MRI Study for the Features of Brain Conduction Pathways in Patients with an Ultra-High Risk of Endogenous Psychoses

2017 ◽  
Vol 162 (4) ◽  
pp. 425-429 ◽  
Author(s):  
A. S. Tomyshev ◽  
I. S. Lebedeva ◽  
T. A. Akhadov ◽  
M. A. Omel’chenko ◽  
M. V. Ublinskii ◽  
...  
Keyword(s):  
High Risk ◽  
Endogenous Psychoses ◽  
Ultra High Risk ◽  
Mri Study

Anatomic Abnormalities of the Anterior Cingulate Cortex Before Psychosis Onset: An MRI Study of Ultra-High-Risk Individuals

2008 ◽  
Vol 64 (9) ◽  
pp. 758-765 ◽  
Author(s):  
Alex Fornito ◽  
Alison R. Yung ◽  
Stephen J. Wood ◽  
Lisa J. Phillips ◽  
Barnaby Nelson ◽  
...  
Keyword(s):  
High Risk ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Ultra High Risk ◽  
Mri Study

Global fractional anisotropy predicts transition to psychosis after 12 months in individuals at ultra‐high risk for psychosis

2021 ◽  
Author(s):  
Tina D. Kristensen ◽  
Louise B. Glenthøj ◽  
Karen Ambrosen ◽  
Warda Syeda ◽  
Jayachandra M. Ragahava ◽  
...  
Keyword(s):  
High Risk ◽  
Fractional Anisotropy ◽  
Ultra High Risk

scholarly journals Treating sleep problems in young people at ultra-high-risk of psychosis: study protocol for a single-blind parallel group randomised controlled feasibility trial (SleepWell)

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e045235
Author(s):  
Felicity Waite ◽  
Thomas Kabir ◽  
Louise Johns ◽  
Jill Mollison ◽  
Apostolos Tsiachristas ◽  
...  
Keyword(s):  
Mental Health ◽  
High Risk ◽  
Young People ◽  
Sleep Problems ◽  
Qualitative Interviews ◽  
Feasibility Trial ◽  
Psychotic Experiences ◽  
Post Intervention ◽  
Ultra High Risk ◽  
Randomised Controlled

BackgroundEffective interventions, targeting key contributory causal factors, are needed to prevent the emergence of severe mental health problems in young people. Insomnia is a common clinical issue that is problematic in its own right but that also leads to the development and persistence of psychotic experiences. The implication is that treating sleep problems may prevent the onset of psychosis. We collected initial case series data with 12 young people at ultra-high-risk of psychosis. Post-intervention, there were improvements in sleep, depression and psychotic experiences. Now we test the feasibility of a randomised controlled trial, with a clinical aim to treat sleep problems and hence reduce depression, psychotic experiences, and prevent transition to psychosis.Methods and analysisA randomised controlled feasibility trial will be conducted. Forty patients aged 14 to 25 years who are at ultra-high-risk of psychosis and have sleep disturbance will be recruited from National Health Service (NHS) mental health services. Participants will be randomised to receive either a novel, targeted, youth-focussed sleep intervention in addition to usual care or usual care alone. Assessor-blinded assessments will be conducted at baseline, 3 months (post-intervention) and 9 months (follow-up). The eight-session psychological intervention will target the key mechanisms which disrupt sleep: circadian rhythm irregularities, low sleep pressure, and hyperarousal. To gain an in-depth understanding of participants’ views on the acceptability of the intervention and study procedures, 16 participants (n=10 intervention, n=6 control) will take part in qualitative interviews. Analyses will focus on feasibility outcomes (recruitment, retention, and treatment uptake rates) and provide initial CI estimates of intervention effects. Thematic analysis of the qualitative interviews will assess the acceptability of the intervention and trial procedures.Ethics and disseminationThe trial has received ethical approval from the NHS Health Research Authority. Findings will be disseminated through peer-reviewed publications, conference presentations, and lay networks.Trial registration numberISRCTN85601537.

scholarly journals Fluvoxamine may prevent onset of psychosis: a case report of a patient at ultra-high risk of psychotic disorder

2011 ◽  
Vol 10 (1) ◽  
pp. 26 ◽  
Author(s):  
Shigenori Tadokoro ◽  
Nobuhisa Kanahara ◽  
Shuichi Kikuchi ◽  
Kenji Hashimoto ◽  
Iyo Masaomi
Keyword(s):  
Case Report ◽  
High Risk ◽  
Psychotic Disorder ◽  
Ultra High Risk
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