Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis.
In recent years, with the increase in Aurora kinase-related research, the important role of Aurora
kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new
target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application
of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represent
a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent
years, including studies of their biological function, their relationship with tumor progression, and
their inhibitors.
3D-QSAR and molecular docking analysis of (4-piperidinyl)-piperazines as acetyl-CoA carboxylases inhibitors