Effects of different impact exercise modalities on bone mineral density in premenopausal women: a meta-analysis

2009 ◽  
Vol 28 (3) ◽  
pp. 251-267 ◽  
Author(s):  
Marrissa Martyn-St James ◽  
Sean Carroll
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Premenopausal Women ◽  
Mineral Density ◽  
Impact Exercise

scholarly journals Exercise and Bone Mineral Density in Premenopausal Women: A Meta-Analysis of Randomized Controlled Trials

2013 ◽  
Vol 2013 ◽  
pp. 1-16 ◽  
Author(s):  
George A. Kelley ◽  
Kristi S. Kelley ◽  
Wendy M. Kohrt
Keyword(s):  
Bone Mineral Density ◽  
Randomized Controlled Trials ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Premenopausal Women ◽  
The United States ◽  
Controlled Trials ◽  
Number Needed To Treat ◽  
Mineral Density ◽  
Randomized Controlled

Objective. Examine the effects of exercise on femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) in premenopausal women.Methods. Meta-analysis of randomized controlled exercise trials ≥24 weeks in premenopausal women. Standardized effect sizes (g) were calculated for each result and pooled using random-effects models,Zscore alpha values, 95% confidence intervals (CIs), and number needed to treat (NNT). Heterogeneity was examined usingQandI2. Moderator and predictor analyses using mixed-effects ANOVA and simple metaregression were conducted. Statistical significance was set atP≤0.05.Results. Statistically significant improvements were found for both FN (7g's, 466 participants,g=0.342, 95%  CI=0.132, 0.553,P=0.001,Q=10.8,P=0.22,I2=25.7%,NNT=5) and LS (6g's, 402 participants,g=0.201, 95%  CI=0.009, 0.394,P=0.04,Q=3.3,P=0.65,I2=0%,NNT=9) BMD. A trend for greater benefits in FN BMD was observed for studies published in countries other than the United States and for those who participated in home versus facility-based exercise. Statistically significant, or a trend for statistically significant, associations were observed for 7 different moderators and predictors, 6 for FN BMD and 1 for LS BMD.Conclusions. Exercise benefits FN and LS BMD in premenopausal women. The observed moderators and predictors deserve further investigation in well-designed randomized controlled trials.

scholarly journals Meta-analysis of genome-wide studies identifiesWNT16andESR1SNPs associated with bone mineral density in premenopausal women

2013 ◽  
Vol 28 (3) ◽  
pp. 547-558 ◽  
Author(s):  
Daniel L Koller ◽  
Hou-Feng Zheng ◽  
David Karasik ◽  
Laura Yerges-Armstrong ◽  
Ching-Ti Liu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Premenopausal Women ◽  
Mineral Density ◽  
Genome Wide

scholarly journals Comparative effectiveness of different exercises on bone mineral density in postmenopausal women: a systematic review and network meta-analysis of randomized controlled trials

2021 ◽  
Author(s):  
Yi Li ◽  
Xiaoyi Wang ◽  
Ruishi Zhang ◽  
Siyi Zhu ◽  
Liqiong Wang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Whole Body Vibration ◽  
Whole Body ◽  
Controlled Trials ◽  
Mineral Density ◽  
Randomized Controlled ◽  
Impact Exercise

Objective: To compare and rank different exercise interventions on bone mineral density (BMD) in postmenopausal women. Data Sources and Study Selection: MEDLINE, EMBASE, CINAHL, AMED, the Cochrane Central Register of Controlled Trials (CENTRAL), Scopus and Web of Science were searched from database inception to January 2021 of randomized controlled studies investigating the effect of exercise more than six months on BMD in postmenopausal women. Data Extraction and Synthesis: Data at baseline and post intervention (or the change from baseline) were extracted. A Bayesian random-effects network meta-analysis was performed. Main Outcomes and Measures: The primary outcome was the change of BMD (at lumbar spine, femoral neck, and total hip) from baseline values. Effect size measures were mean differences with 95% credible intervals (CrIs). Results: We identified 3324 citations and included 66 studies with a total number of 4336 participants. Associated with BMD at lumbar spine (LS) improve were found for multicomponent exercise, resistance training, mind body exercise, lower impact exercise, high impact exercise, and whole body vibration. With regard to femoral neck (FN), only multicomponent exercise, whole body vibration, and mind body exercise were effective. As for total hip (TH), only multicomponent exercise, resistance training, and flexibility exercise were found to be beneficial. Moreover, No matter the age of postmenopausal women, and the duration of intervention (range between 6 to 18 months), some certain kinds of exercise could be performed to improve BMD at LS and FN. Conclusions and Relevance: This NMA confirms that exercise therapy has clear benefits on bone mineral density in postmenopausal women. It also shows that the magnitude of effect varies depending on the outcome of interest, the age of participants, and the duration of intervention. Clinicians might consult the ranking of the exercise intervention presented in this study, when designating an optimal, individualized exercise prescription to improve BMD.

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