scholarly journals Loss of protein tyrosine phosphatase, non-receptor type 2 is associated with activation of AKT and tamoxifen resistance in breast cancer

2015 ◽  
Vol 153 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Elin Karlsson ◽  
Cynthia Veenstra ◽  
Shad Emin ◽  
Chhanda Dutta ◽  
Gizeh Pérez-Tenorio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Tamoxifen Resistance ◽  
Receptor Type ◽  
Protein Tyrosine

scholarly journals Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance

2020 ◽  
Vol 11 ◽  
Author(s):  
Larissa Hering ◽  
Egle Katkeviciute ◽  
Marlene Schwarzfischer ◽  
Philipp Busenhart ◽  
Claudia Gottier ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine

scholarly journals The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort

Digestion ◽  
2016 ◽  
Vol 93 (3) ◽  
pp. 182-192 ◽  
Author(s):  
Marianne R. Spalinger ◽  
Marius Voegelin ◽  
Luc Biedermann ◽  
Jonas Zeitz ◽  
Jean-Benoit Rossel ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Clinical Relevance ◽  
Gene Locus ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine ◽  
Risk Gene ◽  
Encoding Protein

Tu1740 Matriptase-1 Modulation of Claudin-2 Is Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) Dependent

2013 ◽  
Vol 144 (5) ◽  
pp. S-834
Author(s):  
Ronald R. Marchelletta ◽  
Taylaur W Smith ◽  
Jessica A. Bañuelos ◽  
Carli Smith ◽  
Brian Houng ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine

Protein Tyrosine Phosphatase Non-Receptor Type 2 Regulates NLRP3 Inflammasome Activation

2011 ◽  
Vol 140 (5) ◽  
pp. S-633
Author(s):  
Helen M. Becker ◽  
Barbara Schnell ◽  
Joba M. Arikkat ◽  
Markus Schuppler ◽  
Martin J. Loessner ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Nlrp3 Inflammasome ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Inflammasome Activation ◽  
Protein Tyrosine ◽  
Nlrp3 Inflammasome Activation

scholarly journals Activation of Protein Tyrosine Phosphatase Non-Receptor Type 2 by Spermidine Exerts Anti-Inflammatory Effects in Human THP-1 Monocytes and in a Mouse Model of Acute Colitis

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73703 ◽  
Author(s):  
Belén Morón ◽  
Marianne Spalinger ◽  
Stephanie Kasper ◽  
Kirstin Atrott ◽  
Isabelle Frey-Wagner ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Acute Colitis ◽  
Protein Tyrosine ◽  
Anti Inflammatory

IL-6 influences PD-L1 expression in monocytes and macrophages by effecting protein tyrosine phosphatase receptor type O expression in-human breast cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15570-e15570
Author(s):  
Lin Chen ◽  
Jinhai Tang
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Protein Tyrosine Phosphatase ◽  
Human Breast Cancer ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Human Breast ◽  
Protein Tyrosine ◽  
Monocytes And Macrophages

e15570 Background: We have previously discovered a relationship between the low expression of protein tyrosine phosphatase, receptor type O (PTPRO) in tumor-infiltrating T cells and immunosuppression. The aim of the present study was to investigate the relationship between decreased PTPRO and increased programmed death ligand 1 (PD-L1) in both the peripheral monocytes and tumor-infiltrating macrophages of human breast cancer (BC). Methods: The expression and correlation of all the indices were explored in monocytes and tumor infiltrating macrophages within both human and mice BC. The mechanic regulations were studied by using both in vitro and in vivo studies. Results: We found a significant decrease in PTPRO in BC peripheral monocytes that was associated with increased PD-L1 expression in peripheral monocytes and tumor-associated macrophages (TAMs) in BC. Monocyte PD-L1 and PTPRO therefore could serve as valuable prognostic indicators for post-surgery patients with BC and were associated with increased T cell exhaustion (Tim3+ T cells). A depletion of PTPRO promoted PD-L1 secretion in both monocytes and macrophages through the JAK2/STAT1 and JAK2/STAT3/c-MYC pathways. Increased IL-6 expression was associated with activation of JAK2/STAT3/c-MYC and with decreased PTPRO expression through the STAT3/c-MYC/miR-25-3p axis. Monocytes and TAMs showed significantly increased miR-25-3p expression, which could target the 3' untranslated region of PTPRO. The miR-25-3p expression positively correlated with serum IL-6 levels, but inversely correlated with PTPRO in BC monocytes. IL-6/STAT3/c-MYC activation enhanced in vitro miR-25-3p transcription and decreased PTPRO, while further promoting PD-L1 secretion. Adoptive cell transfer of c-MYC/miR-25-3p–modified monocytes promoted tumor growth by downregulating PTPRO and causing a PD-L1–induced immunosuppression in breast tumor model. Conclusions: Increased serum IL-6 downregulated PTPRO expression in BC monocytes and macrophages by activating STAT3/c-MYC/miR-25-3p and by further enhancing PD-L1 expression through JAK2/STAT1 and JAK2/STAT3/c-MYC signaling.

Evaluation of MicroRNA-210 and Protein tyrosine phosphatase, non-receptor type 2 in Pre-eclampsia

Gene ◽  
2017 ◽  
Vol 596 ◽  
pp. 105-109 ◽  
Author(s):  
Sherihan Adel ◽  
Amal Mansour ◽  
Manal Louka ◽  
M Matboli ◽  
S F Elmekkawi ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine
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