Genotoxicity of chloroquine in rat liver cells: Protective role of free radical scavengers

2006 ◽  
Vol 22 (3) ◽  
pp. 159-167 ◽  
Author(s):  
E. O. Farombi
Keyword(s):  
Free Radical ◽  
Rat Liver ◽  
Protective Role ◽  
Liver Cells ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Rat Liver Cells

Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants

Toxicology ◽  
2011 ◽  
Vol 289 (2-3) ◽  
pp. 175-184 ◽  
Author(s):  
Irene Antolino-Lobo ◽  
Jan Meulenbelt ◽  
Jeffrey Molendijk ◽  
Sandra M. Nijmeijer ◽  
Peter Scherpenisse ◽  
...  
Keyword(s):  
Rat Liver ◽  
Protective Role ◽  
Liver Cells ◽  
Glutathione Synthesis ◽  
Rat Liver Cells

Effects of free radical generation on mouse pial arterioles: probable role of hydroxyl radicals

1983 ◽  
Vol 245 (1) ◽  
pp. H139-H142 ◽  
Author(s):  
W. I. Rosenblum
Keyword(s):  
Free Radical ◽  
Xanthine Oxidase ◽  
Hydroxyl Radicals ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Pial Arterioles ◽  
Probable Role ◽  
Radical Generation ◽  
Superoxide Scavenger

Mouse pial arterioles were exposed to the free radical-generating reactants acetaldehyde and xanthine oxidase. Concentrations of 0.5 mM acetaldehyde and 0.1 U/ml xanthine oxidase caused reversible dilations, whereas higher concentrations produced initial constrictions followed by reversible dilations. The following free radical scavengers inhibited the dilation when added to the lower concentrations of reactants: superoxide dismutase, a superoxide scavenger; catalase, an H2O2 scavenger; and mannitol, a hydroxyl scavenger. In addition, pretreatment of the animal with dimethyl sulfoxide, a hydroxyl scavenger, also inhibited the response. The scavengers were also tested against either the dilation produced by increased inspired CO2 or against the dilation produced by local application of 10(-3) M papaverine. No significant effect was observed. The data support the hypothesis that hydroxyl radicals can dilate pial arterioles, since all the scavengers can ultimately reduce levels of hydroxyl generated by acetaldehyde plus xanthine oxidase.

scholarly journals Changes in oxygen consumption induced by t-butyl hydroperoxide in perfused rat liver. Effect of free-radical scavengers

1984 ◽  
Vol 223 (3) ◽  
pp. 879-883 ◽  
Author(s):  
L A Videla ◽  
M I Villena ◽  
G Donoso ◽  
C Giulivi ◽  
A Boveris
Keyword(s):  
Oxygen Consumption ◽  
Free Radical ◽  
Oxygen Uptake ◽  
Rat Liver ◽  
Recovery Phase ◽  
Free Radical Scavengers ◽  
Perfused Rat Liver ◽  
Radical Scavengers ◽  
Butyl Hydroperoxide ◽  
Biphasic Effect

The addition of t-butyl hydroperoxide to perfused rat liver elicited a biphasic effect on hepatic respiration. A rapid fall in liver oxygen consumption was initially observed, followed by a recovery phase leading to respiratory rates higher than the initial steady-state values of oxygen uptake. This overshoot in hepatic oxygen uptake was abolished by free-radical scavengers such as (+)-cyanidanol-3 or butylated hydroxyanisole at concentrations that did not alter mitochondrial respiration. (+)-Cyanidanol-3 was also able to facilitate the recovery of respiration, the diminution in the calculated rate of hydroperoxide utilization and the decrease in liver GSH content produced by two consecutive pulses of t-butyl hydroperoxide. It is suggested that the t-butyl hydroperoxide-induced overshoot in liver respiration is related to increased utilization of oxygen for lipid peroxidation as a consequence of free radicals produced in the scission of the hydroperoxide by cellular haemoproteins.

Ceruloplasmin Expression in Rat Liver Cells is Attenuated by Insulin: Role of FoxO Transcription Factors

2011 ◽  
Vol 43 (04) ◽  
pp. 268-274 ◽  
Author(s):  
M. Leyendecker ◽  
P. Korsten ◽  
R. Reinehr ◽  
B. Speckmann ◽  
D. Schmoll ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Rat Liver ◽  
Liver Cells ◽  
Rat Liver Cells ◽  
Foxo Transcription Factors
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