scholarly journals Human iPSC-derived hippocampal spheroids: An innovative tool for stratifying Alzheimer disease patient-specific cellular phenotypes and developing therapies

2021 ◽  
Vol 16 (11) ◽  
pp. 2838
Author(s):  
Yuriy Pomeshchik ◽  
Oxana Klementieva ◽  
Jeovanis Gil ◽  
Isak Martinsson ◽  
Marita Grønning Hansen ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Disease Patient ◽  
Patient Specific ◽  
Alzheimer Disease Patient ◽  
Innovative Tool ◽  
Cellular Phenotypes ◽  
Human Ipsc

scholarly journals Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

2020 ◽  
Vol 15 (1) ◽  
pp. 256-273
Author(s):  
Yuriy Pomeshchik ◽  
Oxana Klementieva ◽  
Jeovanis Gil ◽  
Isak Martinsson ◽  
Marita Grønning Hansen ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Disease Patient ◽  
Patient Specific ◽  
Alzheimer Disease Patient ◽  
Innovative Tool ◽  
Cellular Phenotypes ◽  
Human Ipsc

Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D.

Neurogenetics ◽  
1998 ◽  
Vol 1 (3) ◽  
pp. 223-228 ◽  
Author(s):  
M. B. Graeber ◽  
S. Kösel ◽  
E. Grasbon-Frodl ◽  
H. J. Möller ◽  
P. Mehraein
Keyword(s):  
Alzheimer Disease ◽  
Disease Patient ◽  
Apoe Genotype ◽  
Alzheimer Disease Patient

Takotsubo Cardiomyopathy in an Alzheimer Disease Patient

2020 ◽  
Vol 34 (4) ◽  
pp. 360-361 ◽  
Author(s):  
Stephanie R.A. Moulin Mares ◽  
Jaqueline S. Groner ◽  
Melissa P. de Oliveira ◽  
Ludmilla V. Lírio ◽  
Paulo C. Coutinho ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Takotsubo Cardiomyopathy ◽  
Disease Patient ◽  
Alzheimer Disease Patient

Brain 18F-Florbetapir PET/CT Findings in an Early-onset Alzheimer Disease Patient Carrying Presenilin-1 G378E Mutation

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Angelina Cistaro ◽  
Natale Quartuccio ◽  
Laura Cassalia ◽  
Daniela Vai ◽  
Ugo Paolo Guerra ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Early Onset ◽  
Disease Patient ◽  
Presenilin 1 ◽  
Alzheimer Disease Patient ◽  
Ct Findings ◽  
Pet Ct

scholarly journals Lipoic Acid and N-acetyl Cysteine Decrease Mitochondrial-Related Oxidative Stress in Alzheimer Disease Patient Fibroblasts

2007 ◽  
Vol 12 (2) ◽  
pp. 195-206 ◽  
Author(s):  
Paula I. Moreira ◽  
Peggy L.R. Harris ◽  
Xiongwei Zhu ◽  
Maria S. Santos ◽  
Catarina R. Oliveira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer Disease ◽  
Lipoic Acid ◽  
Disease Patient ◽  
Alzheimer Disease Patient ◽  
Acetyl Cysteine

scholarly journals SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
Peiyee Lee ◽  
Nathan T. Martin ◽  
Kotoka Nakamura ◽  
Soheila Azghadi ◽  
Mandana Amiri ◽  
...  
Keyword(s):  
Ataxia Telangiectasia ◽  
Patient Specific ◽  
Cellular Phenotypes ◽  
Derivatives Of

scholarly journals Patient-specific computational haemodynamics associated with surgical creation of an arteriovenous fistula

2021 ◽  
Author(s):  
George Hyde-Linaker ◽  
Pauline Hall Barrientos ◽  
Sokratis Stoumpos ◽  
Asimina Kazakidi
Keyword(s):  
Blood Flow ◽  
Flow Rate ◽  
Disease Patient ◽  
Blood Flow Rate ◽  
Fold Increase ◽  
Transitional Flow ◽  
Patient Specific ◽  
Venous Anastomosis ◽  
End Stage

Abstract Despite arteriovenous fistulae (AVF) being the preferred vascular access for haemodialysis, high primary failure rates (30-70%) and low one-year patency rates (40-70%) hamper their use. The haemodynamics within the vessels of the fistula change significantly following surgical creation of the anastomosis and can be a surrogate of AVF success or failure. Computational fluid dynamics (CFD) can crucially predict AVF outcomes through robust analysis of a fistula’s haemodynamic patterns, which is impractical in-vivo. We present a proof-of-concept CFD framework for characterising the AVF blood flow prior and following surgical creation of a successful left radiocephalic AVF in a 20-year-old end-stage kidney disease patient. The reconstructed vasculature was generated utilising multiple contrast-enhanced magnetic resonance imaging (MRI) datasets. Large eddy simulations were conducted for establishing the extent of arterial and venous remodelling. Following anastomosis creation, a significant 2-3-fold increase in blood flow rate was induced downstream of the left subclavian artery. This was validated through comparison with post-AVF patient-specific phase-contrast data. The increased flow rate yielded an increase in time-averaged wall shear stress (TAWSS), a key marker of adaptive vascular remodelling. We have demonstrated TAWSS and oscillatory shear distributions of the transitional-flow in the venous anastomosis are predictive of AVF remodelling.

scholarly journals Variation in end-stage renal disease patient outcomes: what we know, what should we know, and how do we find it out?

1993 ◽  
Vol 3 (11) ◽  
pp. 1738-1747
Author(s):  
P Kurtin ◽  
A R Nissenson
Keyword(s):  
Patient Outcomes ◽  
Outcome Measure ◽  
Disease Patient ◽  
Patient Specific ◽  
Quality Cost ◽  
Current State ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

The size and expense of the ESRD program exceed all predictions made when the program was first initiated. Although the effectiveness of dialytic therapy is unquestioned, its value (quality/cost) is actively debated in this era of constricting resources. To better evaluate the quality of the ESRD program, it is essential to first define and quantitate the outcomes of dialytic care. Although mortality is a convenient outcome measure, it may be affected by many patient-specific as well as other factors that must be considered when evaluating and comparing new and existing technologies or advances. Quality of life is only beginning to be used in depth as an outcome measure, and much work is needed to standardize research methodology and thus move this area forward. The following review describes the current state of knowledge regarding outcomes of ESRD patients and proposes areas for future investigation, which should help increase the understanding of the value of the ESRD program to patients, providers, and payors.

Abstract 378: Evaluation of Patient Specific MTERF4 Variants in Gene Edited Human iPSC-derived Cardiomyocytes

2018 ◽  
Vol 123 (Suppl_1) ◽  
Author(s):  
Maribel Marquez ◽  
Chris McDermott-Roe ◽  
Mike Grzybowski ◽  
Daniel Helbling ◽  
David P Dimmock ◽  
...  
Keyword(s):  
Patient Specific ◽  
Human Ipsc
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