  
Raffaele Nardone ◽  
Jürgen Bergmann ◽  
Pierpaolo De Blasi ◽  
Martin Kronbichler ◽  
Jörg Kraus ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Cholinergic Dysfunction ◽  
Korsakoff Syndrome

scholarly journals A Review of Transcranial Magnetic Stimulation in Vascular Dementia

2011 ◽  
Vol 31 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Giovanni Pennisi ◽  
Raffaele Ferri ◽  
Mariagiovanna Cantone ◽  
Giuseppe Lanza ◽  
Manuela Pennisi ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Vascular Dementia ◽  
Magnetic Stimulation

scholarly journals Evaluation of the Clinical Efficacy of Acupuncture and Moxibustion Combined with Repetitive Transcranial Magnetic Stimulation on Cognitive Function and Sleep Disorders in Patients with Mild Vascular Dementia

2021 ◽  
Vol 5 (5) ◽  
pp. 75-80
Author(s):  
Ningyao Wang ◽  
Guohui Xu ◽  
Nan Wang ◽  
Wuying Piao ◽  
Guanghui Gao
Keyword(s):  
Quality Of Life ◽  
Cognitive Function ◽  
Transcranial Magnetic Stimulation ◽  
Vascular Dementia ◽  
Magnetic Stimulation ◽  
Quality Score ◽  
Function Score ◽  
Life Score ◽  
Cognitive Function Score

Objective: To explore the clinical effects of acupuncture and repeated transcranial magnetic stimulation in patients with mild vascular dementia. Method: From May 2020 to May 2021, 40 patients with mild vascular dementia in Harbin Fourth Hospital (our hospital) were divided into the experimental group (20 cases, using conventional drugs + acupuncture + repeated transcranial magnetic stimulation) and the control group (20 cases, for example, the application of conventional medication). The improvement of cognitive function score, sleep quality score, quality of life score, and cerebral hemodynamics before and after treatment were compared between the two groups. Result: Before treatment, the difference in cognitive function score, sleep quality score, quality of life score, and cerebral hemodynamic index between the two groups of patients did not form, that is, p>0.05; after treatment, the experimental group’s cognitive function score was (19.45±2.47) points , Sleep quality score (12.18±2.09), quality of life score (33.29±4.08), left cerebral blood flow velocity (65.76±3.32) cm/s, right cerebral blood flow velocity (64.32±3.25) cm/s, more For the control group, P<0.05. Conclusion: In the clinical treatment of patients with mild vascular dementia, based on conventional drugs, combined with acupuncture and repetitive transcranial magnetic stimulation, the patients’ cognitive function can be improved, and the quality of sleep and quality of life can be improved. Comprehensive clinical promotion.

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