Varicella zoster virus meningoencephalitis accompanied by sporadic skin lesions in an older immunocompetent adult

2007 ◽  
Vol 13 (4) ◽  
pp. 270-272 ◽  
Author(s):  
Kota Sugisaki ◽  
Hiroaki Yoshida
Keyword(s):  
Varicella Zoster Virus ◽  
Skin Lesions ◽  
Immunocompetent Adult ◽  
Varicella Zoster

scholarly journals Varicella Zoster Virus-Associated Meningitis as a Rebound Varicella Zoster Disease after Antiviral Discontinuation

2021 ◽  
pp. 148-153
Author(s):  
Tetsuko Sato ◽  
Takenobu Yamamoto ◽  
Yumi Aoyama
Keyword(s):  
Herpes Zoster ◽  
Early Diagnosis ◽  
Varicella Zoster Virus ◽  
Immunosuppressive Therapy ◽  
Unusual Case ◽  
Cranial Nerves ◽  
Skin Lesions ◽  
Immunocompromised Patients ◽  
Aggressive Treatment ◽  
Varicella Zoster

Varicella zoster virus (VZV)-associated meningitis is usually progressive and can be fatal, and early diagnosis and aggressive treatment with intravenous antivirals such as acyclovir (ACV) are required in immunocompromised patients. Patients receiving corticosteroids and immunosuppressive therapy have a significantly higher risk of VZV-associated meningitis. In this report, we describe an unusual case of herpes zoster (HZ) in a young woman who was first diagnosed during tapering of prednisone for dermatomyositis. The skin lesions affected the left L2 and L3 dermatomes, which is unusual in VZV-associated meningitis. Despite showing a good rapid response to antivirals, she developed VZV-associated meningitis immediately after discontinuation of ACV. This phenomenon is often called rebound VZV reactivation disease and occurs after discontinuation of antivirals. This case was notable in that the affected dermatomes were distant from the cranial nerves. Thus, progression of HZ to VZV reactivation-associated meningitis can occur even in appropriately treated HZ patients. Continuation of antivirals beyond 1 week in patients on immunosuppressive therapy may be associated with a decreased risk of severe rebound VZV disease, such as VZV-associated meningitis.

scholarly journals Herpes Zoster Infection Presenting as Aseptic Meningitis and Dermatomal Rash in Immunocompetent Adult

2020 ◽  
Vol 2020 ◽  
pp. 1-3 ◽  
Author(s):  
Suyash Dawadi ◽  
Sudesh Lamsal ◽  
Bhupendra Shah
Keyword(s):  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Aseptic Meningitis ◽  
Elderly Population ◽  
Virus Reactivation ◽  
Herpes Zoster Infection ◽  
Immunocompetent Adult ◽  
Varicella Zoster ◽  
Vesicular Rash ◽  
Immunocompromised Status

Herpes zoster is a localized, painful, and vesicular rash involving one or adjacent dermatomes caused by varicella-zoster virus reactivation. Herpes zoster presenting as aseptic meningitis is prevalent among elderly population and people with immunocompromised status. However, it is a rare phenomenon in the young immunocompetent adult; hence, we are reporting a case of a herpes zoster infection presenting as aseptic meningitis and dermatological manifestation in a 19-year-old immunocompetent male.

scholarly journals Multi-organ involvement secondary to varicella zoster virus, herpes simplex virus and cytomegalovirus in an immunocompromised patient

2019 ◽  
Vol 12 (3) ◽  
pp. e228150 ◽  
Author(s):  
Ripal Jariwala ◽  
Kristen Zeitler ◽  
Nicole D Riddle ◽  
Chakrapol Sriaroon
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Immunocompromised Patient ◽  
Case Reports ◽  
Skin Lesions ◽  
Viral Reactivation ◽  
Organ Involvement ◽  
Varicella Zoster ◽  
Simplex Virus

The use of immunosuppressing agents can act as a catalyst for viral reactivation, promoting systemic infection with organ involvement. Current literature remains sparse on this topic but does provide individual case reports involving single viruses. We present the case of an immunocompromised patient with skin lesions, pancreatitis, colitis and hepatitis. Work-up revealed varicella zoster virus, which likely put the patient at risk for multi-organ involvement, as well as clinical suspicion of other implicated viruses, specifically herpes simplex virus and cytomegalovirus. A high clinical index of suspicion along with biopsy guidance for viral involvement in immunocompromised patients is crucial for early diagnosis and treatment of these conditions.

scholarly journals Varicella-Zoster Virus Proteins in Skin Lesions: Implications for a Novel Role of ORF29p in Chickenpox

2000 ◽  
Vol 74 (4) ◽  
pp. 2005-2010 ◽  
Author(s):  
Paula W. Annunziato ◽  
Octavian Lungu ◽  
Christos Panagiotidis ◽  
Jing H. Zhang ◽  
David N. Silvers ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Skin Biopsy ◽  
Varicella Zoster Virus ◽  
Nuclear Protein ◽  
Cell Types ◽  
Skin Lesions ◽  
Varicella Zoster ◽  
Human Neurons ◽  
Virus Proteins

ABSTRACT Skin biopsy samples from varicella-zoster virus (VZV)-infected patients examined by immunohistochemistry demonstrated VZV replication in nonepithelial cell types. ORF29p, a nonstructural nuclear protein, was found in nerves of two of six patients with chickenpox. In tissue culture, ORF29p was secreted by VZV-infected fibroblasts. Extracellular ORF29p can be taken up through endocytosis by human neurons, implying a novel role for this protein in pathogenesis.

Sign in / Sign up

Export Citation Format

Share Document