Serological Risk Index Based on Alpha-Fetoprotein and C-Reactive Protein to Indicate Futile Liver Transplantation Among Patients with Advanced Hepatocellular Carcinoma

2018 ◽  
Vol 64 (1) ◽  
pp. 269-280
Author(s):  
Arno Kornberg ◽  
Martina Schernhammer ◽  
Jennifer Kornberg ◽  
Helmut Friess ◽  
Katharina Thrum
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Risk Index ◽  
Alpha Fetoprotein ◽  
Advanced Hepatocellular Carcinoma ◽  
C Reactive Protein ◽  
Reactive Protein

Liver transplantation for hepatocellular carcinoma with portal vein tumor thrombosis

2021 ◽  
Vol 21 (2) ◽  
pp. 105-112
Author(s):  
Sang Jin Kim ◽  
Jong Man Kim
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Radiation Therapy ◽  
Portal Vein ◽  
Alpha Fetoprotein ◽  
Advanced Hepatocellular Carcinoma ◽  
Portal Vein Tumor Thrombosis ◽  
Donor Liver Transplantation ◽  
Tumor Thrombosis ◽  
Locoregional Therapies

Traditionally, liver transplantation for hepatocellular carcinoma with portal vein tumor thrombosis is not recommended. However, with recent developments in locoregional therapies for hepatocellular carcinoma, more aggressive treatments have been attempted for advanced hepatocellular carcinoma. Recently, various studies on locoregional therapies for downstaging followed by living donor liver transplantation reported inspiring overall survival and recurrence-free survival of patients. These downstaging procedures included three-dimensional conformal radiation therapy, trans-arterial chemoembolization, stereotactic body radiation therapy, trans-arterial radioembolization, hepatic arterial infusion chemotherapy and combinations of these therapies. Selection of the optimal downstaging protocol should depend on tumor location, biology and background liver status. The risk factors affecting outcome include pre-downstaging alpha-fetoprotein values, delta alpha-fetoprotein values, disappearance of portal vein tumor thrombosis on imaging and meeting the Milan criteria or not after downstaging. For hepatocellular carcinoma with portal vein tumor thrombosis, downstaging procedure with liver transplantation in mind would be helpful. If the reaction of the downstaged tumor is good, liver transplantation may be performed.

scholarly journals Novel Pretreatment Scoring Incorporating C-reactive Protein to Predict Overall Survival in Advanced Hepatocellular Carcinoma with Sorafenib Treatment

Liver Cancer ◽  
2016 ◽  
Vol 5 (4) ◽  
pp. 257-268 ◽  
Author(s):  
Hiroyuki Nakanishi ◽  
Masayuki Kurosaki ◽  
Kaoru Tsuchiya ◽  
Yutaka Yasui ◽  
Mayu Higuchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Overall Survival ◽  
Advanced Hepatocellular Carcinoma ◽  
C Reactive Protein ◽  
Sorafenib Treatment ◽  
Reactive Protein

C-reactive protein as a biomarker to predict outcomes after liver transplantation for hepatocellular carcinoma.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 4086-4086
Author(s):  
H. J. An ◽  
J. W. Jang ◽  
M. A. Lee ◽  
S. H. Bae ◽  
J. Y. Choi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
C Reactive Protein ◽  
Reactive Protein

Postoperative peak serum C-reactive protein is a predictor of outcome following liver transplantation for hepatocellular carcinoma

Biomarkers ◽  
2015 ◽  
Vol 21 (2) ◽  
pp. 152-159 ◽  
Author(s):  
Arno Kornberg ◽  
Ulrike Witt ◽  
Jennifer Kornberg ◽  
Katharina Müller ◽  
Helmut Friess ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Peak Serum ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals C-reactive protein is an independent predictor for hepatocellular carcinoma recurrence after liver transplantation

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0216677 ◽  
Author(s):  
Tobias Meischl ◽  
Susanne Rasoul-Rockenschaub ◽  
Georg Györi ◽  
Wolfgang Sieghart ◽  
Thomas Reiberger ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Independent Predictor ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hepatocellular Carcinoma Recurrence

scholarly journals Serum C‐reactive protein is a useful biomarker for predicting outcomes after liver transplantation in patients with hepatocellular carcinoma

2012 ◽  
Vol 18 (12) ◽  
pp. 1406-1414 ◽  
Author(s):  
Ho Jung An ◽  
Jeong Won Jang ◽  
Si Hyun Bae ◽  
Jong Young Choi ◽  
Seung Kew Yoon ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
C Reactive Protein ◽  
Reactive Protein
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