Motor radiculopathy caused by varicella zoster virus without skin lesions (‘zoster sine herpete’)

2010 ◽  
Vol 112 (10) ◽  
pp. 933 ◽  
Author(s):  
B.C. ter Meulen ◽  
J.J.G. Rath
Keyword(s):  
Varicella Zoster Virus ◽  
Skin Lesions ◽  
Varicella Zoster ◽  
Zoster Sine Herpete

scholarly journals Varicella Zoster Virus-Associated Meningitis as a Rebound Varicella Zoster Disease after Antiviral Discontinuation

2021 ◽  
pp. 148-153
Author(s):  
Tetsuko Sato ◽  
Takenobu Yamamoto ◽  
Yumi Aoyama
Keyword(s):  
Herpes Zoster ◽  
Early Diagnosis ◽  
Varicella Zoster Virus ◽  
Immunosuppressive Therapy ◽  
Unusual Case ◽  
Cranial Nerves ◽  
Skin Lesions ◽  
Immunocompromised Patients ◽  
Aggressive Treatment ◽  
Varicella Zoster

Varicella zoster virus (VZV)-associated meningitis is usually progressive and can be fatal, and early diagnosis and aggressive treatment with intravenous antivirals such as acyclovir (ACV) are required in immunocompromised patients. Patients receiving corticosteroids and immunosuppressive therapy have a significantly higher risk of VZV-associated meningitis. In this report, we describe an unusual case of herpes zoster (HZ) in a young woman who was first diagnosed during tapering of prednisone for dermatomyositis. The skin lesions affected the left L2 and L3 dermatomes, which is unusual in VZV-associated meningitis. Despite showing a good rapid response to antivirals, she developed VZV-associated meningitis immediately after discontinuation of ACV. This phenomenon is often called rebound VZV reactivation disease and occurs after discontinuation of antivirals. This case was notable in that the affected dermatomes were distant from the cranial nerves. Thus, progression of HZ to VZV reactivation-associated meningitis can occur even in appropriately treated HZ patients. Continuation of antivirals beyond 1 week in patients on immunosuppressive therapy may be associated with a decreased risk of severe rebound VZV disease, such as VZV-associated meningitis.

scholarly journals Multi-organ involvement secondary to varicella zoster virus, herpes simplex virus and cytomegalovirus in an immunocompromised patient

2019 ◽  
Vol 12 (3) ◽  
pp. e228150 ◽  
Author(s):  
Ripal Jariwala ◽  
Kristen Zeitler ◽  
Nicole D Riddle ◽  
Chakrapol Sriaroon
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Immunocompromised Patient ◽  
Case Reports ◽  
Skin Lesions ◽  
Viral Reactivation ◽  
Organ Involvement ◽  
Varicella Zoster ◽  
Simplex Virus

The use of immunosuppressing agents can act as a catalyst for viral reactivation, promoting systemic infection with organ involvement. Current literature remains sparse on this topic but does provide individual case reports involving single viruses. We present the case of an immunocompromised patient with skin lesions, pancreatitis, colitis and hepatitis. Work-up revealed varicella zoster virus, which likely put the patient at risk for multi-organ involvement, as well as clinical suspicion of other implicated viruses, specifically herpes simplex virus and cytomegalovirus. A high clinical index of suspicion along with biopsy guidance for viral involvement in immunocompromised patients is crucial for early diagnosis and treatment of these conditions.

scholarly journals Varicella-Zoster Virus Proteins in Skin Lesions: Implications for a Novel Role of ORF29p in Chickenpox

2000 ◽  
Vol 74 (4) ◽  
pp. 2005-2010 ◽  
Author(s):  
Paula W. Annunziato ◽  
Octavian Lungu ◽  
Christos Panagiotidis ◽  
Jing H. Zhang ◽  
David N. Silvers ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Skin Biopsy ◽  
Varicella Zoster Virus ◽  
Nuclear Protein ◽  
Cell Types ◽  
Skin Lesions ◽  
Varicella Zoster ◽  
Human Neurons ◽  
Virus Proteins

ABSTRACT Skin biopsy samples from varicella-zoster virus (VZV)-infected patients examined by immunohistochemistry demonstrated VZV replication in nonepithelial cell types. ORF29p, a nonstructural nuclear protein, was found in nerves of two of six patients with chickenpox. In tissue culture, ORF29p was secreted by VZV-infected fibroblasts. Extracellular ORF29p can be taken up through endocytosis by human neurons, implying a novel role for this protein in pathogenesis.

scholarly journals Case report: aseptic meningitis secondary to varicella-zoster virus (VZV) without an exanthem post MMR vaccination

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Syeda Sahra ◽  
Abdullah Jahangir ◽  
Allison Glaser ◽  
Neville Mobarakai ◽  
Ahmad Jahangir
Keyword(s):  
Case Report ◽  
Varicella Zoster Virus ◽  
Aseptic Meningitis ◽  
Immunocompetent Patient ◽  
Mmr Vaccine ◽  
Case Presentation ◽  
Varicella Zoster ◽  
Zoster Sine Herpete ◽  
History Of

Abstract Background Varicella-zoster virus (VZV) is a known cause of aseptic meningitis, with a predisposition for an immunocompromised population. A dermatomal rash usually accompanies aseptic meningitis secondary to VZV. Case presentation We report the case of a 31-year-old male with a history of chickenpox in childhood and recent shingles who presented with severe frontal headaches secondary to VZV meningitis. The patient had also recently received the measles-mumps-rubella (MMR) vaccine. He recovered without any neurological sequala. Conclusion This case report describes an immunocompetent patient with recent MMR vaccination who developed aseptic meningitis secondary to VZV without any dermatomal involvement (Zoster Sine Herpete).

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