Cancer Causes & Control
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Published By Springer-Verlag

1573-7225, 0957-5243

Stephanie Navarro ◽  
Xiaohui Hu ◽  
Aaron Mejia ◽  
Carol Y. Ochoa ◽  
Trevor A. Pickering ◽  

Luis G. Parra-Lara ◽  
Diana M. Mendoza-Urbano ◽  
Ángela R. Zambrano ◽  
Andrea Valencia-Orozco ◽  
Juan C. Bravo-Ocaña ◽  

Signe Benzon Larsen ◽  
Christian Dehlendorff ◽  
Charlotte Skriver ◽  
Anton Pottegård ◽  
Søren Friis ◽  

Denise Danos ◽  
Claudia Leonardi ◽  
Xiao-Cheng Wu

Abstract Purpose Currently, rural residents in the United States (US) experience a greater cancer burden for tobacco-related cancers and cancers that can be prevented by screening. We aim to characterize geographic determinants of colorectal cancer (CRC) incidence in Louisiana due to rural residence and other known geographic risk factors, area socioeconomic status (SES), and cultural region (Acadian or French-speaking). Methods Primary colorectal cancer diagnosed among adults 30 years and older in 2008–2017 were obtained from the Louisiana Tumor Registry. Population and social and economic data were obtained from US Census American Community Survey. Rural areas were defined using US Department of Agriculture 2010 rural–urban commuting area codes. Estimates of relative risk (RR) were obtained from multilevel binomial regression models of incidence. Results The study population was 16.1% rural, 18.4% low SES, and 17.9% Acadian. Risk of CRC was greater among rural white residents (RR Women: 1.09(1.02–1.16), RR Men: 1.11(1.04–1.18)). Low SES was associated with increased CRC for all demographic groups, with excess risk ranging from 8% in Black men (RR: 1.08(1.01–1.16)) to 16% in white men (RR: 1.16(1.08–1.24)). Increased risk in the Acadian region was greatest for Black men (RR: 1.21(1.10–1.33)) and women (RR: 1.21(1.09–1.33)). Rural–urban disparities in CRC were no longer significant after controlling for SES and Acadian region. Conclusion SES remains a significant determinant of CRC disparities in Louisiana and may contribute to observed rural–urban disparities in the state. While the intersectionality of CRC risk factors is complex, we have confirmed a robust regional disparity for the Acadian region of Louisiana.

Zhenzhen Zhang ◽  
Grace Curran ◽  
Kenneth Xu ◽  
Jeong Youn Lim ◽  
Paige E. Farris ◽  

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