The Clinical Value of Serum Connective Tissue Growth Factor in the Assessment of Liver Fibrosis

2009 ◽  
Vol 55 (3) ◽  
pp. 767-774 ◽  
Author(s):  
Dai Zhang ◽  
Nian-Yue Wang ◽  
Cheng-Bao Yang ◽  
Guo-Xiang Fang ◽  
Wei Liu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Fibrosis ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Clinical Value

Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats

2006 ◽  
Vol 8 (7) ◽  
pp. 889-900 ◽  
Author(s):  
Guangming Li ◽  
Qing Xie ◽  
Yi Shi ◽  
Dingguo Li ◽  
Mingjun Zhang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Fibrosis ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth

Silymarin Decreases Connective Tissue Growth Factor to Improve Liver Fibrosis in Rats Treated with Carbon Tetrachloride

2012 ◽  
Vol 27 (7) ◽  
pp. 1023-1028 ◽  
Author(s):  
Jann‐Inn Tzeng ◽  
Mei‐Fen Chen ◽  
Hsien‐Hui Chung ◽  
Juei‐Tang Cheng
Keyword(s):  
Carbon Tetrachloride ◽  
Growth Factor ◽  
Liver Fibrosis ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth

scholarly journals Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes

Hepatology ◽  
2009 ◽  
Vol 50 (3) ◽  
pp. 939-947 ◽  
Author(s):  
ZhenYue Tong ◽  
Ruju Chen ◽  
Daniel S. Alt ◽  
Sherri Kemper ◽  
Bernard Perbal ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Fibrosis ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth

Hesperidin Prevents Liver Fibrosis in Rats by Decreasing the Expression of Nuclear Factor-κB, Transforming Growth Factor-� and Connective Tissue Growth Factor

Pharmacology ◽  
2014 ◽  
Vol 94 (1-2) ◽  
pp. 80-89 ◽  
Author(s):  
J. Eliuth Pérez-Vargas ◽  
Natanael Zarco ◽  
Mineko Shibayama ◽  
José Segovia ◽  
Víctor Tsutsumi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Fibrosis ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Transforming Growth Factor ◽  
Nuclear Factor Κb ◽  
Tissue Growth ◽  
Nuclear Factor

scholarly journals Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connective Tissue Growth Factor

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 558 ◽  
Author(s):  
Hye-Young Seo ◽  
So-Hee Lee ◽  
Ji-Ha Lee ◽  
Yu Na Kang ◽  
Jae Seok Hwang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Fibrosis ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Mouse Liver ◽  
Type I Collagen ◽  
Transforming Growth Factor ◽  
Tissue Growth ◽  
Type I ◽  
Induced Expression

The SRC kinase family comprises non-receptor tyrosine kinases that are ubiquitously expressed in all cell types. Although Src is reportedly activated in pulmonary and renal fibrosis, little is known regarding its role in liver fibrosis. This study investigated whether the inhibition of Src protects against liver fibrosis. The expression of Src was upregulated in thioacetamide (TAA)-induced fibrotic mouse liver and cirrhosis of patients, and phospho-Src was upregulated during activation of hepatic stellate cells (HSC). In addition, Src inhibition reduced the expression of α-smooth muscle actin (αSMA) in primary HSCs and suppressed transforming growth factor β (TGF-β)-induced expression of connective tissue growth factor (CTGF) in hepatocytes. Src inhibitor Saracatinib also attenuated TAA-induced expression of type I collagen, αSMA, and CTGF in mouse liver tissues. The antifibrotic effect of Src inhibitors was associated with the downregulation of Smad3, but not of signal transducer and activator of transcription 3 (STAT3). In addition, Src inhibition increased autophagy flux and protected against liver fibrosis. These results suggest that Src plays an important role in liver fibrosis and that Src inhibitors could be treat liver fibrosis.

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