Comparison between MDCK and MDCK-SIAT1 cell lines as preferred host for cell culture-based influenza vaccine production

2016 ◽  
Vol 38 (6) ◽  
pp. 941-948 ◽  
Author(s):  
Asghar Abdoli ◽  
Hoorieh Soleimanjahi ◽  
Abbas Jamali ◽  
Parvaneh Mehrbod ◽  
Shima Gholami ◽  
...  
Keyword(s):  
Cell Culture ◽  
Influenza Vaccine ◽  
Cell Lines ◽  
Vaccine Production ◽  
Influenza Vaccine Production

The future of cell culture-based influenza vaccine production

2011 ◽  
Vol 10 (8) ◽  
pp. 1183-1194 ◽  
Author(s):  
Michael L Perdue ◽  
Frank Arnold ◽  
Sheng Li ◽  
Armen Donabedian ◽  
Vittoria Cioce ◽  
...  
Keyword(s):  
Cell Culture ◽  
Influenza Vaccine ◽  
Vaccine Production ◽  
The Future ◽  
Influenza Vaccine Production

scholarly journals SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines

2020 ◽  
Vol 25 (25) ◽  
Author(s):  
Ian G Barr ◽  
Cleve Rynehart ◽  
Paul Whitney ◽  
Julian Druce
Keyword(s):  
Influenza Vaccine ◽  
Cell Lines ◽  
Potential Risk ◽  
Mdck Cell ◽  
Influenza Viruses ◽  
Influenza Vaccines ◽  
Vaccine Production ◽  
Human Influenza ◽  
Continuous Cell Lines ◽  
Influenza Vaccine Production

The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production platforms as respiratory samples are used to directly inoculate embryonated hen’s eggs and continuous cell lines that are used to isolate and produce influenza vaccines. We investigated the ability of these substrates to propagate SARS-CoV-2 and found that neither could support SARS-CoV-2 replication.

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