Synthesis and biological activity of 3,4-dihydropyrimidin-2-thione aminomethylene derivatives based on the alkaloid cytisine

2011 ◽  
Vol 47 (4) ◽  
pp. 597-599 ◽  
Author(s):  
I. V. Kulakov
Keyword(s):  
Biological Activity ◽  
Alkaloid Cytisine

ChemInform Abstract: Synthesis of N-Aminoglycosides Derived from Alkaloid Cytisine, Their Biological Activity and Crystal Structure of N-(β-D-Galactopyranosyl)cytisine.

ChemInform ◽  
2010 ◽  
Vol 41 (49) ◽  
pp. no-no
Author(s):  
I. V. Kulakov ◽  
O. A. Nurkenov ◽  
D. M. Turdybekov ◽  
A. S. Mahmutova ◽  
S. B. Ahmetova ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Biological Activity ◽  
Alkaloid Cytisine

Synthesis of n-aminoglycosides derived from alkaloid cytisine, their biological activity and crystal structure of N-(β-D-galactopyranosyl)cytisine

2010 ◽  
Vol 46 (2) ◽  
pp. 240-244 ◽  
Author(s):  
I. V. Kulakov ◽  
O. A. Nurkenov ◽  
D. M. Turdybekov ◽  
A. S. Mahmutova ◽  
S. B. Ahmetova ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Biological Activity ◽  
Alkaloid Cytisine

scholarly journals Synthesis, quantum-chemical calculations and virtual screening of the alkaloid cytisine derivatives

2021 ◽  
Vol 104 (4) ◽  
pp. 21-29
Author(s):  
Zh.S. Nurmaganbetov ◽  
◽  
G.K. Mukusheva ◽  
Ye.V. Minayeva ◽  
D.M. Turdybekov ◽  
...  
Keyword(s):  
Biological Activity ◽  
Virtual Screening ◽  
Quantum Chemical Calculations ◽  
Quantum Chemical ◽  
Reaction Centers ◽  
Frontier Molecular Orbitals ◽  
Chemical Calculation ◽  
Cytisine Derivatives ◽  
Alkaloid Cytisine ◽  
Potential Sources

The synthesis of some cytisine derivatives was carried out in the work. The article provides the data of quantum-chemical calculation and virtual screening of the alkaloid cytisine derivatives synthesized. At the same time, the reaction centers of the cytisine derivatives molecules were determined. In order to study the reactivity of the derivatives obtained (namely cinnamoylcytisine, lipoylcytisine, and cytisinylisoalantholactone) the quantum-chemical calculations were conducted to determine the energy and charge characteristics of the molecules. The results indicate a sufficient thermodynamic stability of the cinnamoylcytisine and lipoylcytisine molecules. The cytisinylisoalantholactone molecule is not stable according to the results of quantum chemical calculations. The data on the energy values of the frontier molecular orbitals show that, in general, all molecules exhibit electrophilic properties. A bioprediction was implemented using PASS (Prediction of Activity Spectra for Substances) as one of the most efficient and well-known computer program with the aim of detailed study and the probable establishment of the biological activity of the synthesized cytisine derivatives. Based on the results of virtual screening, promising types of alkaloid cytisine derivatives were identified, which are potential sources of original drugs

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Effects of Vincristine on Endothelial Microtubules in the Spinal Cord

1976 ◽  
Vol 34 ◽  
pp. 58-59
Author(s):  
John L. Beggs ◽  
John D. Waggener ◽  
Wanda Miller
Keyword(s):  
Spinal Cord ◽  
Biological Activity ◽  
Horseradish Peroxidase ◽  
Transport Mechanism ◽  
Vasogenic Edema ◽  
Vesicular Transport ◽  
Close Proximity

Microtubules (MT) are versatile organelles participating in a wide variety of biological activity. MT involvement in the movement and transport of cytoplasmic components has been well documented. In the course of our study on trauma-induced vasogenic edema in the spinal cord we have concluded that endothelial vesicles contribute to the edema process. Using horseradish peroxidase as a vascular tracer, labeled endothelial vesicles were present in all situations expected if a vesicular transport mechanism was in operation. Frequently,labeled vesicles coalesced to form channels that appeared to traverse the endothelium. The presence of MT in close proximity to labeled vesicles sugg ested that MT may play a role in vesicular activity.

Isothiazol-3(2 H )-ones, Part I: Synthesis, Reactions and Biological Activity

2002 ◽  
Vol 23 (1) ◽  
pp. 79-121 ◽  
Author(s):  
Kathleen Taubert ◽  
Susanne Kraus ◽  
Bärbel Schulze
Keyword(s):  
Biological Activity ◽  
Synthesis Reactions

Evaluation of biological activity of lignans extracted from tree knots

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
E Spilioti ◽  
B Holmbom ◽  
P Moutsatsou
Keyword(s):  
Biological Activity

Phytochemical analysis and biological activity of the flavonoids from the Mongolian medicinal plant Dianthus versicolor Fisch.

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
A Obmann ◽  
A Presser ◽  
C Kletter ◽  
T Thalhammer ◽  
S Glasl
Keyword(s):  
Biological Activity ◽  
Medicinal Plant ◽  
Phytochemical Analysis

Investigation of volatiles, lipoidal matter and biological activity of the aerial parts of Dichrostachys cinerea L.

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
AH Abou Zeid ◽  
MS Hifnawy ◽  
AA Sleem ◽  
RS Mohammed
Keyword(s):  
Biological Activity ◽  
Dichrostachys Cinerea ◽  
Aerial Parts

Taxonomy, occurrence, phytochemical evaluation and biological activity of selected basidiomycetes from Yemen

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
M Al-Fatimi ◽  
H Kreisel ◽  
U Lindequist
Keyword(s):  
Biological Activity
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