Phosphonomethyl iminodiacetic acid-conjugated cobalt oxide nanoparticles liberate Co++ ion-induced stress associated activation of TNF-α/p38 MAPK/caspase 8-caspase 3 signaling in human leukemia cells

2014 ◽  
Vol 20 (1) ◽  
pp. 123-141 ◽  
Author(s):  
Sourav Chattopadhyay ◽  
Sandeep Kumar Dash ◽  
Satyajit Tripathy ◽  
Panchanan Pramanik ◽  
Somenath Roy
Keyword(s):  
Caspase 3 ◽  
Iminodiacetic Acid ◽  
Leukemia Cells ◽  
Caspase 8 ◽  
Oxide Nanoparticles ◽  
Human Leukemia ◽  
Cobalt Oxide Nanoparticles ◽  
Induced Stress ◽  
Human Leukemia Cells ◽  
Tnf Α

Cobalt oxide nanoparticles induced oxidative stress linked to activation of TNF-α/caspase-8/p38-MAPK signaling in human leukemia cells

2015 ◽  
Vol 35 (6) ◽  
pp. 603-613 ◽  
Author(s):  
Sourav Chattopadhyay ◽  
Sandeep Kumar Dash ◽  
Satyajit Tripathy ◽  
Balaram Das ◽  
Santanu Kar Mahapatra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cobalt Oxide ◽  
Mapk Signaling ◽  
Leukemia Cells ◽  
Caspase 8 ◽  
Oxide Nanoparticles ◽  
Human Leukemia ◽  
Cobalt Oxide Nanoparticles ◽  
Human Leukemia Cells ◽  
Tnf Α

Radiosensitizing Effect of Cerium Oxide Nanoparticles on Human Leukemia Cells

2018 ◽  
Vol 6 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Azadeh Montazeri ◽  
Zohreh Zal ◽  
Arash Ghasemi ◽  
Hooman Yazdannejat ◽  
Hossein Asgarian-Omran ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Leukemia Cells ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Human Leukemia ◽  
Radiosensitizing Effect ◽  
Human Leukemia Cells

Sulforaphane Induces Apoptosis of Acute Human Leukemia Cells Through Modulation of Bax, Bcl-2 and Caspase-3

2018 ◽  
Vol 14 (3) ◽  
pp. 369-376 ◽  
Author(s):  
Fanping Wang ◽  
Lulu Chen ◽  
Shanshan Zhu ◽  
Shanshan Wang ◽  
Chen Chen ◽  
...  
Keyword(s):  
Caspase 3 ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Human Leukemia Cells

Kaurene Diterpene Induces Apoptosis in Human Leukemia Cells Partly through a Caspase-8-Dependent Pathway

2004 ◽  
Vol 311 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Masuo Kondoh ◽  
Ikue Suzuki ◽  
Masao Sato ◽  
Fumihiro Nagashima ◽  
Siro Simizu ◽  
...  
Keyword(s):  
Leukemia Cells ◽  
Caspase 8 ◽  
Human Leukemia ◽  
Human Leukemia Cells ◽  
Dependent Pathway

scholarly journals Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity

2000 ◽  
Vol 32 (4) ◽  
pp. 197-203 ◽  
Author(s):  
Ho-Shik Kim ◽  
Seong-Yun Jeong ◽  
Jeong-Hwa Lee ◽  
Boe-Eun Kim ◽  
Jin Woo Kim ◽  
...  
Keyword(s):  
Caspase 3 ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Human Leukemia Cells ◽  
Induction Of Apoptosis

scholarly journals Kayeassamin a isolated from the flower of Mammea siamensis triggers apoptosis by activating caspase-3/-8 in hl-60 human leukemia cells

2016 ◽  
Vol 8 (4) ◽  
pp. 244 ◽  
Author(s):  
Yukihiro Shoyama ◽  
Takuhiro Uto ◽  
NguyenHuu Tung ◽  
Pinjutha Thongjankaew ◽  
Sorasak Lhieochaiphant
Keyword(s):  
Caspase 3 ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Human Leukemia Cells

Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure–Activity Relationships

2017 ◽  
Vol 45 (07) ◽  
pp. 1497-1511 ◽  
Author(s):  
Shinya Okubo ◽  
Takuhiro Uto ◽  
Aya Goto ◽  
Hiroyuki Tanaka ◽  
Tsuyoshi Nishioku ◽  
...  
Keyword(s):  
Cell Death ◽  
Dna Fragmentation ◽  
Antiproliferative Activity ◽  
Caspase 3 ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Leukemia Cells ◽  
Caspase 8 ◽  
Human Leukemia ◽  
Caspase 9

Berberine (BBR), an isoquinoline alkaloid, is a well-known bioactive compound contained in medicinal plants used in traditional and folk medicines. In this study, we investigated the subcellular localization and the apoptotic mechanisms of BBR were elucidated. First, we confirmed the incorporation of BBR into the cell visually. BBR showed antiproliferative activity and promptly localized to the nucleus from 5[Formula: see text]min to 15[Formula: see text]min after BBR treatment in HL-60 human promyelocytic leukemia cells. Next, we examined the antiproliferative activity of BBR (1) and its biosynthetically related compounds (2-7) in HL-60 cells. BBR exerted strongest antiproliferative activity among 1-7 and the results of structures and activity relation suggested that a methylenedioxyl group in ring A, an [Formula: see text]-alkyl group at C-9 position, and the frame of isoquinoline may be necessary for antiproliferative activity. Moreover, BBR showed the most potent antiproliferative activity in HL-60 cells among human cancer and normal cell lines tested. Next, we examined the effect of BBR on molecular events known as apoptosis induction. In HL-60 cells, BBR induced chromatin condensation and DNA fragmentation, and triggered the activation of PARP, caspase-3 and caspase-8 without the activation of caspase-9. BBR-induced DNA fragmentation was abolished by pretreatment with inhibitors against caspase-3 and caspase-8, but not against caspase-9. ERK and p38 were promptly phosphorylated after 15 min of BBR treatment, and this was correlated with time of localization to the nucleus of BBR. These results demonstrated that BBR translocated into nucleus immediately after treatments and induced apoptotic cell death by activation of caspase-3 and caspase-8.

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