Glycoprotein G deletion mutants of equine herpesvirus 1 (EHV1; equine abortion virus) and EHV4 (equine rhinopneumonitis virus)

2005 ◽  
Vol 150 (12) ◽  
pp. 2583-2592 ◽  
Author(s):  
J. Huang ◽  
C. A. Hartley ◽  
N. P. Ficorilli ◽  
B. S. Crabb ◽  
M. J. Studdert
Keyword(s):  
Deletion Mutants ◽  
Equine Herpesvirus ◽  
Equine Herpesvirus 1 ◽  
Glycoprotein G ◽  
Herpesvirus 1 ◽  
Equine Abortion

scholarly journals CCL3 and Viral Chemokine-Binding Protein gG Modulate Pulmonary Inflammation and Virus Replication during Equine Herpesvirus 1 Infection

2007 ◽  
Vol 82 (4) ◽  
pp. 1714-1722 ◽  
Author(s):  
Gerlinde R. Van de Walle ◽  
Kaori Sakamoto ◽  
Nikolaus Osterrieder
Keyword(s):  
Pulmonary Inflammation ◽  
Body Weight Loss ◽  
Binding Activity ◽  
Immunomodulatory Activity ◽  
Equine Herpesvirus ◽  
Equine Herpesvirus 1 ◽  
Reduced Body ◽  
Glycoprotein G ◽  
Major Player ◽  
Herpesvirus 1

ABSTRACT CCL3 is a proinflammatory chemokine that mediates many of the cellular changes occurring in pulmonary disease. Here, CCL3−/− mice were used to investigate the role of this chemokine during respiratory herpesvirus infection. Compared to wild-type mice, CCL3−/− mice infected with the alphaherpesvirus equine herpesvirus 1 (EHV-1) displayed reduced body weight loss but had higher pulmonary viral loads. Lungs from infected CCL3−/− mice suffered a milder interstitial pneumonia, and fewer immune cells were recovered from the pulmonary airways after infection. We could also demonstrate that herpesvirus-encoded chemokine-binding glycoprotein G (gG) was capable of inhibiting the chemotactic functions of CCL3. This CCL3-mediated chemotaxis, however, was restored in the presence of gG-specific antibodies, which puts into question the advertised use of gG deletion mutants as marker vaccines. In summary, we concluded that CCL3 is a major player in controlling herpesvirus replication in the target organ, the lung, and does so by evoking a strong inflammatory response. The immunomodulatory activity of CCL3 is balanced by the expression of viral gG, whose chemokine-binding activity is mitigated in secondary infections by the production of anti-gG antibodies.

The highly O-glycosylated glycoprotein gp2 of equine herpesvirus 1 is encoded by gene 71.

1996 ◽  
Vol 70 (11) ◽  
pp. 8195-8198 ◽  
Author(s):  
J E Wellington ◽  
G P Allen ◽  
A A Gooley ◽  
D N Love ◽  
N H Packer ◽  
...  
Keyword(s):  
Equine Herpesvirus ◽  
Equine Herpesvirus 1 ◽  
Herpesvirus 1

scholarly journals Evaluation of the Variability of the ORF34, ORF68, and MLST Genes in EHV-1 from South Korea

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 425
Author(s):  
Hyung-Woo Kang ◽  
Eun-Yong Lee ◽  
Kyoung-Ki Lee ◽  
Mi-Kyeong Ko ◽  
Ji-Young Park ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
South Korea ◽  
Molecular Level ◽  
Economic Losses ◽  
Equine Herpesvirus ◽  
Equine Herpesvirus 1 ◽  
Mlst Analysis ◽  
Herpesvirus 1 ◽  
First Time ◽  
Group 1

Equine herpesvirus-1 (EHV-1) is an important pathogen in horses. It affects horses worldwide and causes substantial economic losses. In this study, for the first time, we characterized EHV-1 isolates from South Korea at the molecular level. We then aimed to determine the genetic divergences of these isolates by comparing them to sequences in databases. In total, 338 horse samples were collected, and 12 EHV-1 were isolated. We performed ORF30, ORF33, ORF68, and ORF34 genetic analysis and carried out multi-locus sequence typing (MLST) of 12 isolated EHV-1. All isolated viruses were confirmed as non-neuropathogenic type, showing N752 of ORF30 and highly conserved ORF33 (99.7–100%). Isolates were unclassified using ORF68 analysis because of a 118 bp deletion in nucleotide sequence 701–818. Seven EHV-1 isolates (16Q4, 19R166-1, 19R166-6, 19/10/15-2, 19/10/15-4, 19/10/18-2, 19/10/22-1) belonged to group 1, clade 10, based on ORF34 and MLST analysis. The remaining 5 EHV-1 isolates (15Q25-1, 15D59, 16Q5, 16Q40, 18D99) belonged to group 7, clade 6, based on ORF34 and MLST analysis.

Infection with Equine Herpesvirus 1 (EHV-1) Strain HVS25A in Pregnant Mice

1999 ◽  
Vol 120 (1) ◽  
pp. 15-27 ◽  
Author(s):  
C. Walker ◽  
V.M. Perotti ◽  
D.N. Love ◽  
J.M. Whalley
Keyword(s):  
Equine Herpesvirus ◽  
Equine Herpesvirus 1 ◽  
Pregnant Mice ◽  
Herpesvirus 1
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