Large populations of the exotic rounded (noncarinate) shelled mussel of the genus Dreissena were found to exist on soft sediments collected throughout the central and eastern basins of Lake Erie during July and August 1992. Two different phenotypes were present on fine sediments (<150 μm) in the eastern basin. An elongated white morph was common on the profundal sediments beyond 40 m depth, while the "quagga" mussel was common on sand and sandy silt at depths between 10 and 30 m. Together with the carinated zebra mussel Dreissena polymorpha, which is very abundant on hard substrates in the sublittoral region, at least 80% of Lake Erie's bottom sediments have been invaded by Dreissena. Only that region of the central basin (near Cleveland) which undergoes periodic summer anoxia was not inhabited by this genus.