Decrease in serum leptin by troglitazone is associated with preventing bone loss in type 2 diabetic patients

2003 ◽  
Vol 21 (3) ◽  
pp. 166-171 ◽  
Author(s):  
Sumiyo Watanabe ◽  
Yasuhiro Takeuchi ◽  
Seiji Fukumoto ◽  
Hiroko Fujita ◽  
Tadasumi Nakano ◽  
...  
Metabolism ◽  
1999 ◽  
Vol 48 (10) ◽  
pp. 1290-1293 ◽  
Author(s):  
Bernd Fruehwald-Schultes ◽  
Werner Kern ◽  
Jürgen Beyer ◽  
Thomas Forst ◽  
Andreas Pfützner ◽  
...  

2016 ◽  
Vol 11 (3) ◽  
pp. 1-5
Author(s):  
Mainasara Sulaiman ◽  
Dahiru Gumel ◽  
Umar Usman ◽  
Anaja Ocheni ◽  
Yakubu Abdulmumini ◽  
...  

2011 ◽  
Vol 44 (13) ◽  
pp. S131
Author(s):  
Ghorban Mohammadzadeh ◽  
Nosratollah Zarghami

2021 ◽  
Vol 15 (6) ◽  
pp. 1459-1462
Author(s):  
A. Farooq ◽  
M. Riasat ◽  
H. K. N. Baloch ◽  
S. G. S. Shah ◽  
S. Shehzad ◽  
...  

Objective: To assess the association between the controlled and uncontrolled type-2 diabetic patients to the severity of Alveolar bone loss Study Designed: Cross-sectional analytical study. Place and Duration of Study: Department of Radiology, Sardar Begum Dental College and Khyber College of Dentistry Peshawar KPK from 1st October 2020 to 31st March 2021. Methodology: One hundred and seventy patients were included. Daniel formula (1999) was used for the patient to check the alveolar bone loss and questionnaire was filled by the researcher and examination was done on the dental unit using examination instruments. Results: The mean age was 39.41±6.92. The oral hygiene status in patients visiting the radiology department using toothpaste twice a day was 50.58% while bone loss among patient using toothpaste and brushing their teeth twice a day was 21.51%. The patient with a controlled glucose level was 41.28% while a patient with an uncontrolled glucose level was 58.72%. The bone loss in a patient with controlled HbA1c the bone loss in normal to moderate 38.38%while severe bone loss was 2.90% which is less as compared to the controlled group. The bone loss was reported higher in males (51.16%)as in females were 48.84%, but there was a severe bone loss in females 31,40% as compared to males 17.44%. Conclusion: There is a strong association between alveolar bone loss with the increased level of HbA1c. When the levels of HbA1c level increased the bone loss in both male and female was reported high. Type 2 diabetic patients having increased HbA1c levels cause severe bone loss. Keywords: Diabetes mellitus, Out-patient department, Hemoglobin A1c


Author(s):  
Sheikh Anwarul Karim ◽  
Samira Jamal ◽  
Sheikh Mahee Ridwan Raihan ◽  
Mohammad Alamgir Ahmed Chowdhury ◽  
Omar Faroque ◽  
...  

Objective: To evaluate the relationship of Serum Leptin and Early Nephropathy among uncontrolled type 2 Diabetes Mellitus patients of Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrinology and Metabolism (BIRDEM), Dhaka and Endocrinology department of Sylhet MAG Osmani Medical College (SOMC) & Hospital Sylhet, Bangladesh. Methods: This study was carried out from January 2013 to December 2015 among 100 type 2 diabetic patients from the outpatient department (OPD) BIRDEM and SOMC hospital. Results: 16 out of 30 controls and 65 out of 100 people with diabetes have a family history of diabetes. Early retinopathy and neuropathy were observed in 45.5% and 36.5% diabetic subjects. Mean±SD of serum urea in control subjects was 28.65±6.27; in diabetic subjects was 30.21±7.67. Serum creatinine in controls was 1.12±0.24, in diabetic subjects was 1.13±0.25. Serum leptin levels in control subjects {1.65 (0.05-8.66)} was lower than diabetic counterpart {1.21 (0.11-13.3)}. Leptin levels in male controls {(1.29 (0.05-2.49)} was significantly (P 0.000) lower than the female controls {4.03 (0.05-8.66)}. Conclusion: It was evident that there was very little or no association between serum leptin level and the indices of renal function. No changes of circulating serum Leptin concentration in the earlier stages of Diabetic Nephropathy were found.


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