A unique biolistic method of vaccination is operated by accelerating particulate vaccines with a high-speed gas jet generated by a convergent-divergent conical nozzle to sufficient momentum to penetrate the outer layer of human skin. The targeted cells elicit an immunological response. In this paper, Computational Fluid Dynamics (CFD) is utilized to simulate the operation of a prototype biolistics delivery system. The key features of transient gas dynamics and gas-particle interaction are discussed.
Numerical investigation of gas dynamics in nozzles of small-dimensioned gas generators and flowing out jets