Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D.

Neurogenetics ◽  
1998 ◽  
Vol 1 (3) ◽  
pp. 223-228 ◽  
Author(s):  
M. B. Graeber ◽  
S. Kösel ◽  
E. Grasbon-Frodl ◽  
H. J. Möller ◽  
P. Mehraein
Keyword(s):  
Alzheimer Disease ◽  
Disease Patient ◽  
Apoe Genotype ◽  
Alzheimer Disease Patient

Takotsubo Cardiomyopathy in an Alzheimer Disease Patient

2020 ◽  
Vol 34 (4) ◽  
pp. 360-361 ◽  
Author(s):  
Stephanie R.A. Moulin Mares ◽  
Jaqueline S. Groner ◽  
Melissa P. de Oliveira ◽  
Ludmilla V. Lírio ◽  
Paulo C. Coutinho ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Takotsubo Cardiomyopathy ◽  
Disease Patient ◽  
Alzheimer Disease Patient

scholarly journals Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

2020 ◽  
Vol 15 (1) ◽  
pp. 256-273
Author(s):  
Yuriy Pomeshchik ◽  
Oxana Klementieva ◽  
Jeovanis Gil ◽  
Isak Martinsson ◽  
Marita Grønning Hansen ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Disease Patient ◽  
Patient Specific ◽  
Alzheimer Disease Patient ◽  
Innovative Tool ◽  
Cellular Phenotypes ◽  
Human Ipsc

scholarly journals Human iPSC-derived hippocampal spheroids: An innovative tool for stratifying Alzheimer disease patient-specific cellular phenotypes and developing therapies

2021 ◽  
Vol 16 (11) ◽  
pp. 2838
Author(s):  
Yuriy Pomeshchik ◽  
Oxana Klementieva ◽  
Jeovanis Gil ◽  
Isak Martinsson ◽  
Marita Grønning Hansen ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Disease Patient ◽  
Patient Specific ◽  
Alzheimer Disease Patient ◽  
Innovative Tool ◽  
Cellular Phenotypes ◽  
Human Ipsc

Brain 18F-Florbetapir PET/CT Findings in an Early-onset Alzheimer Disease Patient Carrying Presenilin-1 G378E Mutation

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Angelina Cistaro ◽  
Natale Quartuccio ◽  
Laura Cassalia ◽  
Daniela Vai ◽  
Ugo Paolo Guerra ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Early Onset ◽  
Disease Patient ◽  
Presenilin 1 ◽  
Alzheimer Disease Patient ◽  
Ct Findings ◽  
Pet Ct

scholarly journals Lipoic Acid and N-acetyl Cysteine Decrease Mitochondrial-Related Oxidative Stress in Alzheimer Disease Patient Fibroblasts

2007 ◽  
Vol 12 (2) ◽  
pp. 195-206 ◽  
Author(s):  
Paula I. Moreira ◽  
Peggy L.R. Harris ◽  
Xiongwei Zhu ◽  
Maria S. Santos ◽  
Catarina R. Oliveira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer Disease ◽  
Lipoic Acid ◽  
Disease Patient ◽  
Alzheimer Disease Patient ◽  
Acetyl Cysteine

scholarly journals Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease

2012 ◽  
Vol 14 (8) ◽  
pp. 742-748 ◽  
Author(s):  
J. Scott Roberts ◽  
◽  
Clara A. Chen ◽  
Wendy R. Uhlmann ◽  
Robert C. Green
Keyword(s):  
Alzheimer Disease ◽  
Apoe Genotype ◽  
Risk Education

Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease

Neurology ◽  
2004 ◽  
Vol 62 (11) ◽  
pp. 1977-1983 ◽  
Author(s):  
P. Tiraboschi ◽  
L. A. Hansen ◽  
E. Masliah ◽  
M. Alford ◽  
L. J. Thal ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Apoe Genotype

scholarly journals Blood and Brain Transcriptome Analysis Reveals APOE Genotype-mediated and Immune-related Pathways Involved in Alzheimer Disease

2021 ◽  
Author(s):  
Rebecca Panitch ◽  
Junming Hu ◽  
Weiming Xia ◽  
David A Bennett ◽  
Thor D Stein ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Blood Brain Barrier ◽  
Vascular Injury ◽  
Apoe Genotype ◽  
Enrichment Analysis ◽  
Gene Set Enrichment Analysis ◽  
Differentially Expressed ◽  
Brain Barrier ◽  
Gene Set Enrichment ◽  
Gene Set

Abstract Background: While Alzheimer disease (AD) is generally considered as a brain disorder, blood biomarkers may be useful for diagnosis and prediction of AD brain pathology. The APOE ε4 allele has shown cerebrovascular effects including acceleration of blood brain barrier breakdown. Methods: We evaluated differential expression of previously established AD genes in brains from 344 pathologically confirmed AD cases and 232 controls and in blood from 112 pathologically confirmed AD cases and 67 controls from the Religious Orders Study and Memory and Aging Project. Differential gene expression between AD cases and controls was analyzed in the blood and brain jointly using a multivariate approach in the total sample and within APOE genotype groups. Gene set enrichment analysis was performed within APOE genotype groups using the results from the combined blood and brain analyses to identify biologically important pathways. Gene co-expression networks in brain and blood samples were investigated using weighted correlation network analysis. Top ranked genes from networks and pathways were further evaluated with vascular injury traits. Results: We observed differentially expressed genes with P<0.05 in both brain and blood for established AD genes INPP5D (upregulated) and HLA-DQA1 (downregulated). PIGHP1 and FRAS1 were differentially expressed at the transcriptome-wide level (P<3.3x10 -6 ) within ε2/ε3 and ε3/ε4 groups, respectively. Gene-set enrichment analysis revealed 21 significant pathways (false discovery rate P<0.05) in at least one APOE genotype group. Ten pathways were significantly enriched in the ε3/ε4 group, and six of these were unique to these subjects. Four pathways were enriched for AD upregulated genes in the ε3/ε4 group and AD downregulated genes in ε4 lacking subjects. We identified a co-expressed gene network in brain that reproduced in blood and showed higher average expression in ε4 carriers. Twenty-three genes from pathway and network analyses were significantly associated at P<0.05 with at least one vascular injury trait. Conclusion: These results suggest that APOE genotype contributes to unique expression network profiles in both blood and brain. Several genes in these networks are associated with measures of vascular injury and potentially contribute to ε4’s effect on the blood brain barrier.

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