Severe hyperbilirubinemia and acute renal failure associated with hepatitis E in a patient whose glucose-6-phosphate dehydrogenase levels were normal

2013 ◽  
Vol 17 (4) ◽  
pp. 596-597 ◽  
Author(s):  
Sanjay Vikrant ◽  
Satish Kumar
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Hepatitis E ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Severe Hyperbilirubinemia

Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon

2019 ◽  
Vol 69 (8) ◽  
pp. 1440-1442 ◽  
Author(s):  
Jose Diego Brito-Sousa ◽  
Thalie C Santos ◽  
Sara Avalos ◽  
Gustavo Fontecha ◽  
Gisely C Melo ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Plasmodium Vivax ◽  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Brazilian Amazon ◽  
Clinical Spectrum ◽  
Life Threatening ◽  
Endemic Areas ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract Despite glucose-6-phosphate dehydrogenase (G6PD) deficiency prevalence of 5% in the Amazon, primaquine is administered without G6PD screening. This is an important cause of hospitalization among Plasmodium vivax–infected individuals, leading to life-threatening anemia and acute renal failure across endemic areas. In Manaus, the frequency of primaquine-induced hemolysis was 85.2 cases per 100 000 primaquine users.

scholarly journals Potential Benefit of Plasma Exchange in Treatment of Severe Icteric Leptospirosis Complicated by Acute Renal Failure

2002 ◽  
Vol 9 (2) ◽  
pp. 482-484 ◽  
Author(s):  
Kai-Chung Tse ◽  
Pok-Siu Yip ◽  
King-Men Hui ◽  
Fu-Keung Li ◽  
Kwok-Yung Yuen ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Plasma Exchange ◽  
Cell Function ◽  
Clinical Manifestations ◽  
Renal Tubular Cell ◽  
Beneficial Effects ◽  
Hemorrhagic Tendency ◽  
Renal Tubular ◽  
Severe Hyperbilirubinemia

ABSTRACT Leptospirosis is a common zoonosis seen worldwide, but it is rare in our locality (Hong Kong). Clinical manifestations of leptospirosis are variable and may range from subclinical infection to fever, jaundice, hemorrhagic tendency, and fulminant hepato-renal failure. Severe hyperbilirubinemia and acute renal failure have been associated with high mortality. We report our experience with a patient who developed severe Weil's syndrome with marked conjugated hyperbilirubinemia and oliguric acute renal failure. These complications persisted despite treatment with penicillin and hemodiafiltration. Plasma exchange was instituted in view of the severe hyperbilirubinemia (970 μmol/liter). This was followed by prompt clinical improvement, with recovery of liver and renal function. The beneficial effects of plasma exchange could be attributed to amelioration of the toxic effects of hyperbilirubinemia on hepatocyte and renal tubular cell function. We conclude that plasma exchange should be considered as an adjunctive therapy for patients with severe icteric leptospirosis complicated by acute renal failure who have not shown rapid clinical response to conventional treatment.

Acute Renal Failure Amongst Children in a Tropical Environment

1987 ◽  
Vol 10 (2) ◽  
pp. 97-101 ◽  
Author(s):  
K.S. Chugh ◽  
A. Narang ◽  
L. Kumar ◽  
V. Sakhuja ◽  
V. Narayanan Unni ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Rural Areas ◽  
Acute Interstitial Nephritis ◽  
Acute Glomerulonephritis ◽  
Drug Induced ◽  
Tubular Necrosis ◽  
Renal Histology ◽  
Endocapillary Proliferative Glomerulonephritis ◽  
Glucose 6 Phosphate Dehydrogenase

The pathogenetic factors leading to acute renal failure (ARF) in 223 children between the ages of 20 days and 14 years were studied. Diarrhoeal diseases were responsible for ARF in 49.8%, acute glomerulonephritis in 34.1%, drug induced intravascular hemolysis in glucose -6-phosphate dehydrogenase deficiency in 4.5%, snake bite in 4%, hemolytic uremic syndrome in 2.2%, and miscellaneous causes in 5.4%. Dialysis was instituted in 178 children and the others were treated conservatively. Renal histology in 39 out of 76 children who presented with an acute nephritic illness revealed acute endocapillary proliferative glomerulonephritis in 27 and crescentic glomerulonephritis in 12. The histology in 79 out of 147 remaining patients showed acute tubular necrosis in 64, acute cortical necrosis in 13, and acute interstitial nephritis in 2. Overall mortality was 27.4%. This high incidence of ARF due to infective diarrhoeas and dysentery reflects poor socio-economic and hygienic conditions, inadequate facilities in rural areas, delays in seeking medical advice, and lack of knowledge about fluid and electrolyte therapy amongst the staff.

scholarly journals Non-oliguric acute renal failure associated with hepatitis E

1997 ◽  
Vol 12 (4) ◽  
pp. 799-801 ◽  
Author(s):  
E. A. Verschuuren ◽  
E. B. Haagsma ◽  
J. G. Zijlstra ◽  
C. A. Stegeman
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Hepatitis E ◽  
Oliguric Acute Renal Failure

scholarly journals Acute renal failure in favism revealing familial glucose-6-phosphate dehydrogenase deficiency

2012 ◽  
Vol 22 (1) ◽  
pp. 67 ◽  
Author(s):  
DI Montasser ◽  
Y Zajjari ◽  
A Alayoud ◽  
Z Oualim ◽  
M Benyahia ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Dehydrogenase Deficiency ◽  
Glucose 6 Phosphate Dehydrogenase

scholarly journals Falsely Elevated Acetaminophen Levels in the Setting of Hyperbilirubinemia

2013 ◽  
Vol 2 (2) ◽  
pp. 74-77
Author(s):  
Parth J Parekh ◽  
Thomas J Manser
Keyword(s):  
Internal Medicine ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Alcoholic Hepatitis ◽  
Review Of The Literature ◽  
Severe Liver ◽  
Heavy Alcohol ◽  
History Of ◽  
Severe Liver Disease ◽  
Severe Hyperbilirubinemia

A 51-year-old male with a history of heavy alcohol abuse presented with alcoholic hepatitis and acute renal failure. Although he denied acetaminophen (APAP) ingestion, he was found to have elevated APAP levels that persisted and actually increased despite treatment with N-acetylcysteine. Review of the literature reveals that falsely elevated APAP levels may rarely occur with patients suffering from liver failure and felt to be related to severe hyperbilirubinemia. Interpretation of APAP levels in patients with severe liver disease and hyperbilirubinemia may be difficult and lead to diagnostic and therapeutic confusion. DOI: http://dx.doi.org/10.3126/jaim.v2i2.8782   Journal of Advances in Internal Medicine 2013;02(02):74-77

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