Modification of breast cancer risk according to age and menopausal status: a combined analysis of five population-based case–control studies

Abstract Background :The effect of the p.Arg72Pro variant of the P53 gene on the risk of developmentof breast cancer remains variable in populations. However, the use of strategiessuchas pooling age-matched controls with disease cases may provide a solid meta-analysis. Our goal was to perform a meta-analysis in order to assessthe association of p.Arg72Provariant of P53 gene with breast cancer risk. Methods : Databases such as PubMed, Genetics Medical Literature, Harvard University Library, Web of Science and Genesis Library were used to search articles. Age-matched case-control studies on breast cancer that have evaluated the genotype frequencies of the p.Arg72Pro of P53 gene were selected. The fixed and random effects (Mantel-Haenszel) were calculated using pooled odds ratio of 95% CI to determine the risk of disease. Inconsistency was calculated to determine heterogeneity among the studies. The publication bias was estimated using the funnel plot. Results : Twenty-one publications with cases age-matched controls including7841disease cases and 8876controls were evaluated in this meta-analysis. Overall, our results suggested that p.Arg72ProP53 was associated with a risk for breast cancer for the dominant model (OR= 1.09, 95% CI = 1.02-1.16; P= 0.01) and the additive model (OR= 1.09, 95% CI = 1.01-1.17; P= 0.03), but not in the recessive model (OR = 1.07, 95% CI = 0.97-1.16; P= 0.19). According to the ethnic group, allele Pro has been associated with breast cancer risk in Europeans for the dominant and additive models. Conclusions : This meta-analysis found a significant association between p.Arg72Pro in the P53 gene and the risk of breast cancer. Individuals carrying at least one Pro allele of the P53 gene are more likely to have breast cancer with dominant and additive models than individualsharboringthe Arg allele.

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Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk.

Rehabilitation Oncology ◽

10.1097/01893697-200119020-00017 ◽

2001 ◽

Vol 19 (2) ◽

pp. 27

Author(s):

D Xie ◽

XO Shu ◽

Z Deng ◽

WQ Wen ◽

KE Creek ◽

...

Keyword(s):

Breast Cancer ◽

Genetic Polymorphism ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Control Study

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Light at night and breast cancer risk: results from a population-based case–control study in Connecticut, USA

Cancer Causes & Control ◽

10.1007/s10552-010-9653-z ◽

2010 ◽

Vol 21 (12) ◽

pp. 2281-2285 ◽

Cited By ~ 20

Author(s):

Qian Li ◽

Tongzhang Zheng ◽

Theodore R. Holford ◽

Peter Boyle ◽

Yawei Zhang ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Light At Night ◽

Control Study

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Abstract 270: The association between medical history and breast cancer risk: A nationwide population-based case-control study using claim data

10.1158/1538-7445.am2014-270 ◽

2014 ◽

Author(s):

Shu-Chun Chuang ◽

Guo-Jie Wu ◽

Yen-Shen Lu ◽

Ching-Hung Lin ◽

Chao Agnes Hsiung

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Medical History ◽

Case Control Study ◽

Claim Data ◽

Population Based ◽

Case Control ◽

Control Study

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Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study

Nutrients ◽

10.3390/nu11081871 ◽

2019 ◽

Vol 11 (8) ◽

pp. 1871 ◽

Cited By ~ 1

Author(s):

Jordana Carolina Marques Godinho-Mota ◽

Larissa Vaz Gonçalves ◽

Joao Felipe Mota ◽

Leonardo Ribeiro Soares ◽

Raquel Machado Schincaglia ◽

...

Keyword(s):

Breast Cancer ◽

Alcohol Consumption ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Sedentary Behavior ◽

Case Control Study ◽

Menopausal Status ◽

Case Control ◽

Alcoholic Beverages ◽

Control Study

Identification of modifiable risk factors for breast cancer is critical for primary prevention of the disease. The aim of this study was to evaluate how certain lifestyle variables modify the chances of developing breast cancer based on menopausal status. A case-control study was performed in a group of 542 women, 197 who were diagnosed with breast cancer and 344 control individuals. The groups were matched by age, body mass index, and menopausal status. Participants were evaluated for level of physical activity, alcohol consumption, smoking habit, weight, height, and waist circumference (WC). A multivariate logistic regression model was used to estimate odds ratios and 95% confidence intervals (95% CI). Regular consumption of alcoholic beverages (2.91, 95% CI 1.58–5.38 and 1.86, 95% CI 1.15–3.03) and sedentary behavior (2.08; 95% CI 1.12–3.85 and 1.81; 95% CI 1.12–2.94) were associated with breast cancer risk in pre- and postmenopausal women, respectively. High WC (3.31, 95% CI 1.45–7.55) was associated with an increased risk of developing breast cancer in premenopausal women. While in postmenopausal women, current smoking (2.43, 95% CI 1.01–5.83) or previous history of smoking (1.90; 95% CI 1.14–3.14) increased the chances of developing breast cancer. Sedentary behavior and current consumption of alcoholic beverages were more likely to increase the risk of developing breast cancer regardless of menopausal status.

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