Modeling trabecular bone adaptation to local bending load regulated by mechanosensing osteocytes

2014 ◽  
Vol 225 (10) ◽  
pp. 2833-2840 ◽  
Author(s):  
Yoshitaka Kameo ◽  
Taiji Adachi
Keyword(s):  
Trabecular Bone ◽  
Bone Adaptation ◽  
Bending Load

Effects of Local Bending Load on Trabecular Bone Adaptation

2018 ◽  
pp. 83-90
Author(s):  
Yoshitaka Kameo ◽  
Ken-ichi Tsubota ◽  
Taiji Adachi
Keyword(s):  
Trabecular Bone ◽  
Bone Adaptation ◽  
Bending Load

scholarly journals Mechano-Regulation of Trabecular Bone Adaptation Is Controlled by the Local in vivo Environment and Logarithmically Dependent on Loading Frequency

2020 ◽  
Vol 8 ◽  
Author(s):  
Ariane C. Scheuren ◽  
Paul Vallaster ◽  
Gisela A. Kuhn ◽  
Graeme R. Paul ◽  
Angad Malhotra ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Bone Adaptation ◽  
Loading Frequency

An Improved In Vivo Rat Tail Vertebra Model for the Study of Trabecular Bone Adaptation

1999 ◽  
Author(s):  
Mark J. Eichler ◽  
Chi Hyun Kim ◽  
X. Edward Guo
Keyword(s):  
Trabecular Bone ◽  
Large Scale ◽  
Bone Fractures ◽  
Mechanical Load ◽  
Bone Adaptation ◽  
Surgical Trauma ◽  
Micro Computed Tomography ◽  
Age Related ◽  
Rat Tail

Abstract The role of mechanical loading in trabecular bone adaptation is important for the understanding of bone integrity in different loading scenarios such as microgravity and for the etiology of age-related bone fractures. There have been numerous in vivo animal studies of bone adaptation, most of which are related to cortical bone remodeling, aimed at the investigation of Wolff’s Law [4], An interesting experimental model for trabecular bone adaptation has been developed in the rat tail vertebrae [2,3]. This model is attractive for trabecular bone adaptation studies because a controlled mechanical load can be applied to a whole vertebra with minimal surgical trauma, using a relatively inexpensive animal model. In addition, with advanced micro computed tomography (micro-CT) or micro magnetic resonance imaging (micro-MRI) coupled with large scale finite element modeling techniques, it is possible to characterize the three-dimensional (3D) stress/strain environment in the bone tissue close to a cellular level (∼25μm) [1]. Therefore, this in vivo rat tail model has a tremendous potential for quantification of the relationship between mechanical stimulation and biological response in trabecular bone adaptation.

scholarly journals A 3D trabecular bone homogenization technique

2020 ◽  
Vol 22 (3) ◽  
Author(s):  
Marco C. Marques ◽  
Jorge Belinha ◽  
António F. Oliveira ◽  
Maria Cristinha M. Cespedes ◽  
Renato M. Natal Jorge
Keyword(s):  
Mechanical Properties ◽  
Mechanical Behavior ◽  
Trabecular Bone ◽  
Multiple Scales ◽  
Bone Adaptation ◽  
Computationally Efficient ◽  
Micro Scale ◽  
Special Cases ◽  
Homogeneous Models ◽  
Time Required

Purpose: Bone is a hierarchical material that can be characterized from the microscale to macroscale. Multiscale models make it possible to study bone remodeling, inducing bone adaptation by using information of bone multiple scales. This work proposes a computationally efficient homogenization methodology useful for multiscale analysis. This technique is capable to define the homogenized microscale mechanical properties of the trabecular bone highly heterogeneous medium. Methods: In this work, a morphology - based fabric tensor and a set of anisotropic phenomenological laws for bone tissue was used, in order to define the bone micro-scale mechanical properties. To validate the developed methodology, several examples were performed in order to analyze its numerical behavior. Thus, trabecular bone and fabricated benchmarks patches (representing special cases of trabecular bone morphologies) were analyzed under compression. Results: The results show that the developed technique is robust and capable to provide a consistent material homogenization, indicating that the homogeneous models were capable to accurately reproduce the micro-scale patch mechanical behavior. Conclusions: The developed method has shown to be robust, computationally less demanding and enabling the authors to obtain close results when comparing the heterogeneous models with equivalent homogenized models. Therefore, it is capable to accurately predict the micro-scale patch mechanical behavior in a fraction of the time required by classic homogenization techniques.

scholarly journals Alteration of contraction-to-rest ratio to optimize trabecular bone adaptation induced by dynamic muscle stimulation

Bone ◽  
2011 ◽  
Vol 48 (2) ◽  
pp. 399-405 ◽  
Author(s):  
Hoyan Lam ◽  
Minyi Hu ◽  
Yi-Xian Qin
Keyword(s):  
Trabecular Bone ◽  
Bone Adaptation ◽  
Muscle Stimulation

scholarly journals Cortical and trabecular bone adaptation to incremental load magnitudes using the mouse tibial axial compression loading model

Bone ◽  
2013 ◽  
Vol 52 (1) ◽  
pp. 372-379 ◽  
Author(s):  
Alyssa M. Weatherholt ◽  
Robyn K. Fuchs ◽  
Stuart J. Warden
Keyword(s):  
Trabecular Bone ◽  
Axial Compression ◽  
Bone Adaptation ◽  
Compression Loading

Trabecular bone adaptation with an orthotropic material model

2002 ◽  
Vol 35 (2) ◽  
pp. 247-256 ◽  
Author(s):  
Zev Miller ◽  
Moshe B. Fuchs ◽  
Mircea Arcan
Keyword(s):  
Trabecular Bone ◽  
Orthotropic Material ◽  
Material Model ◽  
Bone Adaptation

The artiodactyl calcaneus as a potential ‘control bone’ cautions against simple interpretations of trabecular bone adaptation in the anthropoid femoral neck

2013 ◽  
Vol 64 (5) ◽  
pp. 366-379 ◽  
Author(s):  
Kristofer D. Sinclair ◽  
Ryan W. Farnsworth ◽  
Theresa X. Pham ◽  
Alex N. Knight ◽  
Roy D. Bloebaum ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Trabecular Bone ◽  
Bone Adaptation ◽  
Potential Control ◽  
Control Bone

scholarly journals TRABECULAR BONE ADAPTATION TO LOW-MAGNITUDE HIGH-FREQUENCY LOADING AT MICRO-GRAVITY

2012 ◽  
Vol 45 ◽  
pp. S531
Author(s):  
Antonia Torcasio ◽  
Katharina Jähn ◽  
Maarten Van Guyse ◽  
Pieter Spaepen ◽  
Andrea E. Tami ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
High Frequency ◽  
Bone Adaptation ◽  
Micro Gravity ◽  
Low Magnitude

The Clinical Biomechanics Award 2012 — Presented by the European Society of Biomechanics: Large scale simulations of trabecular bone adaptation to loading and treatment

2014 ◽  
Vol 29 (4) ◽  
pp. 355-362 ◽  
Author(s):  
Alina Levchuk ◽  
Alexander Zwahlen ◽  
Claudia Weigt ◽  
Floor M. Lambers ◽  
Sandro D. Badilatti ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
European Society ◽  
Large Scale ◽  
Bone Adaptation ◽  
Large Scale Simulations
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