Effect of ortho- and para-chlorine substitution on hydroxychlorochalcone

2021 ◽  
Vol 27 (2) ◽  
Author(s):  
Rogério F. Costa ◽  
Antônio S. N. Aguiar ◽  
Igor D. Borges ◽  
Ricardo Ternavisk ◽  
Clodoaldo Valverde ◽  
...  
Keyword(s):  
Chlorine Substitution

The Chlorination of Di-tert-butyl-2-naphthol+

1984 ◽  
Vol 39 (10) ◽  
pp. 1427-1432
Author(s):  
Edgar Streich ◽  
Anton Rieker
Keyword(s):  
Nmr Spectroscopy ◽  
Tert Butyl ◽  
Chlorine Substitution ◽  
C Nmr

Chlorination of the di-tert-butylation product of 2-naphthol leads to 3,6-di-tert-butyl-1,1-dichloro- l,2-dihydronaphthalen-2-one (4a) instead of 1,6-di-tert-butyl-1,3-dichloro-1,2-dihydronaphthalen-2-one (2) as reported [2], The structural proof was mainly offered by 13C NMR spectroscopy. The influence of annelation and chlorine substitution in 1,2-dihydronaphthalen-2-ones on δ13c=o is discussed, which is of importance for the use of δ13c=o for a general discrimination between ortho- and para-quinolide structures.

Antimony-121 nuclear magnetic resonance study of hexahaloantimonate anions

1981 ◽  
Vol 59 (20) ◽  
pp. 2940-2949 ◽  
Author(s):  
R. Garth Kidd ◽  
H. Garth Spinney
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Nmr Spectra ◽  
Central Atom ◽  
Chemical Shifts ◽  
Nuclear Magnetic Resonance Study ◽  
Acetonitrile Solution ◽  
Trans Isomers ◽  
Magnetic Resonance Study ◽  
Chlorine Substitution ◽  
Nuclear Shielding

The seven hexahaloantimonate anions in the series [SbClnBr6−n]− have been prepared and their antimony-121 nmr spectra show that for [SbCl4Br2]−, [SbCl3Br3]−, and [SbCl2Br4]−, only the cis isomers are present in acetonitrile solution. The pairwise additivity model for central atom shielding has been used for configuration assignments. Models relevant to the higher incidence of cis over trans isomers are discussed. The nuclear shielding of 121Sb is the most sensitive to halogen substitution of all the elements whose halide chemical shifts have been studied. Antimony shieldings exhibit normal halogen dependence, with bromine substitution causing upfield shifts relative to chlorine substitution.

Dibenzo[ b , f ][1,4]oxazepines and dibenzo[ b , e ]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H 1 R, H 4 R, 5-HT 2A R and other selected GPCRs

2016 ◽  
Vol 113 ◽  
pp. 610-625 ◽  
Author(s):  
Franziska Naporra ◽  
Susanne Gobleder ◽  
Hans-Joachim Wittmann ◽  
Julia Spindler ◽  
Michael Bodensteiner ◽  
...  
Keyword(s):  
Substitution Pattern ◽  
Chlorine Substitution

scholarly journals Curcumin-based pyrazoline analogues as selective inhibitors of human monoamine oxidase A

MedChemComm ◽  
2018 ◽  
Vol 9 (7) ◽  
pp. 1164-1171 ◽  
Author(s):  
Chandrani Nath ◽  
Vishnu Nayak Badavath ◽  
Abhishek Thakur ◽  
Gulberk Ucar ◽  
Orlando Acevedo ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Selective Inhibition ◽  
Monoamine Oxidase A ◽  
Selective Inhibitors ◽  
Chlorine Substitution ◽  
Pyrazoline Derivative

Chlorine substitution on a 3,5-diphenyl-pyrazoline derivative enabled potent and selective inhibition of hMAO-A; calculations suggest an “aromatic sandwich” orientation is responsible.

Sign in / Sign up

Export Citation Format

Share Document