Vanadate inhibition of protein tyrosine phosphatases in Jurkat cells: modulation by redox state

1999 ◽  
Vol 4 (3) ◽  
pp. 354-359 ◽  
Author(s):  
Cary Cuncic ◽  
Nancy Detich ◽  
Diane Ethier ◽  
Alan S. Tracey ◽  
Michael J. Gresser ◽  
...  
Keyword(s):  
Redox State ◽  
Protein Tyrosine Phosphatases ◽  
Jurkat Cells ◽  
Tyrosine Phosphatases ◽  
Protein Tyrosine ◽  
Vanadate Inhibition

A comprehensive review on the role of protein tyrosine phosphatases in gastric cancer development and progression

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Stefano Piatto Clerici ◽  
Patrícia Fernandes de Souza Oliveira ◽  
Erica Mie Akagi ◽  
Helon Guimarães Cordeiro ◽  
Jordana Maria Azevedo-Martins ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressors ◽  
Redox State ◽  
Molecular Mechanisms ◽  
Protein Tyrosine Phosphatases ◽  
Tyrosine Phosphatases ◽  
Protein Tyrosine ◽  
Molecular Aspects ◽  
H Pylori

Abstract The main post-translational reversible modulation of proteins is phosphorylation and dephosphorylation, catalyzed by protein kinases (PKs) and protein phosphatases (PPs) which is crucial for homeostasis. Imbalance in this crosstalk can be related to diseases, including cancer. Plenty of evidence indicates that protein tyrosine phosphatases (PTPs) can act as tumor suppressors and tumor promoters. In gastric cancer (GC), there is a lack of understanding of the molecular aspects behind the tumoral onset and progression. Here we describe several members of the PTP family related to gastric carcinogenesis. We discuss the associated molecular mechanisms which support the down or up modulation of different PTPs. We emphasize the Helicobacter pylori (H. pylori) virulence which is in part associated with the activation of PTP receptors. We also explore the involvement of intracellular redox state in response to H. pylori infection. In addition, some PTP members are under influence by genetic mutations, epigenetics mechanisms, and miRNA modulation. The understanding of multiple aspects of PTPs in GC may provide new targets and perspectives on drug development.

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