pyrazoline derivative
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2022 ◽  
Vol 1251 ◽  
pp. 132063
P. Akhileshwari ◽  
K. Sharanya ◽  
Hamdi Hamid Sallam ◽  
M.A. Sridhar ◽  
N.K. Lokanath

Saras Kumar Jain ◽  
Rohit Singhal ◽  
Neetesh K. Jain

Pyrazoline is dihydropyrazole having only one endocyclic double bond. Synthesis of pyrazoline derivatives from chalcones is an active arena of investigation due to established pharmacological result. In present study, chalcones were prepared by reacting of acetophenone with benzaldehyde. Then prepared chalcones react with isoniazid in the presence of glacial acetic acid results pyrazoline derivative. Physical parameters such as color, crystal structure, solubility, melting point, retardation factor (Rf) and % yield was evaluated. Confirmations of structures of all synthesized derivatives, were done by spectroscopic data of IR, 1HNMR and Mass spectroscopy. Also, all synthesized compounds were evaluated for antibacterial activity against B. subtilis, S. aureus, P.aeruginosa and E.coli, and antifungal activity was accomplished against C. albicans and A. niger at the different conc. and concluded that some compounds have excellent antimicrobial activity and most of the synthesized compounds exhibits moderate antimicrobial activity.

Anupam Sharma ◽  
Alok Pal Jain ◽  
Mayank Gangwar

The goal of this study was to develop, synthesise, and characterise a novel 1,3,5-trisubstituted-2-pyrazoline derivative, as well as test its antibacterial activity. The reaction of chalcone derivatives with succinic hydrazide in the presence of pyridine yielded the 1,3,5-tri-substituted-2-pyrazolines derivatives. The IR, 1HNMR, and mass spectral analyses were used to characterise a total of 20 substances. Antibacterial activity of the compounds was tested on five Gm+Ve bacterial strains (Staphylococcus aureus, S. Faecalis, Bacillus Substilis, P. Vulgaris, and B. Pumilus) and two Gm-Ve bacterial strains (Staphylococcus aureus, S. Faecalis, Bacillus Substilis, P. Vulgaris, and B. Pumilus) and two Gm-Ve i.e. Escherichia Coli, Klebsiella Penumoniae in two different concentration i.e. 50 and 100 µg/ml by Agar-diffusion method using Cup-plate method. Standard antimicrobial drugs were Norfloxacin and Ciprofloxacin. The antibacterial activity of substances against Gm+Ve bacterial strains (Staphylococcus Aureus, Staphylococcus Faecalis, Bacillus Substilis, Pseudomonas Vulgaris, and B. Pumilus) suggested the following order of action: BR-3 >BR-2>BR-1>CL-4>BR-4>CL-3> CL-2>CL-5>CL-6>ME-3>ME-2>ME-4>ME-5>ME-6>ME-7>CL-7>CL-8>CL-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME The chemicals of the BR-1 to BR-4 series have the most action. ME-8, CL-8, CL-7, CL-1, ME-5, ME-6, and ME-1 have light activity, whereas CL-2, CL-5, ME-4, CL-6, ME-3, ME-2, and ME-7 have moderate activity. The compounds BR-3, BR-2, BR-1, CL-4, BR-4, and CL-3 have been shown to have excellent action. The result data of antibacterial activity suggested that Cl, Br, F, and Nitro substitution at third and Fifth position may enhance the antbacterial activity of the compounds but the methyl and methoxy substitution may resulted in reduction of the activity.

2021 ◽  
Vol 32 (3) ◽  
pp. 8
Mohammed Ibrahim Sultan ◽  
Ahmed M. Abdula ◽  
Rana I. Faeq ◽  
Mahdi F. Radi

A new series of pyrazoline derivatives (3-10) have been synthesized and characterized on the basis of FT-IR, 1H-NMR, and Mass techniques. 1-(4-Aminophenyl)-3-(pyridin-4-yl)prop-2-en-1-one (1) as a starting material was prepared by the reaction of 4-aminoacetophenone and 4-pyridinecarboxaldehyde in ethanol, using sodium hydroxide as a catalyst. Pyrazoline derivatives 2 was obtained via the cyclization reaction of compound 1 by the action of hydrazine hydrate 80% in ethanol. The target derivatives (3-8) were obtained by the reaction of pyrazoline derivative (2) with the corresponding aldehyde in ethanol. The novel pyrazoline derivatives 9 and 10 were synthesized by the reaction of pyrazoline derivative 2 with the corresponding anhydride (maleic or phthalic anhydride) in presence of anhydrous sodium acetate in glacial acetic acid. The synthesized derivatives were screened against several bacterial strains: Staphylococcus aureus, Staphylococcus espidermididis, Escherichia coli, Klebsiella and Candida albicans. The synthesized compounds showed promising bio-activity compared with amoxicillin.

2021 ◽  
Vol 1227 ◽  
pp. 129667
Salman A. Khan ◽  
Qasim Ullah ◽  
Salahuddin Syed ◽  
Alimuddin ◽  
Abdulraheem S.A. Almalki ◽  

CrystEngComm ◽  
2021 ◽  
Vol 23 (1) ◽  
pp. 221-226
Shengmei Guo ◽  
Yuyang Zhang ◽  
Jianyan Huang ◽  
Lin Kong ◽  
Jiaxiang Yang

High dual-state blue emission of a functionalized pyrazoline derivative for picric acid detection.

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